ID   LY66D_HUMAN             Reviewed;         133 AA.
AC   O95868; A2BEY8; B0UXC1; B0V019; B0V1Y6; Q4VX50;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   13-FEB-2019, entry version 119.
DE   RecName: Full=Lymphocyte antigen 6 complex locus protein G6d;
DE            Short=Protein Ly6-D;
DE   AltName: Full=Megakaryocyte-enhanced gene transcript 1 protein;
DE   Flags: Precursor;
GN   Name=LY6G6D; Synonyms=C6orf23, G6D, MEGT1, NG25;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA   Mallya M., Campbell R.D., Aguado B.;
RT   "Transcriptional analysis of a novel cluster of LY-6 family members in
RT   the human and mouse major histocompatibility complex: five genes with
RT   many splice forms.";
RL   Genomics 80:113-123(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10384126;
RA   Ribas G., Neville M., Wixon J.L., Cheng J., Campbell R.D.;
RT   "Genes encoding three new members of the leukocyte antigen 6
RT   superfamily and a novel member of Ig superfamily, together with genes
RT   encoding the regulatory nuclear chloride ion channel protein (hRNCC)
RT   and an N omega-N omega-dimethylarginine dimethylaminohydrolase
RT   homologue, are found in a 30-kb segment of the MHC class III region.";
RL   J. Immunol. 163:278-287(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14656967; DOI=10.1101/gr.1736803;
RA   Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
RA   Campbell R.D., Hood L.;
RT   "Analysis of the gene-dense major histocompatibility complex class III
RT   region and its comparison to mouse.";
RL   Genome Res. 13:2621-2636(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Shiina S., Tamiya G., Oka A., Inoko H.;
RT   "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, AND GPI-ANCHOR.
RX   PubMed=17008713; DOI=10.1110/ps.062242606;
RA   Mallya M., Campbell R.D., Aguado B.;
RT   "Characterization of the five novel Ly-6 superfamily members encoded
RT   in the MHC, and detection of cells expressing their potential
RT   ligands.";
RL   Protein Sci. 15:2244-2256(2006).
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:17008713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713};
CC       Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}. Cell
CC       projection, filopodium {ECO:0000269|PubMed:17008713}.
CC   -!- TISSUE SPECIFICITY: Expressed in the adult lung, and in fetal
CC       liver, lung, kidney, brain and spleen.
CC       {ECO:0000269|PubMed:12079290}.
CC   -!- PTM: O-glycosylated. {ECO:0000269|PubMed:17008713}.
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DR   EMBL; AJ315535; CAC85540.1; -; mRNA.
DR   EMBL; AJ012008; CAB46082.1; -; Genomic_DNA.
DR   EMBL; AF129756; AAD18077.1; -; Genomic_DNA.
DR   EMBL; BA000025; BAB63380.1; -; Genomic_DNA.
DR   EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL670886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX248244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR936239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471081; EAX03486.1; -; Genomic_DNA.
DR   EMBL; BC125138; AAI25139.1; -; mRNA.
DR   CCDS; CCDS34404.1; -.
DR   RefSeq; NP_067069.2; NM_021246.2.
DR   UniGene; Hs.591792; -.
DR   ProteinModelPortal; O95868; -.
DR   BioGrid; 121850; 2.
DR   IntAct; O95868; 1.
DR   STRING; 9606.ENSP00000364985; -.
DR   iPTMnet; O95868; -.
DR   PhosphoSitePlus; O95868; -.
DR   BioMuta; LY6G6D; -.
DR   PaxDb; O95868; -.
DR   PeptideAtlas; O95868; -.
DR   PRIDE; O95868; -.
DR   ProteomicsDB; 51109; -.
DR   Ensembl; ENST00000375825; ENSP00000364985; ENSG00000244355.
DR   Ensembl; ENST00000400080; ENSP00000382952; ENSG00000206402.
DR   Ensembl; ENST00000419389; ENSP00000389619; ENSG00000226603.
DR   Ensembl; ENST00000420378; ENSP00000397576; ENSG00000234443.
DR   Ensembl; ENST00000434515; ENSP00000392651; ENSG00000235302.
DR   Ensembl; ENST00000440095; ENSP00000390777; ENSG00000225993.
DR   Ensembl; ENST00000444880; ENSP00000395722; ENSG00000236902.
DR   GeneID; 58530; -.
DR   KEGG; hsa:58530; -.
DR   UCSC; uc003nwf.1; human.
DR   CTD; 58530; -.
DR   EuPathDB; HostDB:ENSG00000244355.7; -.
DR   GeneCards; LY6G6D; -.
DR   HGNC; HGNC:13935; LY6G6D.
DR   MIM; 606038; gene.
DR   neXtProt; NX_O95868; -.
DR   OpenTargets; ENSG00000244355; -.
DR   PharmGKB; PA37829; -.
DR   eggNOG; ENOG410KG8W; Eukaryota.
DR   eggNOG; ENOG4110SIH; LUCA.
DR   GeneTree; ENSGT00390000015960; -.
DR   HOGENOM; HOG000113412; -.
DR   HOVERGEN; HBG107444; -.
DR   InParanoid; O95868; -.
DR   KO; K06846; -.
DR   OrthoDB; 1493078at2759; -.
DR   PhylomeDB; O95868; -.
DR   Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   GenomeRNAi; 58530; -.
DR   PRO; PR:O95868; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000244355; Expressed in 62 organ(s), highest expression level in colon.
DR   ExpressionAtlas; O95868; baseline and differential.
DR   Genevisible; O95868; HS.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR   GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
DR   InterPro; IPR026524; LY6G6d/LY6G6f.
DR   PANTHER; PTHR32286; PTHR32286; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cell projection; Complete proteome; Disulfide bond;
KW   Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Polymorphism;
KW   Reference proteome; Signal.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    104       Lymphocyte antigen 6 complex locus
FT                                protein G6d.
FT                                /FTId=PRO_0000323707.
FT   PROPEP      105    133       Removed in mature form. {ECO:0000255}.
FT                                /FTId=PRO_0000323708.
FT   DOMAIN       22    116       UPAR/Ly6.
FT   LIPID       104    104       GPI-anchor amidated serine.
FT                                {ECO:0000255}.
FT   CARBOHYD     40     40       O-linked (GalNAc...) threonine.
FT                                {ECO:0000255}.
FT   CARBOHYD     41     41       O-linked (GalNAc...) threonine.
FT                                {ECO:0000255}.
FT   DISULFID     27     35       {ECO:0000250}.
FT   DISULFID     42     71       {ECO:0000250}.
FT   DISULFID     77     96       {ECO:0000250}.
FT   VARIANT       9      9       L -> V (in dbSNP:rs3749952).
FT                                /FTId=VAR_039564.
FT   VARIANT      34     34       S -> T (in dbSNP:rs9267550).
FT                                /FTId=VAR_039565.
SQ   SEQUENCE   133 AA;  13691 MW;  C5CE88EEAFE5F2FD CRC64;
     MKPQFVGILL SSLLGAALGN RMRCYNCGGS PSSSCKEAVT TCGEGRPQPG LEQIKLPGNP
     PVTLIHQHPA CVAAHHCNQV ETESVGDVTY PAHRDCYLGD LCNSAVASHV APAGILAAAA
     TALTCLLPGL WSG
//