ID   ANGL1_HUMAN             Reviewed;         491 AA.
AC   O95841; Q5T5Z5;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   13-FEB-2019, entry version 137.
DE   RecName: Full=Angiopoietin-related protein 1;
DE   AltName: Full=Angiopoietin-3;
DE            Short=ANG-3;
DE   AltName: Full=Angiopoietin-like protein 1;
DE   Flags: Precursor;
GN   Name=ANGPTL1; Synonyms=ANG3, ANGPT3, ARP1;
GN   ORFNames=PSEC0154, UNQ162/PRO188;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Heart;
RX   PubMed=10025962; DOI=10.1016/S0014-5793(99)00008-3;
RA   Kim I., Kwak H.J., Ahn J.E., So J.-N., Liu M., Koh K.N., Koh G.Y.;
RT   "Molecular cloning and characterization of a novel angiopoietin family
RT   protein, angiopoietin-3.";
RL   FEBS Lett. 443:353-356(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-
RT   length human cDNAs encoding secretion or membrane proteins from oligo-
RT   capped cDNA libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10025962}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in adrenal gland, placenta,
CC       thyroid gland, heart, skeletal muscle and small intestine. Weakly
CC       expressed in testis, ovary, colon, pancreas, kidney and stomach.
CC       {ECO:0000269|PubMed:10025962}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AF107253; AAD19608.1; -; mRNA.
DR   EMBL; AY358278; AAQ88645.1; -; mRNA.
DR   EMBL; AB056476; BAB40691.1; -; mRNA.
DR   EMBL; AL355520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC050640; AAH50640.1; -; mRNA.
DR   CCDS; CCDS1327.1; -.
DR   RefSeq; NP_004664.1; NM_004673.3.
DR   RefSeq; XP_005245634.1; XM_005245577.2.
DR   UniGene; Hs.591474; -.
DR   ProteinModelPortal; O95841; -.
DR   SMR; O95841; -.
DR   STRING; 9606.ENSP00000234816; -.
DR   iPTMnet; O95841; -.
DR   PhosphoSitePlus; O95841; -.
DR   BioMuta; ANGPTL1; -.
DR   EPD; O95841; -.
DR   jPOST; O95841; -.
DR   PaxDb; O95841; -.
DR   PeptideAtlas; O95841; -.
DR   PRIDE; O95841; -.
DR   ProteomicsDB; 51085; -.
DR   Ensembl; ENST00000234816; ENSP00000234816; ENSG00000116194.
DR   Ensembl; ENST00000367629; ENSP00000356601; ENSG00000116194.
DR   GeneID; 9068; -.
DR   KEGG; hsa:9068; -.
DR   UCSC; uc001gma.4; human.
DR   CTD; 9068; -.
DR   DisGeNET; 9068; -.
DR   EuPathDB; HostDB:ENSG00000116194.12; -.
DR   GeneCards; ANGPTL1; -.
DR   HGNC; HGNC:489; ANGPTL1.
DR   HPA; HPA009976; -.
DR   MIM; 603874; gene.
DR   neXtProt; NX_O95841; -.
DR   OpenTargets; ENSG00000116194; -.
DR   PharmGKB; PA24794; -.
DR   eggNOG; KOG2579; Eukaryota.
DR   eggNOG; ENOG410ZYS4; LUCA.
DR   GeneTree; ENSGT00940000155091; -.
DR   HOGENOM; HOG000037129; -.
DR   HOVERGEN; HBG103336; -.
DR   InParanoid; O95841; -.
DR   OMA; FKDCQHA; -.
DR   OrthoDB; 525245at2759; -.
DR   PhylomeDB; O95841; -.
DR   TreeFam; TF336658; -.
DR   SignaLink; O95841; -.
DR   SIGNOR; O95841; -.
DR   GeneWiki; ANGPTL1; -.
DR   GenomeRNAi; 9068; -.
DR   PRO; PR:O95841; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000116194; Expressed in 168 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; O95841; baseline and differential.
DR   Genevisible; O95841; HS.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl.
DR   CDD; cd00087; FReD; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    491       Angiopoietin-related protein 1.
FT                                /FTId=PRO_0000009118.
FT   DOMAIN      271    491       Fibrinogen C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00739}.
FT   COILED       80    168       {ECO:0000255}.
FT   CARBOHYD    160    160       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    280    309       {ECO:0000255|PROSITE-ProRule:PRU00739}.
FT   DISULFID    432    445       {ECO:0000255|PROSITE-ProRule:PRU00739}.
SQ   SEQUENCE   491 AA;  56720 MW;  3C4DB8DEF6CF7E99 CRC64;
     MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI
     TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR
     KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA
     SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ
     RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN
     SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS
     NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT
     LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL
     RAVQMMIKPI D
//