ID   LY66C_HUMAN             Reviewed;         125 AA.
AC   O95867; Q5SRS8; Q8IY94;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   13-FEB-2019, entry version 142.
DE   RecName: Full=Lymphocyte antigen 6 complex locus protein G6c;
DE   Flags: Precursor;
GN   Name=LY6G6C; Synonyms=C6orf24, G6C, NG24; ORFNames=UNQ1947/PRO4430;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10384126;
RA   Ribas G., Neville M., Wixon J.L., Cheng J., Campbell R.D.;
RT   "Genes encoding three new members of the leukocyte antigen 6
RT   superfamily and a novel member of Ig superfamily, together with genes
RT   encoding the regulatory nuclear chloride ion channel protein (hRNCC)
RT   and an N omega-N omega-dimethylarginine dimethylaminohydrolase
RT   homologue, are found in a 30-kb segment of the MHC class III region.";
RL   J. Immunol. 163:278-287(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA   Mallya M., Campbell R.D., Aguado B.;
RT   "Transcriptional analysis of a novel cluster of LY-6 family members in
RT   the human and mouse major histocompatibility complex: five genes with
RT   many splice forms.";
RL   Genomics 80:113-123(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14656967; DOI=10.1101/gr.1736803;
RA   Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S.,
RA   Campbell R.D., Hood L.;
RT   "Analysis of the gene-dense major histocompatibility complex class III
RT   region and its comparison to mouse.";
RL   Genome Res. 13:2621-2636(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Shiina S., Tamiya G., Oka A., Inoko H.;
RT   "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, GPI-ANCHOR, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=17008713; DOI=10.1110/ps.062242606;
RA   Mallya M., Campbell R.D., Aguado B.;
RT   "Characterization of the five novel Ly-6 superfamily members encoded
RT   in the MHC, and detection of cells expressing their potential
RT   ligands.";
RL   Protein Sci. 15:2244-2256(2006).
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:17008713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713};
CC       Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}.
CC   -!- TISSUE SPECIFICITY: Highly expressed at the leading edges of
CC       cells, on filopodia. {ECO:0000269|PubMed:17008713}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:17008713}.
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DR   EMBL; AJ012008; CAB46081.1; -; Genomic_DNA.
DR   EMBL; AJ315533; CAC85539.1; -; mRNA.
DR   EMBL; AF129756; AAD18076.1; -; Genomic_DNA.
DR   EMBL; BA000025; BAB63379.1; -; Genomic_DNA.
DR   EMBL; AY359119; AAQ89477.1; -; mRNA.
DR   EMBL; BX248244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR936239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471081; EAX03491.1; -; Genomic_DNA.
DR   EMBL; BC036302; AAH36302.2; -; mRNA.
DR   CCDS; CCDS4714.1; -.
DR   RefSeq; NP_079537.1; NM_025261.2.
DR   UniGene; Hs.732272; -.
DR   ProteinModelPortal; O95867; -.
DR   BioGrid; 123284; 2.
DR   IntAct; O95867; 7.
DR   PhosphoSitePlus; O95867; -.
DR   BioMuta; LY6G6C; -.
DR   PaxDb; O95867; -.
DR   PeptideAtlas; O95867; -.
DR   PRIDE; O95867; -.
DR   ProteomicsDB; 51108; -.
DR   Ensembl; ENST00000375819; ENSP00000364978; ENSG00000204421.
DR   Ensembl; ENST00000383413; ENSP00000372905; ENSG00000206398.
DR   Ensembl; ENST00000419939; ENSP00000388591; ENSG00000235452.
DR   Ensembl; ENST00000428121; ENSP00000411365; ENSG00000228250.
DR   Ensembl; ENST00000428498; ENSP00000410398; ENSG00000228859.
DR   Ensembl; ENST00000434915; ENSP00000415732; ENSG00000236183.
DR   Ensembl; ENST00000448386; ENSP00000409428; ENSG00000235925.
DR   GeneID; 80740; -.
DR   KEGG; hsa:80740; -.
DR   UCSC; uc003nwh.4; human.
DR   CTD; 80740; -.
DR   DisGeNET; 80740; -.
DR   EuPathDB; HostDB:ENSG00000204421.2; -.
DR   GeneCards; LY6G6C; -.
DR   HGNC; HGNC:13936; LY6G6C.
DR   MIM; 610435; gene.
DR   neXtProt; NX_O95867; -.
DR   OpenTargets; ENSG00000204421; -.
DR   PharmGKB; PA37830; -.
DR   eggNOG; ENOG410IZU2; Eukaryota.
DR   eggNOG; ENOG41119SM; LUCA.
DR   GeneTree; ENSGT00390000000752; -.
DR   HOGENOM; HOG000113411; -.
DR   HOVERGEN; HBG052376; -.
DR   InParanoid; O95867; -.
DR   KO; K06846; -.
DR   OMA; TYNTTCC; -.
DR   OrthoDB; 1566894at2759; -.
DR   PhylomeDB; O95867; -.
DR   TreeFam; TF337667; -.
DR   Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   GenomeRNAi; 80740; -.
DR   PRO; PR:O95867; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000204421; Expressed in 113 organ(s), highest expression level in skin of leg.
DR   ExpressionAtlas; O95867; baseline and differential.
DR   Genevisible; O95867; HS.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   InterPro; IPR039237; LY6G6C.
DR   PANTHER; PTHR32149; PTHR32149; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
KW   GPI-anchor; Lipoprotein; Membrane; Polymorphism; Reference proteome;
KW   Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19     99       Lymphocyte antigen 6 complex locus
FT                                protein G6c.
FT                                /FTId=PRO_0000036176.
FT   PROPEP      100    125       Removed in mature form. {ECO:0000255}.
FT                                /FTId=PRO_0000323019.
FT   DOMAIN       20    111       UPAR/Ly6.
FT   LIPID        99     99       GPI-anchor amidated serine.
FT                                {ECO:0000255}.
FT   CARBOHYD     88     88       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     22     47       {ECO:0000250}.
FT   DISULFID     25     33       {ECO:0000250}.
FT   DISULFID     39     65       {ECO:0000250}.
FT   DISULFID     92     97       {ECO:0000250}.
FT   VARIANT      63     63       L -> M (in dbSNP:rs13214568).
FT                                /FTId=VAR_039541.
SQ   SEQUENCE   125 AA;  13821 MW;  9ED7549894C71311 CRC64;
     MKALMLLTLS VLLCWVSADI RCHSCYKVPV LGCVDRQSCR LEPGQQCLTT HAYLGKMWVF
     SNLRCGTPEE PCQEAFNQTN RKLGLTYNTT CCNKDNCNSA GPRPTPALGL VFLTSLAGLG
     LWLLH
//