ID   ANF_HUMAN               Reviewed;         153 AA.
AC   P01160; Q13766; Q5JZE1;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   13-FEB-2019, entry version 199.
DE   RecName: Full=Natriuretic peptides A;
DE   AltName: Full=CDD-ANF;
DE   AltName: Full=Cardiodilatin;
DE            Short=CDD;
DE   AltName: Full=Cardiodilatin-related peptide;
DE            Short=CDP;
DE   AltName: Full=Prepronatriodilatin;
DE   Contains:
DE     RecName: Full=Atrial natriuretic factor;
DE              Short=ANF;
DE     AltName: Full=Atrial natriuretic peptide;
DE              Short=ANP;
DE   Flags: Precursor;
GN   Name=NPPA; Synonyms=ANP, PND;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
RX   PubMed=6203042; DOI=10.1038/309724a0;
RA   Oikawa S., Imai M., Ueno A., Tanaka S., Noguchi T., Nakazato H.,
RA   Kangawa K., Fukuda A., Matsuo H.;
RT   "Cloning and sequence analysis of cDNA encoding a precursor for human
RT   atrial natriuretic polypeptide.";
RL   Nature 309:724-726(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
RX   PubMed=6547996; DOI=10.1038/310699a0;
RA   Nakayama K., Ohkubo H., Hirose T., Inayama S., Nakanishi S.;
RT   "mRNA sequence for human cardiodilatin-atrial natriuretic factor
RT   precursor and regulation of precursor mRNA in rat atria.";
RL   Nature 310:699-701(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
RX   PubMed=6095118; DOI=10.1038/312654a0;
RA   Nemer M., Chamberland M., Sirois D., Argentin S., Drouin J.,
RA   Dixon R.A.F., Zivin R.A., Condra J.H.;
RT   "Gene structure of human cardiac hormone precursor,
RT   pronatriodilatin.";
RL   Nature 312:654-656(1984).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
RX   PubMed=6095119; DOI=10.1038/312656a0;
RA   Greenberg B.D., Bencen G.H., Seilhamer J.J., Lewicki J.A.,
RA   Fiddes J.C.;
RT   "Nucleotide sequence of the gene encoding human atrial natriuretic
RT   factor precursor.";
RL   Nature 312:656-658(1984).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
RX   PubMed=6542248; DOI=10.1126/science.6542248;
RA   Seidman C.E., Bloch K.D., Klein K.A., Smith J.A., Seidman J.G.;
RT   "Nucleotide sequences of the human and mouse atrial natriuretic factor
RT   genes.";
RL   Science 226:1206-1209(1984).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
RX   PubMed=3158606;
RA   Seidman C.E., Bloch K.D., Zisfein J., Smit J., Haber E., Homcy C.,
RA   Duby A.D., Choi E., Graham R.M., Seidman J.G.;
RT   "Molecular studies of the atrial natriuretic factor gene.";
RL   Hypertension 7:I31-I34(1985).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
RG   NHLBI resequencing and genotyping service (RS&G);
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE 2).
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE 1).
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
RX   PubMed=6097248; DOI=10.1016/0006-291X(84)90609-0;
RA   Maki M., Parmentier M., Inagami T.;
RT   "Cloning of genomic DNA for human atrial natriuretic factor.";
RL   Biochem. Biophys. Res. Commun. 125:797-802(1984).
RN   [11]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 118-153 (ALLELE 1).
RX   PubMed=6238331; DOI=10.1073/pnas.81.20.6325;
RA   Zivin R.A., Condra J.H., Dixon R.A.F., Seidah N.G., Chretien M.,
RA   Nemer M., Chamberland M., Drouin J.;
RT   "Molecular cloning and characterization of DNA sequences encoding rat
RT   and human atrial natriuretic factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:6325-6329(1984).
RN   [12]
RP   PROTEIN SEQUENCE OF 124-151.
RX   PubMed=6230082; DOI=10.1016/0006-291X(84)91077-5;
RA   Kangawa K., Matsuo H.;
RT   "Purification and complete amino acid sequence of alpha-human atrial
RT   natriuretic polypeptide (alpha-hANP).";
RL   Biochem. Biophys. Res. Commun. 118:131-139(1984).
RN   [13]
RP   PROTEIN SEQUENCE OF 124-151.
RX   PubMed=1826098; DOI=10.1111/j.1432-1033.1991.tb15815.x;
RA   Vanneste Y., Michel A., Deschodt-Lanckman M.;
RT   "Hydrolysis of intact and Cys-Phe-cleaved human atrial natriuretic
RT   peptide in vitro by human tissue kallikrein.";
RL   Eur. J. Biochem. 196:281-286(1991).
RN   [14]
RP   PROTEOLYTIC PROCESSING BY MME, AND CLEAVAGE SITE.
RX   PubMed=2972276; DOI=10.1042/bj2540531;
RA   Vanneste Y., Michel A., Dimaline R., Najdovski T.,
RA   Deschodt-Lanckman M.;
RT   "Hydrolysis of alpha-human atrial natriuretic peptide in vitro by
RT   human kidney membranes and purified endopeptidase-24.11. Evidence for
RT   a novel cleavage site.";
RL   Biochem. J. 254:531-537(1988).
RN   [15]
RP   RECEPTOR-BINDING.
RX   PubMed=1660465;
RA   Bennett B.D., Bennett G.L., Vitangcol R.V., Jewett J.R., Burnier J.,
RA   Henzel W., Lowe D.G.;
RT   "Extracellular domain-IgG fusion proteins for three human natriuretic
RT   peptide receptors. Hormone pharmacology and application to solid phase
RT   screening of synthetic peptide antisera.";
RL   J. Biol. Chem. 266:23060-23067(1991).
RN   [16]
RP   FUNCTION.
RX   PubMed=1672777; DOI=10.1126/science.1672777;
RA   Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K.,
RA   Matsuo H., Goeddel D.V.;
RT   "Selective activation of the B natriuretic peptide receptor by C-type
RT   natriuretic peptide (CNP).";
RL   Science 252:120-123(1991).
RN   [17]
RP   PROTEOLYTIC PROCESSING, AND MUTAGENESIS OF ARG-123.
RX   PubMed=10880574; DOI=10.1073/pnas.150149097;
RA   Yan W., Wu F., Morser J., Wu Q.;
RT   "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial
RT   natriuretic peptide-converting enzyme.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000).
RN   [18]
RP   PROTEOLYTIC PROCESSING.
RX   PubMed=14559895; DOI=10.1074/jbc.M309991200;
RA   Knappe S., Wu F., Masikat M.R., Morser J., Wu Q.;
RT   "Functional analysis of the transmembrane domain and activation
RT   cleavage of human corin: design and characterization of a soluble
RT   corin.";
RL   J. Biol. Chem. 278:52363-52370(2003).
RN   [19]
RP   STRUCTURE BY NMR OF 124-151 MUTANT SELECTIVE FOR NPR-C RECEPTOR.
RX   PubMed=8043577; DOI=10.1021/bi00196a006;
RA   Fairbrother W.J., McDowell R.S., Cunningham B.C.;
RT   "Solution conformation of an atrial natriuretic peptide variant
RT   selective for the type A receptor.";
RL   Biochemistry 33:8897-8904(1994).
RN   [20]
RP   X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 129-149 IN COMPLEX WITH
RP   NPR3, AND DISULFIDE BOND.
RX   PubMed=16870210; DOI=10.1016/j.jmb.2006.06.060;
RA   He X.-L., Dukkipati A., Garcia K.C.;
RT   "Structural determinants of natriuretic peptide receptor specificity
RT   and degeneracy.";
RL   J. Mol. Biol. 361:698-714(2006).
RN   [21]
RP   INVOLVEMENT IN ATFB6.
RX   PubMed=18614783; DOI=10.1056/NEJMoa0706300;
RA   Hodgson-Zingman D.M., Karst M.L., Zingman L.V., Heublein D.M.,
RA   Darbar D., Herron K.J., Ballew J.D., de Andrade M., Burnett J.C. Jr.,
RA   Olson T.M.;
RT   "Atrial natriuretic peptide frameshift mutation in familial atrial
RT   fibrillation.";
RL   N. Engl. J. Med. 359:158-165(2008).
RN   [22]
RP   INVOLVEMENT IN ATRST2, AND VARIANT ATRST2 GLN-150.
RX   PubMed=23275345; DOI=10.1161/CIRCGENETICS.112.963520;
RA   Disertori M., Quintarelli S., Grasso M., Pilotto A., Narula N.,
RA   Favalli V., Canclini C., Diegoli M., Mazzola S., Marini M.,
RA   Del Greco M., Bonmassari R., Mase M., Ravelli F., Specchia C.,
RA   Arbustini E.;
RT   "Autosomal recessive atrial dilated cardiomyopathy with standstill
RT   evolution associated with mutation of natriuretic peptide precursor
RT   A.";
RL   Circ. Cardiovasc. Genet. 6:27-36(2013).
CC   -!- FUNCTION: Hormone playing a key role in cardiovascular homeostasis
CC       through regulation of natriuresis, diuresis, and vasodilation.
CC       Also plays a role in female pregnancy by promoting trophoblast
CC       invasion and spiral artery remodeling in uterus. Specifically
CC       binds and stimulates the cGMP production of the NPR1 receptor.
CC       Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}.
CC   -!- INTERACTION:
CC       P43365:MAGEA12; NbExp=5; IntAct=EBI-953859, EBI-749530;
CC       Q9UMX0:UBQLN1; NbExp=3; IntAct=EBI-953859, EBI-741480;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Cleaved by CORIN upon secretion to produce the functional
CC       hormone. {ECO:0000269|PubMed:10880574,
CC       ECO:0000269|PubMed:14559895}.
CC   -!- PTM: Atrial natriuretic factor: Cleaved by MME. The cleavage
CC       initiates degradation of the factor and thereby regulate its
CC       activity. {ECO:0000269|PubMed:2972276}.
CC   -!- POLYMORPHISM: There are two different prepronatriodilatin alleles.
CC       One codes for 2 Arg residues at the C-terminus that are cleaved to
CC       form the mature peptide, while the other ends in a termination
CC       codon immediately after the last codon of the mature peptide.
CC   -!- DISEASE: Atrial standstill 2 (ATRST2) [MIM:615745]: A rare
CC       arrhythmia characterized by the absence of electrical and
CC       mechanical activity in the atria. Electrocardiographically, it is
CC       characterized by bradycardia, the absence of P waves, and a
CC       junctional narrow complex escape rhythm.
CC       {ECO:0000269|PubMed:23275345}. Note=The disease is caused by
CC       mutations affecting the gene represented in this entry.
CC   -!- DISEASE: Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A
CC       familial form of atrial fibrillation, a common sustained cardiac
CC       rhythm disturbance. Atrial fibrillation is characterized by
CC       disorganized atrial electrical activity and ineffective atrial
CC       contraction promoting blood stasis in the atria and reduces
CC       ventricular filling. It can result in palpitations, syncope,
CC       thromboembolic stroke, and congestive heart failure.
CC       {ECO:0000269|PubMed:18614783}. Note=The disease is caused by
CC       mutations affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Atrial natriuretic peptide
CC       entry;
CC       URL="https://en.wikipedia.org/wiki/Atrial_natriuretic_peptide";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; K02043; AAB59379.1; -; Genomic_DNA.
DR   EMBL; M30262; AAA35669.1; -; mRNA.
DR   EMBL; X01470; CAA25699.1; -; Genomic_DNA.
DR   EMBL; X02558; CAA25699.1; JOINED; Genomic_DNA.
DR   EMBL; X01471; CAA25700.2; -; Genomic_DNA.
DR   EMBL; M54951; AAA35529.1; -; Genomic_DNA.
DR   EMBL; M54947; AAA35529.1; JOINED; Genomic_DNA.
DR   EMBL; AL021155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EU326308; ACA05916.1; -; Genomic_DNA.
DR   EMBL; BC005893; AAH05893.1; -; mRNA.
DR   EMBL; K02399; AAA35528.1; -; Genomic_DNA.
DR   EMBL; K02044; AAA51730.1; -; mRNA.
DR   PIR; A22693; AWHU.
DR   RefSeq; NP_006163.1; NM_006172.3.
DR   UniGene; Hs.75640; -.
DR   PDB; 1ANP; NMR; -; A=124-151.
DR   PDB; 1YK0; X-ray; 2.40 A; E=129-149.
DR   PDB; 3N57; X-ray; 3.03 A; C/D=124-151.
DR   PDBsum; 1ANP; -.
DR   PDBsum; 1YK0; -.
DR   PDBsum; 3N57; -.
DR   DisProt; DP00747; -.
DR   ProteinModelPortal; P01160; -.
DR   SMR; P01160; -.
DR   BioGrid; 110938; 50.
DR   IntAct; P01160; 5.
DR   STRING; 9606.ENSP00000365663; -.
DR   BindingDB; P01160; -.
DR   ChEMBL; CHEMBL1293193; -.
DR   CarbonylDB; P01160; -.
DR   iPTMnet; P01160; -.
DR   PhosphoSitePlus; P01160; -.
DR   BioMuta; NPPA; -.
DR   DMDM; 113864; -.
DR   PaxDb; P01160; -.
DR   PeptideAtlas; P01160; -.
DR   PRIDE; P01160; -.
DR   ProteomicsDB; 51340; -.
DR   DNASU; 4878; -.
DR   Ensembl; ENST00000376480; ENSP00000365663; ENSG00000175206.
DR   GeneID; 4878; -.
DR   KEGG; hsa:4878; -.
DR   UCSC; uc001ati.4; human.
DR   CTD; 4878; -.
DR   DisGeNET; 4878; -.
DR   EuPathDB; HostDB:ENSG00000175206.10; -.
DR   GeneCards; NPPA; -.
DR   H-InvDB; HIX0199955; -.
DR   HGNC; HGNC:7939; NPPA.
DR   HPA; HPA058269; -.
DR   MalaCards; NPPA; -.
DR   MIM; 108780; gene.
DR   MIM; 612201; phenotype.
DR   MIM; 615745; phenotype.
DR   neXtProt; NX_P01160; -.
DR   Orphanet; 1344; Atrial standstill.
DR   Orphanet; 334; Familial atrial fibrillation.
DR   PharmGKB; PA256; -.
DR   eggNOG; ENOG410IW5F; Eukaryota.
DR   eggNOG; ENOG410ZUY6; LUCA.
DR   HOGENOM; HOG000033937; -.
DR   HOVERGEN; HBG004227; -.
DR   InParanoid; P01160; -.
DR   KO; K12334; -.
DR   OrthoDB; 953529at2759; -.
DR   PhylomeDB; P01160; -.
DR   TreeFam; TF106304; -.
DR   Reactome; R-HSA-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR   Reactome; R-HSA-5578768; Physiological factors.
DR   Reactome; R-HSA-977225; Amyloid fiber formation.
DR   SIGNOR; P01160; -.
DR   EvolutionaryTrace; P01160; -.
DR   GeneWiki; Atrial_natriuretic_peptide; -.
DR   GenomeRNAi; 4878; -.
DR   PRO; PR:P01160; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000175206; Expressed in 188 organ(s), highest expression level in cardiac muscle of right atrium.
DR   ExpressionAtlas; P01160; baseline and differential.
DR   Genevisible; P01160; HS.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042629; C:mast cell granule; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IDA:CAFA.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0051427; F:hormone receptor binding; IPI:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IMP:BHF-UCL.
DR   GO; GO:0071855; F:neuropeptide receptor binding; IMP:BHF-UCL.
DR   GO; GO:0005102; F:signaling receptor binding; IDA:UniProtKB.
DR   GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
DR   GO; GO:0061049; P:cell growth involved in cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0006182; P:cGMP biosynthetic process; IDA:GO_Central.
DR   GO; GO:0019934; P:cGMP-mediated signaling; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; ISS:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:1903815; P:negative regulation of collecting lymphatic vessel constriction; IEA:Ensembl.
DR   GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0060452; P:positive regulation of cardiac muscle contraction; IMP:BHF-UCL.
DR   GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IEA:Ensembl.
DR   GO; GO:1902261; P:positive regulation of delayed rectifier potassium channel activity; IDA:BHF-UCL.
DR   GO; GO:0010460; P:positive regulation of heart rate; IMP:BHF-UCL.
DR   GO; GO:1903595; P:positive regulation of histamine secretion by mast cell; IEA:Ensembl.
DR   GO; GO:1903766; P:positive regulation of potassium ion export across plasma membrane; IDA:BHF-UCL.
DR   GO; GO:0006457; P:protein folding; IDA:CAFA.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IDA:UniProtKB.
DR   GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
DR   GO; GO:0008217; P:regulation of blood pressure; IDA:UniProtKB.
DR   GO; GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW.
DR   GO; GO:1902514; P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; ISS:BHF-UCL.
DR   GO; GO:1903779; P:regulation of cardiac conduction; TAS:Reactome.
DR   GO; GO:1901841; P:regulation of high voltage-gated calcium channel activity; ISS:BHF-UCL.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; TAS:BHF-UCL.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002407; Natriuretic_peptide_atrial.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00711; ANATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Atrial fibrillation; Cardiomyopathy; Complete proteome;
KW   Direct protein sequencing; Disease mutation; Disulfide bond; Hormone;
KW   Polymorphism; Reference proteome; Secreted; Signal; Vasoactive.
FT   SIGNAL        1     25       {ECO:0000250|UniProtKB:P24259}.
FT   PROPEP       26    123       {ECO:0000305}.
FT                                /FTId=PRO_0000001493.
FT   PEPTIDE     124    151       Atrial natriuretic factor.
FT                                {ECO:0000269|PubMed:10880574,
FT                                ECO:0000269|PubMed:6230082}.
FT                                /FTId=PRO_0000001494.
FT   SITE        123    124       Cleavage; by CORIN.
FT                                {ECO:0000269|PubMed:10880574}.
FT   SITE        130    131       Cleavage; by MME.
FT                                {ECO:0000269|PubMed:2972276}.
FT   DISULFID    130    146       {ECO:0000269|PubMed:16870210}.
FT   VARIANT      32     32       V -> M (in dbSNP:rs5063).
FT                                /FTId=VAR_014579.
FT   VARIANT     150    150       R -> Q (in ATRST2).
FT                                {ECO:0000269|PubMed:23275345}.
FT                                /FTId=VAR_071307.
FT   VARIANT     152    153       Missing (in allele 2).
FT                                /FTId=VAR_000594.
FT   MUTAGEN     123    123       R->G: Loss of cleavage by CORIN.
FT                                {ECO:0000269|PubMed:10880574}.
FT   CONFLICT     65     65       E -> D (in Ref. 6; AAA35529).
FT                                {ECO:0000305}.
FT   STRAND      139    141       {ECO:0000244|PDB:1YK0}.
SQ   SEQUENCE   153 AA;  16708 MW;  B38F03AA066A73EC CRC64;
     MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK MPLEDEVVPP
     QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG PWDSSDRSAL LKSKLRALLT
     APRSLRRSSC FGGRMDRIGA QSGLGCNSFR YRR
//