ID   IFNA7_HUMAN             Reviewed;         189 AA.
AC   P01567; Q14607; Q5VV14;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   13-FEB-2019, entry version 168.
DE   RecName: Full=Interferon alpha-7;
DE            Short=IFN-alpha-7;
DE   AltName: Full=Interferon alpha-J;
DE            Short=LeIF J;
DE   AltName: Full=Interferon alpha-J1;
DE            Short=IFN-alpha-J1;
DE   Flags: Precursor;
GN   Name=IFNA7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6181262; DOI=10.1016/0022-2836(82)90261-3;
RA   Ullrich A., Gray A., Goeddel D.V., Dull T.J.;
RT   "Nucleotide sequence of a portion of human chromosome 9 containing a
RT   leukocyte interferon gene cluster.";
RL   J. Mol. Biol. 156:467-486(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2;
RA   Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R.,
RA   Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J.,
RA   Todokoro K., Waelchli M., Nagata S., Weissmann C.;
RT   "Structural relationship of human interferon alpha genes and
RT   pseudogenes.";
RL   J. Mol. Biol. 185:227-260(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2995168;
RA   Cohen S., Velan B., Grosfeld H., Shalita Z., Leitner M.,
RA   Shafferman A.;
RT   "Cloning, expression and biological activity of a new variant of human
RT   interferon alpha identified in virus induced lymphoblastoid cells.";
RL   Dev. Biol. Stand. 60:111-122(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 24-57.
RX   PubMed=9425112; DOI=10.1042/bj3290295;
RA   Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT   "Identification of nine interferon-alpha subtypes produced by Sendai
RT   virus-induced human peripheral blood leucocytes.";
RL   Biochem. J. 329:295-302(1998).
RN   [8]
RP   ABSENCE OF POLYMORPHISM.
RX   PubMed=8910771; DOI=10.1089/jir.1996.16.853;
RA   Hussain M., Gill D.S., Liao M.-J.;
RT   "Identification of interferon-alpha 7, -alpha 14, and -alpha 21
RT   variants in the genome of a large human population.";
RL   J. Interferon Cytokine Res. 16:853-859(1996).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral
CC       activities. Interferon stimulates the production of two enzymes: a
CC       protein kinase and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC       {ECO:0000305}.
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DR   EMBL; V00531; CAA23792.1; -; Genomic_DNA.
DR   EMBL; X02960; CAA26706.1; -; Genomic_DNA.
DR   EMBL; M34913; AAA36039.1; -; mRNA.
DR   EMBL; AL512606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58620.1; -; Genomic_DNA.
DR   EMBL; BC074991; AAH74991.1; -; mRNA.
DR   EMBL; BC074992; AAH74992.1; -; mRNA.
DR   EMBL; BC113994; AAI13995.1; -; mRNA.
DR   EMBL; BC114000; AAI14001.1; -; mRNA.
DR   CCDS; CCDS34995.1; -.
DR   PIR; A01831; IVHUA0.
DR   PIR; F25843; F25843.
DR   PIR; I53102; I53102.
DR   RefSeq; NP_066401.2; NM_021057.2.
DR   UniGene; Hs.282274; -.
DR   ProteinModelPortal; P01567; -.
DR   SMR; P01567; -.
DR   BioGrid; 109667; 7.
DR   STRING; 9606.ENSP00000239347; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   iPTMnet; P01567; -.
DR   PhosphoSitePlus; P01567; -.
DR   BioMuta; IFNA7; -.
DR   DMDM; 124442; -.
DR   PaxDb; P01567; -.
DR   PeptideAtlas; P01567; -.
DR   PRIDE; P01567; -.
DR   ProteomicsDB; 51383; -.
DR   Ensembl; ENST00000239347; ENSP00000239347; ENSG00000214042.
DR   GeneID; 3444; -.
DR   KEGG; hsa:3444; -.
DR   UCSC; uc003zop.1; human.
DR   CTD; 3444; -.
DR   DisGeNET; 3444; -.
DR   EuPathDB; HostDB:ENSG00000214042.1; -.
DR   GeneCards; IFNA7; -.
DR   HGNC; HGNC:5428; IFNA7.
DR   HPA; HPA047557; -.
DR   MIM; 147567; gene.
DR   neXtProt; NX_P01567; -.
DR   OpenTargets; ENSG00000214042; -.
DR   PharmGKB; PA29667; -.
DR   eggNOG; ENOG410J735; Eukaryota.
DR   eggNOG; ENOG410ZH91; LUCA.
DR   GeneTree; ENSGT00940000153163; -.
DR   HOGENOM; HOG000230500; -.
DR   HOVERGEN; HBG052086; -.
DR   InParanoid; P01567; -.
DR   KO; K05414; -.
DR   OMA; LCAWEVI; -.
DR   OrthoDB; 1358010at2759; -.
DR   PhylomeDB; P01567; -.
DR   TreeFam; TF336177; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   GeneWiki; IFNA7; -.
DR   GenomeRNAi; 3444; -.
DR   PRO; PR:P01567; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000214042; Expressed in 2 organ(s), highest expression level in blood.
DR   Genevisible; P01567; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0009615; P:response to virus; TAS:ProtInc.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome.
DR   CDD; cd00095; IFab; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Complete proteome; Cytokine;
KW   Direct protein sequencing; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000269|PubMed:9425112}.
FT   CHAIN        24    189       Interferon alpha-7.
FT                                /FTId=PRO_0000016364.
FT   DISULFID     24    122       {ECO:0000250}.
FT   DISULFID     52    162       {ECO:0000250}.
FT   CONFLICT     10     10       V -> A (in Ref. 3; AAA36039).
FT                                {ECO:0000305}.
FT   CONFLICT    155    155       M -> T (in Ref. 3; AAA36039).
FT                                {ECO:0000305}.
SQ   SEQUENCE   189 AA;  22107 MW;  9DF6F5C81E339A42 CRC64;
     MARSFSLLMV VLVLSYKSIC SLGCDLPQTH SLRNRRALIL LAQMGRISPF SCLKDRHEFR
     FPEEEFDGHQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE
     ACVIQEVGVE ETPLMNEDFI LAVRKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSFSFSTN
     LKKGLRRKD
//