ID NGF_HUMAN Reviewed; 241 AA. AC P01138; A1A4E5; Q6FHA0; Q96P60; Q9P2Q8; Q9UKL8; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-MAR-2006, sequence version 3. DT 13-FEB-2019, entry version 203. DE RecName: Full=Beta-nerve growth factor; DE Short=Beta-NGF; DE Flags: Precursor; GN Name=NGF; Synonyms=NGFB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-35. RX PubMed=6688123; DOI=10.1038/303821a0; RA Ullrich A., Gray A., Berman C., Dull T.J.; RT "Human beta-nerve growth factor gene sequence highly homologous to RT that of mouse."; RL Nature 303:821-825(1983). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-35. RX PubMed=6327169; RA Ullrich A., Gray A., Berman C., Coussens L., Dull T.J.; RT "Sequence homology of human and mouse beta-NGF subunit genes."; RL Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1983). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-35. RC TISSUE=Brain; RX PubMed=2374737; DOI=10.1093/nar/18.13.4020; RA Borsani G., Pizzuti A., Rugarli E.I., Falini A., Silani V., Sidoli A., RA Scarlato G., Barelle F.E.; RT "cDNA sequence of human beta-NGF."; RL Nucleic Acids Res. 18:4020-4020(1990). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10322959; RA Tong Y., Wang H., Chen W.; RT "Cloning and sequencing of the gene for premature beta nerve growth RT factor."; RL Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1997). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-35. RX PubMed=15014171; DOI=10.1093/molbev/msh100; RA Kitano T., Liu Y.-H., Ueda S., Saitou N.; RT "Human-specific amino acid changes found in 103 protein-coding RT genes."; RL Mol. Biol. Evol. 21:936-944(2004). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-35. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-35. RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [12] RP NUCLEOTIDE SEQUENCE [MRNA] OF 178-219. RC TISSUE=Leukocyte; RX PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8; RA Hallboeoek F., Ibanez C.F., Persson H.; RT "Evolutionary studies of the nerve growth factor family reveal a novel RT member abundantly expressed in Xenopus ovary."; RL Neuron 6:845-858(1991). RN [13] RP IDENTIFICATION OF NTRK1 AS THE HIGH AFFINITY NGF RECEPTOR. RX PubMed=1849459; DOI=10.1016/0092-8674(91)90419-Y; RA Klein R., Jing S., Nanduri V., O'Rourke E., Barbacid M.; RT "The trk proto-oncogene encodes a receptor for nerve growth factor."; RL Cell 65:189-197(1991). RN [14] RP FUNCTION, AND INTERACTION WITH ADAM10. RX PubMed=20164177; DOI=10.1074/jbc.M110.100479; RA Wijeyewickrema L.C., Gardiner E.E., Gladigau E.L., Berndt M.C., RA Andrews R.K.; RT "Nerve growth factor inhibits metalloproteinase-disintegrins and RT blocks ectodomain shedding of platelet glycoprotein VI."; RL J. Biol. Chem. 285:11793-11799(2010). RN [15] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 122-241, AND DISULFIDE BONDS. RX PubMed=10490030; DOI=10.1038/43705; RA Wiesmann C., Ultsch M.H., Bass S.H., de Vos A.M.; RT "Crystal structure of nerve growth factor in complex with the ligand- RT binding domain of the TrkA receptor."; RL Nature 401:184-188(1999). RN [16] RP VARIANT VAL-35. RX PubMed=10391209; DOI=10.1038/10290; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [17] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). RN [18] RP VARIANT HSAN5 TRP-221. RX PubMed=14976160; DOI=10.1093/hmg/ddh096; RA Einarsdottir E., Carlsson A., Minde J., Toolanen G., Svensson O., RA Solders G., Holmgren G., Holmberg D., Holmberg M.; RT "A mutation in the nerve growth factor beta gene (NGFB) causes loss of RT pain perception."; RL Hum. Mol. Genet. 13:799-805(2004). RN [19] RP CHARACTERIZATION OF VARIANT HSAN5 TRP-221. RX PubMed=20978020; DOI=10.1136/jmg.2010.081455; RA Carvalho O.P., Thornton G.K., Hertecant J., Houlden H., Nicholas A.K., RA Cox J.J., Rielly M., Al-Gazali L., Woods C.G.; RT "A novel NGF mutation clarifies the molecular mechanism and extends RT the phenotypic spectrum of the HSAN5 neuropathy."; RL J. Med. Genet. 48:131-135(2011). RN [20] RP VARIANT HSAN5 GLY-GLU-162 INS, AND VARIANT ASN-187. RX PubMed=22302274; DOI=10.1007/s00415-011-6397-y; RA Davidson G.L., Murphy S.M., Polke J.M., Laura M., Salih M.A., RA Muntoni F., Blake J., Brandner S., Davies N., Horvath R., Price S., RA Donaghy M., Roberts M., Foulds N., Ramdharry G., Soler D., Lunn M.P., RA Manji H., Davis M.B., Houlden H., Reilly M.M.; RT "Frequency of mutations in the genes associated with hereditary RT sensory and autonomic neuropathy in a UK cohort."; RL J. Neurol. 259:1673-1685(2012). CC -!- FUNCTION: Nerve growth factor is important for the development and CC maintenance of the sympathetic and sensory nervous systems. CC Extracellular ligand for the NTRK1 and NGFR receptors, activates CC cellular signaling cascades through those receptor tyrosine kinase CC to regulate neuronal proliferation, differentiation and survival. CC Inhibits metalloproteinase dependent proteolysis of platelet CC glycoprotein VI (PubMed:20164177). {ECO:0000269|PubMed:20164177}. CC -!- SUBUNIT: Homodimer. Interacts with ADAM10 in a divalent cation- CC dependent manner. {ECO:0000269|PubMed:20164177}. CC -!- INTERACTION: CC P08138:NGFR; NbExp=2; IntAct=EBI-1028250, EBI-1387782; CC P07174:Ngfr (xeno); NbExp=3; IntAct=EBI-1028250, EBI-1038810; CC P04629:NTRK1; NbExp=3; IntAct=EBI-1028250, EBI-1028226; CC Q99523:SORT1; NbExp=5; IntAct=EBI-1028250, EBI-1057058; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- DISEASE: Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) CC [MIM:608654]: A form of hereditary sensory and autonomic CC neuropathy, a genetically and clinically heterogeneous group of CC disorders characterized by degeneration of dorsal root and CC autonomic ganglion cells, and by sensory and/or autonomic CC abnormalities. HSAN5 patients manifest loss of pain perception and CC impaired temperature sensitivity, ulcers, and in some cases self- CC mutilation. The autonomic involvement is variable. CC {ECO:0000269|PubMed:14976160, ECO:0000269|PubMed:20978020, CC ECO:0000269|PubMed:22302274}. Note=The disease is caused by CC mutations affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Wikipedia; Note=Nerve growth factor entry; CC URL="https://en.wikipedia.org/wiki/Nerve_growth_factor"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; V01511; CAA24755.1; -; Genomic_DNA. DR EMBL; M21062; AAA59931.1; -; Genomic_DNA. DR EMBL; AF150960; AAD55975.1; -; Genomic_DNA. DR EMBL; AB037517; BAA90437.1; -; Genomic_DNA. DR EMBL; AF411526; AAL05874.1; -; mRNA. DR EMBL; CR541855; CAG46653.1; -; mRNA. DR EMBL; BT019733; AAV38538.1; -; mRNA. DR EMBL; AL049825; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471122; EAW56629.1; -; Genomic_DNA. DR EMBL; BC032517; AAH32517.2; ALT_INIT; mRNA. DR EMBL; BC126148; AAI26149.1; -; mRNA. DR EMBL; BC126150; AAI26151.1; -; mRNA. DR EMBL; X52599; CAA36832.1; -; mRNA. DR CCDS; CCDS882.1; -. DR PIR; A01399; NGHUBM. DR RefSeq; NP_002497.2; NM_002506.2. DR RefSeq; XP_006710726.1; XM_006710663.3. DR UniGene; Hs.2561; -. DR PDB; 1SG1; X-ray; 2.40 A; A/B=122-241. DR PDB; 1WWW; X-ray; 2.20 A; V/W=122-241. DR PDB; 2IFG; X-ray; 3.40 A; E/F=122-241. DR PDB; 4EDW; X-ray; 2.48 A; V=122-241. DR PDB; 4EDX; X-ray; 2.50 A; V/W=122-241. DR PDB; 4ZBN; X-ray; 2.45 A; A/B=122-241. DR PDB; 5JZ7; X-ray; 3.40 A; A/B/E/F=128-237. DR PDBsum; 1SG1; -. DR PDBsum; 1WWW; -. DR PDBsum; 2IFG; -. DR PDBsum; 4EDW; -. DR PDBsum; 4EDX; -. DR PDBsum; 4ZBN; -. DR PDBsum; 5JZ7; -. DR ProteinModelPortal; P01138; -. DR SMR; P01138; -. DR BioGrid; 110869; 6. DR CORUM; P01138; -. DR DIP; DIP-5712N; -. DR IntAct; P01138; 5. DR MINT; P01138; -. DR STRING; 9606.ENSP00000358525; -. DR ChEMBL; CHEMBL1649058; -. DR DrugBank; DB01407; Clenbuterol. DR DrugBank; DB05892; RI 624. DR iPTMnet; P01138; -. DR PhosphoSitePlus; P01138; -. DR BioMuta; NGF; -. DR PaxDb; P01138; -. DR PeptideAtlas; P01138; -. DR PRIDE; P01138; -. DR ProteomicsDB; 51338; -. DR DNASU; 4803; -. DR Ensembl; ENST00000369512; ENSP00000358525; ENSG00000134259. DR GeneID; 4803; -. DR KEGG; hsa:4803; -. DR UCSC; uc001efu.2; human. DR CTD; 4803; -. DR DisGeNET; 4803; -. DR EuPathDB; HostDB:ENSG00000134259.3; -. DR GeneCards; NGF; -. DR GeneReviews; NGF; -. DR HGNC; HGNC:7808; NGF. DR MalaCards; NGF; -. DR MIM; 162030; gene. DR MIM; 608654; phenotype. DR neXtProt; NX_P01138; -. DR OpenTargets; ENSG00000134259; -. DR Orphanet; 64752; Hereditary sensory and autonomic neuropathy type 5. DR PharmGKB; PA162397475; -. DR eggNOG; ENOG410IIPQ; Eukaryota. DR eggNOG; ENOG4111F87; LUCA. DR GeneTree; ENSGT00940000157754; -. DR HOGENOM; HOG000231516; -. DR HOVERGEN; HBG006494; -. DR InParanoid; P01138; -. DR KO; K02582; -. DR OMA; RTKRTAH; -. DR OrthoDB; 1156054at2759; -. DR PhylomeDB; P01138; -. DR TreeFam; TF106463; -. DR Reactome; R-HSA-167021; PLC-gamma1 signalling. DR Reactome; R-HSA-167044; Signalling to RAS. DR Reactome; R-HSA-167060; NGF processing. DR Reactome; R-HSA-170968; Frs2-mediated activation. DR Reactome; R-HSA-170984; ARMS-mediated activation. DR Reactome; R-HSA-177504; Retrograde neurotrophin signalling. DR Reactome; R-HSA-187042; TRKA activation by NGF. DR Reactome; R-HSA-187706; Signalling to p38 via RIT and RIN. DR Reactome; R-HSA-193648; NRAGE signals death through JNK. DR Reactome; R-HSA-193670; p75NTR negatively regulates cell cycle via SC1. DR Reactome; R-HSA-193681; Ceramide signalling. DR Reactome; R-HSA-198203; PI3K/AKT activation. DR Reactome; R-HSA-198745; Signalling to STAT3. DR Reactome; R-HSA-205017; NFG and proNGF binds to p75NTR. DR Reactome; R-HSA-205025; NADE modulates death signalling. DR Reactome; R-HSA-205043; NRIF signals cell death from the nucleus. DR Reactome; R-HSA-209543; p75NTR recruits signalling complexes. DR Reactome; R-HSA-209560; NF-kB is activated and signals survival. DR Reactome; R-HSA-209563; Axonal growth stimulation. DR SignaLink; P01138; -. DR SIGNOR; P01138; -. DR EvolutionaryTrace; P01138; -. DR GeneWiki; Nerve_growth_factor; -. DR GenomeRNAi; 4803; -. DR PMAP-CutDB; P01138; -. DR PRO; PR:P01138; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000134259; Expressed in 96 organ(s), highest expression level in cartilage tissue. DR Genevisible; P01138; HS. DR GO; GO:0030424; C:axon; IBA:GO_Central. DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0030425; C:dendrite; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome. DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central. DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IGI:ARUK-UCL. DR GO; GO:0038177; F:death receptor agonist activity; IGI:ARUK-UCL. DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central. DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IDA:UniProtKB. DR GO; GO:0005163; F:nerve growth factor receptor binding; IPI:BHF-UCL. DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IGI:ARUK-UCL. DR GO; GO:0000186; P:activation of MAPKK activity; TAS:Reactome. DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL. DR GO; GO:0007613; P:memory; IBA:GO_Central. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central. DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome. DR GO; GO:0008285; P:negative regulation of cell population proliferation; TAS:ARUK-UCL. DR GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central. DR GO; GO:0021675; P:nerve development; IBA:GO_Central. DR GO; GO:0032455; P:nerve growth factor processing; TAS:Reactome. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central. DR GO; GO:0051402; P:neuron apoptotic process; IGI:ARUK-UCL. DR GO; GO:0048812; P:neuron projection morphogenesis; IDA:MGI. DR GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central. DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome. DR GO; GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome. DR GO; GO:0050772; P:positive regulation of axonogenesis; TAS:Reactome. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IBA:GO_Central. DR GO; GO:0043388; P:positive regulation of DNA binding; ISS:ARUK-UCL. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB. DR GO; GO:0045666; P:positive regulation of neuron differentiation; TAS:ARUK-UCL. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:ParkinsonsUK-UCL. DR GO; GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome. DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR020425; Nerve_growth_factor_bsu. DR InterPro; IPR020437; Nerve_growth_factor_bsu_mml. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR PANTHER; PTHR11589; PTHR11589; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01925; MAMLNGFBETA. DR PRINTS; PR00268; NGF. DR PRINTS; PR01913; NGFBETA. DR ProDom; PD002052; Nerve_growth_factor-rel; 1. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cleavage on pair of basic residues; Complete proteome; KW Disease mutation; Disulfide bond; Glycoprotein; Growth factor; KW Metalloenzyme inhibitor; Metalloprotease inhibitor; Neurodegeneration; KW Neuropathy; Polymorphism; Protease inhibitor; Reference proteome; KW Secreted; Signal. FT SIGNAL 1 18 {ECO:0000255}. FT PROPEP 19 121 FT /FTId=PRO_0000019599. FT CHAIN 122 241 Beta-nerve growth factor. FT /FTId=PRO_0000019600. FT CARBOHYD 69 69 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 114 114 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 136 201 {ECO:0000269|PubMed:10490030}. FT DISULFID 179 229 {ECO:0000269|PubMed:10490030}. FT DISULFID 189 231 {ECO:0000269|PubMed:10490030}. FT VARIANT 35 35 A -> V (in dbSNP:rs6330). FT {ECO:0000269|PubMed:10391209, FT ECO:0000269|PubMed:15014171, FT ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:2374737, FT ECO:0000269|PubMed:6327169, FT ECO:0000269|PubMed:6688123, FT ECO:0000269|Ref.10}. FT /FTId=VAR_013783. FT VARIANT 72 72 V -> M (in dbSNP:rs11466110). FT /FTId=VAR_025553. FT VARIANT 80 80 R -> Q (in dbSNP:rs11466111). FT /FTId=VAR_025554. FT VARIANT 162 162 E -> EGE (in HSAN5; uncertain FT pathological significance). FT {ECO:0000269|PubMed:22302274}. FT /FTId=VAR_068478. FT VARIANT 187 187 S -> N (found in a patient with FT congenital insensitivity to pain; FT uncertain pathological significance). FT {ECO:0000269|PubMed:22302274}. FT /FTId=VAR_068479. FT VARIANT 221 221 R -> W (in HSAN5; the mutant protein is FT unable to activate the NTRK1 receptor; FT dbSNP:rs11466112). FT {ECO:0000269|PubMed:14976160, FT ECO:0000269|PubMed:20978020}. FT /FTId=VAR_030659. FT CONFLICT 164 164 N -> S (in Ref. 6; AAL05874). FT {ECO:0000305}. FT CONFLICT 230 230 V -> M (in Ref. 6; AAL05874). FT {ECO:0000305}. FT HELIX 127 130 {ECO:0000244|PDB:1WWW}. FT STRAND 133 136 {ECO:0000244|PDB:1WWW}. FT STRAND 138 143 {ECO:0000244|PDB:1WWW}. FT STRAND 148 151 {ECO:0000244|PDB:1WWW}. FT STRAND 156 159 {ECO:0000244|PDB:1WWW}. FT STRAND 161 171 {ECO:0000244|PDB:1WWW}. FT STRAND 174 179 {ECO:0000244|PDB:1WWW}. FT STRAND 190 192 {ECO:0000244|PDB:1SG1}. FT TURN 194 196 {ECO:0000244|PDB:1WWW}. FT STRAND 197 213 {ECO:0000244|PDB:1WWW}. FT STRAND 215 235 {ECO:0000244|PDB:1WWW}. SQ SEQUENCE 241 AA; 26959 MW; 619DFC65EB3BD671 CRC64; MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A //