ID   SG1D1_HUMAN             Reviewed;          90 AA.
AC   O95968;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   13-FEB-2019, entry version 139.
DE   RecName: Full=Secretoglobin family 1D member 1;
DE   AltName: Full=Lipophilin-A;
DE   Flags: Precursor;
GN   Name=SCGB1D1; Synonyms=LIPHA, LPNA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10066439; DOI=10.1006/bbrc.1999.0274;
RA   Zhao C., Nguyen T., Yusifov T., Glasgow B.J., Lehrer R.I.;
RT   "Lipophilins: human peptides homologous to rat prostatein.";
RL   Biochem. Biophys. Res. Commun. 256:147-155(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 22-90, AND MASS SPECTROMETRY.
RX   PubMed=9720917; DOI=10.1016/S0014-5793(98)00852-7;
RA   Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D.,
RA   Glasgow B.J.;
RT   "Lipophilin, a novel heterodimeric protein of human tears.";
RL   FEBS Lett. 432:163-167(1998).
RN   [4]
RP   PROTEIN SEQUENCE OF 22-90, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Tear;
RX   PubMed=25946035; DOI=10.1021/acs.jproteome.5b00179;
RA   Azkargorta M., Soria J., Ojeda C., Guzman F., Acera A., Iloro I.,
RA   Suarez T., Elortza F.;
RT   "Human basal tear peptidome characterization by CID, HCD, and ETD
RT   followed by in silico and in vitro analyses for antimicrobial peptide
RT   identification.";
RL   J. Proteome Res. 14:2649-2658(2015).
CC   -!- FUNCTION: May bind androgens and other steroids, may also bind
CC       estramustine, a chemotherapeutic agent used for prostate cancer.
CC       May be under transcriptional regulation of steroid hormones.
CC   -!- SUBUNIT: Heterodimer of a lipophilin A and a lipophilin C
CC       (mammaglobin B) monomer associated head to head.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in lachrymal gland, thymus, kidney,
CC       testis, ovary and salivary gland.
CC   -!- MASS SPECTROMETRY: Mass=7574.69; Method=Electrospray; Range=22-90;
CC       Evidence={ECO:0000269|PubMed:9720917};
CC   -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AJ224171; CAA11863.1; -; mRNA.
DR   EMBL; BC069170; AAH69170.1; -; mRNA.
DR   EMBL; BC062693; AAH62693.1; -; mRNA.
DR   EMBL; BC069289; AAH69289.1; -; mRNA.
DR   CCDS; CCDS8015.1; -.
DR   RefSeq; NP_006543.1; NM_006552.1.
DR   UniGene; Hs.202686; -.
DR   ProteinModelPortal; O95968; -.
DR   BioGrid; 115892; 78.
DR   IntAct; O95968; 6.
DR   STRING; 9606.ENSP00000303070; -.
DR   iPTMnet; O95968; -.
DR   PhosphoSitePlus; O95968; -.
DR   BioMuta; SCGB1D1; -.
DR   PaxDb; O95968; -.
DR   PeptideAtlas; O95968; -.
DR   PRIDE; O95968; -.
DR   ProteomicsDB; 51149; -.
DR   Ensembl; ENST00000306238; ENSP00000303070; ENSG00000168515.
DR   GeneID; 10648; -.
DR   KEGG; hsa:10648; -.
DR   UCSC; uc001nsz.2; human.
DR   CTD; 10648; -.
DR   EuPathDB; HostDB:ENSG00000168515.3; -.
DR   GeneCards; SCGB1D1; -.
DR   HGNC; HGNC:18395; SCGB1D1.
DR   MIM; 615060; gene.
DR   neXtProt; NX_O95968; -.
DR   OpenTargets; ENSG00000168515; -.
DR   PharmGKB; PA34990; -.
DR   eggNOG; ENOG410KIG7; Eukaryota.
DR   eggNOG; ENOG4110Q9J; LUCA.
DR   GeneTree; ENSGT00530000063866; -.
DR   HOGENOM; HOG000220914; -.
DR   HOVERGEN; HBG006291; -.
DR   InParanoid; O95968; -.
DR   OMA; CANGISF; -.
DR   OrthoDB; 1634878at2759; -.
DR   PhylomeDB; O95968; -.
DR   TreeFam; TF338526; -.
DR   GenomeRNAi; 10648; -.
DR   PRO; PR:O95968; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000168515; Expressed in 17 organ(s), highest expression level in right uterine tube.
DR   Genevisible; O95968; HS.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
DR   CDD; cd00633; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   SUPFAM; SSF48201; SSF48201; 1.
DR   PROSITE; PS51311; SCGB; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     21       {ECO:0000269|PubMed:25946035,
FT                                ECO:0000269|PubMed:9720917}.
FT   CHAIN        22     90       Secretoglobin family 1D member 1.
FT                                /FTId=PRO_0000036378.
SQ   SEQUENCE   90 AA;  9898 MW;  DF2D4F7565A87D34 CRC64;
     MRLSVCLLLL TLALCCYRAN AVVCQALGSE ITGFLLAGKP VFKFQLAKFK APLEAVAAKM
     EVKKCVDTMA YEKRVLITKT LGKIAEKCDR
//