ID   IFN10_HUMAN             Reviewed;         189 AA.
AC   P01566; Q5VV13;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   13-FEB-2019, entry version 168.
DE   RecName: Full=Interferon alpha-10;
DE            Short=IFN-alpha-10;
DE   AltName: Full=Interferon alpha-6L;
DE   AltName: Full=Interferon alpha-C;
DE            Short=LeIF C;
DE   Flags: Precursor;
GN   Name=IFNA10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6163083; DOI=10.1038/290020a0;
RA   Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M.,
RA   McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.;
RT   "The structure of eight distinct cloned human leukocyte interferon
RT   cDNAs.";
RL   Nature 290:20-26(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2526839; DOI=10.1089/jir.1989.9.407;
RA   Bartholomew C., Windass J.D.;
RT   "Identification of a functional allele of a human interferon-alpha
RT   gene previously characterized as a pseudogene.";
RL   J. Interferon Res. 9:407-417(1989).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 24-53.
RX   PubMed=9425112; DOI=10.1042/bj3290295;
RA   Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT   "Identification of nine interferon-alpha subtypes produced by Sendai
RT   virus-induced human peripheral blood leucocytes.";
RL   Biochem. J. 329:295-302(1998).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral
CC       activities. Interferon stimulates the production of two enzymes: a
CC       protein kinase and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC       {ECO:0000305}.
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DR   EMBL; V00551; CAA23812.1; -; mRNA.
DR   EMBL; AL512606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58619.1; -; Genomic_DNA.
DR   EMBL; BC069409; AAH69409.1; -; mRNA.
DR   EMBL; BC103972; AAI03973.1; -; mRNA.
DR   EMBL; BC103973; AAI03974.1; -; mRNA.
DR   CCDS; CCDS6499.1; -.
DR   PIR; A60937; IVHUA5.
DR   RefSeq; NP_002162.1; NM_002171.2.
DR   UniGene; Hs.282275; -.
DR   ProteinModelPortal; P01566; -.
DR   SMR; P01566; -.
DR   BioGrid; 109669; 3.
DR   STRING; 9606.ENSP00000369566; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   BioMuta; IFNA10; -.
DR   DMDM; 124453; -.
DR   jPOST; P01566; -.
DR   PaxDb; P01566; -.
DR   PeptideAtlas; P01566; -.
DR   PRIDE; P01566; -.
DR   ProteomicsDB; 51382; -.
DR   Ensembl; ENST00000357374; ENSP00000369566; ENSG00000186803.
DR   GeneID; 3446; -.
DR   KEGG; hsa:3446; -.
DR   UCSC; uc003zoq.1; human.
DR   CTD; 3446; -.
DR   DisGeNET; 3446; -.
DR   EuPathDB; HostDB:ENSG00000186803.3; -.
DR   GeneCards; IFNA10; -.
DR   HGNC; HGNC:5418; IFNA10.
DR   HPA; HPA047557; -.
DR   MIM; 147577; gene.
DR   neXtProt; NX_P01566; -.
DR   OpenTargets; ENSG00000186803; -.
DR   PharmGKB; PA29657; -.
DR   eggNOG; ENOG410J735; Eukaryota.
DR   eggNOG; ENOG410ZH91; LUCA.
DR   GeneTree; ENSGT00940000153163; -.
DR   HOGENOM; HOG000230500; -.
DR   HOVERGEN; HBG052086; -.
DR   InParanoid; P01566; -.
DR   KO; K05414; -.
DR   OMA; RKYSPCA; -.
DR   OrthoDB; 1358010at2759; -.
DR   PhylomeDB; P01566; -.
DR   TreeFam; TF336177; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   SIGNOR; P01566; -.
DR   GeneWiki; IFNA10; -.
DR   GenomeRNAi; 3446; -.
DR   PRO; PR:P01566; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000186803; Expressed in 1 organ(s), highest expression level in blood.
DR   Genevisible; P01566; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome.
DR   CDD; cd00095; IFab; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Complete proteome; Cytokine;
KW   Direct protein sequencing; Disulfide bond; Polymorphism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000269|PubMed:9425112}.
FT   CHAIN        24    189       Interferon alpha-10.
FT                                /FTId=PRO_0000016366.
FT   DISULFID     24    122       {ECO:0000250}.
FT   DISULFID     52    162       {ECO:0000250}.
FT   VARIANT      42     42       G -> A (in dbSNP:rs2230853).
FT                                /FTId=VAR_029227.
SQ   SEQUENCE   189 AA;  21835 MW;  CEC680996FDA706B CRC64;
     MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LGQMGRISPF SCLKDRHDFR
     IPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE
     ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI TLYLIERKYS PCAWEVVRAE IMRSLSFSTN
     LQKRLRRKD
//