ID IFNA1_HUMAN Reviewed; 189 AA. AC P01562; D4Q9M8; Q14605; Q2M1L8; Q52LB8; Q5VYQ2; Q7M4Q1; Q8WZ68; AC Q9UMJ3; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 13-FEB-2019, entry version 189. DE RecName: Full=Interferon alpha-1/13; DE Short=IFN-alpha-1/13; DE AltName: Full=Interferon alpha-D; DE Short=LeIF D; DE Flags: Precursor; GN Name=IFNA1; GN and GN Name=IFNA13; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6157600; DOI=10.1016/0378-1119(80)90137-7; RA Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., RA Weissmann C.; RT "The nucleotide sequence of a cloned human leukocyte interferon RT cDNA."; RL Gene 10:1-10(1980). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6157095; DOI=10.1038/285547a0; RA Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., RA Weissmann C.; RT "Human leukocyte and fibroblast interferons are structurally RT related."; RL Nature 285:547-549(1980). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6163083; DOI=10.1038/290020a0; RA Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., RA McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.; RT "The structure of eight distinct cloned human leukocyte interferon RT cDNAs."; RL Nature 290:20-26(1981). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6479148; RA Todokoro K., Kioussis D., Weissmann C.; RT "Two non-allelic human interferon alpha genes with identical coding RT regions."; RL EMBO J. 3:1809-1812(1984). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2; RA Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., RA Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., RA Todokoro K., Waelchli M., Nagata S., Weissmann C.; RT "Structural relationship of human interferon alpha genes and RT pseudogenes."; RL J. Mol. Biol. 185:227-260(1985). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2985969; DOI=10.1128/MCB.5.4.768; RA Capon D.J., Shepard H.M., Goeddel D.V.; RT "Two distinct families of human and bovine interferon-alpha genes are RT coordinately expressed and encode functional polypeptides."; RL Mol. Cell. Biol. 5:768-779(1985). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=20857263; DOI=10.1007/s00795-010-0492-5; RA Kimura T., Hashimoto I., Nishizawa M., Ito S., Yamada H.; RT "Novel cis-active structures in the coding region mediate CRM1- RT dependent nuclear export of IFN-alpha 1 mRNA."; RL Med. Mol. Morphol. 43:145-157(2010). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-10. RA Rostoks N.; RL Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-10; VAL-137 AND RP GLY-163. RG NIEHS SNPs program; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-10. RC TISSUE=Cerebellum; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. RX PubMed=6310510; DOI=10.1093/nar/11.16.5661; RA Weber H., Weissmann C.; RT "Formation of genes coding for hybrid proteins by recombination RT between related, cloned genes in E. coli."; RL Nucleic Acids Res. 11:5661-5669(1983). RN [14] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. RC TISSUE=Leukocyte; RA Chen H.H., Yu X.B.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [15] RP PROTEIN SEQUENCE OF 24-59, AND FUNCTION. RX PubMed=1634550; RA Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., RA Nguyen N.Y., Hu R.-Q.; RT "Purification and characterization of multiple components of human RT lymphoblastoid interferon-alpha."; RL J. Biol. Chem. 267:15210-15216(1992). RN [16] RP PROTEIN SEQUENCE OF 24-58. RX PubMed=9425112; DOI=10.1042/bj3290295; RA Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.; RT "Identification of nine interferon-alpha subtypes produced by Sendai RT virus-induced human peripheral blood leucocytes."; RL Biochem. J. 329:295-302(1998). RN [17] RP POLYMORPHISM. RX PubMed=11032395; DOI=10.1089/10799900050151021; RA Hussain M., Ni D., Gill D., Liao M.-J.; RT "IFN-alpha-1a gene is the major variant in the North American RT population."; RL J. Interferon Cytokine Res. 20:763-768(2000). RN [18] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 24-189 IN COMPLEX WITH RP ANTIBODY, AND DISULFIDE BOND. RX PubMed=22307521; DOI=10.1007/s00109-012-0866-3; RA Ouyang S., Gong B., Li J.Z., Zhao L.X., Wu W., Zhang F.S., Sun L., RA Wang S.J., Pan M., Li C., Liang W., Shaw N., Zheng J., Zhao G.P., RA Wang Y., Liu Z.J., Liang M.; RT "Structural insights into a human anti-IFN antibody exerting RT therapeutic potential for systemic lupus erythematosus."; RL J. Mol. Med. 90:837-846(2012). CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral CC activities. Interferon stimulates the production of two enzymes: a CC protein kinase and an oligoadenylate synthetase. CC {ECO:0000269|PubMed:1634550}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- POLYMORPHISM: Two forms exist; alpha-1a (shown here) and alpha-1b CC (PubMed:11032395). {ECO:0000269|PubMed:11032395}. CC -!- MISCELLANEOUS: Interferons alpha-1 and alpha-13 have identical CC protein sequences. CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/ifna1/"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; V00537; CAA23798.1; -; mRNA. DR EMBL; J00210; AAB59403.1; -; Genomic_DNA. DR EMBL; V00538; CAA23799.1; -; mRNA. DR EMBL; X00803; CAA25381.1; -; Genomic_DNA. DR EMBL; X75934; CAA53538.1; -; Genomic_DNA. DR EMBL; AB445100; BAI99735.1; -; Genomic_DNA. DR EMBL; DQ185447; ABA03167.1; -; Genomic_DNA. DR EMBL; AL353732; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471071; EAW58609.1; -; Genomic_DNA. DR EMBL; BC069427; AAH69427.1; -; mRNA. DR EMBL; BC074928; AAH74928.1; -; mRNA. DR EMBL; BC074929; AAH74929.1; -; mRNA. DR EMBL; BC093988; AAH93988.1; -; mRNA. DR EMBL; BC112002; AAI12003.1; -; mRNA. DR EMBL; BC112300; AAI12301.1; -; mRNA. DR EMBL; BC112302; AAI12303.1; -; mRNA. DR EMBL; M29884; AAA52714.1; -; Genomic_DNA. DR EMBL; AF439447; AAL35223.1; -; Genomic_DNA. DR CCDS; CCDS6508.1; -. DR PIR; C23285; IVHUA1. DR PIR; F42753; F42753. DR PIR; H42753; H42753. DR RefSeq; NP_008831.3; NM_006900.3. DR RefSeq; NP_076918.1; NM_024013.2. DR UniGene; Hs.37026; -. DR UniGene; Hs.533471; -. DR PDB; 3UX9; X-ray; 2.80 A; A/C=24-189. DR PDBsum; 3UX9; -. DR ProteinModelPortal; P01562; -. DR SMR; P01562; -. DR BioGrid; 109662; 8. DR BioGrid; 109670; 7. DR DIP; DIP-6020N; -. DR IntAct; P01562; 2. DR MINT; P01562; -. DR STRING; 9606.ENSP00000276927; -. DR ChEMBL; CHEMBL3713007; -. DR iPTMnet; P01562; -. DR PhosphoSitePlus; P01562; -. DR BioMuta; IFNA1; -. DR DMDM; 124455; -. DR MaxQB; P01562; -. DR PaxDb; P01562; -. DR PeptideAtlas; P01562; -. DR PRIDE; P01562; -. DR ProteomicsDB; 51380; -. DR DNASU; 3439; -. DR DNASU; 3447; -. DR Ensembl; ENST00000276927; ENSP00000276927; ENSG00000197919. DR Ensembl; ENST00000449498; ENSP00000394494; ENSG00000233816. DR GeneID; 3439; -. DR GeneID; 3447; -. DR KEGG; hsa:3439; -. DR KEGG; hsa:3447; -. DR UCSC; uc003zpd.2; human. DR CTD; 3439; -. DR CTD; 3447; -. DR DisGeNET; 3439; -. DR DisGeNET; 3447; -. DR EuPathDB; HostDB:ENSG00000197919.4; -. DR EuPathDB; HostDB:ENSG00000233816.3; -. DR GeneCards; IFNA1; -. DR GeneCards; IFNA13; -. DR HGNC; HGNC:5417; IFNA1. DR HGNC; HGNC:5419; IFNA13. DR HPA; HPA047557; -. DR MIM; 147578; gene. DR MIM; 147660; gene. DR neXtProt; NX_P01562; -. DR OpenTargets; ENSG00000197919; -. DR PharmGKB; PA29658; -. DR eggNOG; ENOG410IR8X; Eukaryota. DR eggNOG; ENOG4110Q1A; LUCA. DR GeneTree; ENSGT00940000153163; -. DR HOVERGEN; HBG052086; -. DR InParanoid; P01562; -. DR KO; K05414; -. DR OMA; DSYAAWD; -. DR OrthoDB; 1358010at2759; -. DR PhylomeDB; P01562; -. DR TreeFam; TF336177; -. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-912694; Regulation of IFNA signaling. DR Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation. DR Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production. DR SignaLink; P01562; -. DR SIGNOR; P01562; -. DR GeneWiki; IFNA13; -. DR GeneWiki; Interferon,_alpha_1; -. DR PRO; PR:P01562; -. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000197919; Expressed in 18 organ(s), highest expression level in hypothalamus. DR ExpressionAtlas; P01562; baseline and differential. DR Genevisible; P01562; HS. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central. DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central. DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central. DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central. DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central. DR GO; GO:0007596; P:blood coagulation; TAS:Reactome. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW. DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central. DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central. DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central. DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central. DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central. DR GO; GO:0060337; P:type I interferon signaling pathway; TAS:Reactome. DR CDD; cd00095; IFab; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR000471; Interferon_alpha/beta/delta. DR PANTHER; PTHR11691; PTHR11691; 1. DR Pfam; PF00143; Interferon; 1. DR PRINTS; PR00266; INTERFERONAB. DR SMART; SM00076; IFabd; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00252; INTERFERON_A_B_D; 1. PE 1: Evidence at protein level; KW 3D-structure; Antiviral defense; Complete proteome; Cytokine; KW Direct protein sequencing; Disulfide bond; Polymorphism; KW Reference proteome; Secreted; Signal. FT SIGNAL 1 23 {ECO:0000269|PubMed:1634550, FT ECO:0000269|PubMed:9425112}. FT CHAIN 24 189 Interferon alpha-1/13. FT /FTId=PRO_0000016359. FT DISULFID 24 122 {ECO:0000250}. FT DISULFID 52 162 {ECO:0000269|PubMed:22307521}. FT VARIANT 10 10 V -> A (in dbSNP:rs1758567). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|Ref.8, ECO:0000269|Ref.9}. FT /FTId=VAR_024508. FT VARIANT 137 137 A -> V (in alpha-1B; dbSNP:rs2230050). FT {ECO:0000269|Ref.9}. FT /FTId=VAR_013000. FT VARIANT 163 163 A -> G (in dbSNP:rs28383794). FT {ECO:0000269|Ref.9}. FT /FTId=VAR_025173. FT CONFLICT 116 116 L -> P (in Ref. 14; AAL35223). FT {ECO:0000305}. FT CONFLICT 172 172 M -> V (in Ref. 14; AAL35223). FT {ECO:0000305}. FT HELIX 35 43 {ECO:0000244|PDB:3UX9}. FT HELIX 49 51 {ECO:0000244|PDB:3UX9}. FT TURN 53 55 {ECO:0000244|PDB:3UX9}. FT HELIX 63 66 {ECO:0000244|PDB:3UX9}. FT HELIX 77 91 {ECO:0000244|PDB:3UX9}. FT HELIX 94 99 {ECO:0000244|PDB:3UX9}. FT HELIX 102 122 {ECO:0000244|PDB:3UX9}. FT HELIX 137 156 {ECO:0000244|PDB:3UX9}. FT TURN 157 159 {ECO:0000244|PDB:3UX9}. FT HELIX 161 178 {ECO:0000244|PDB:3UX9}. SQ SEQUENCE 189 AA; 21725 MW; F32F9CB969606B69 CRC64; MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE //