ID PPN_HUMAN Reviewed; 1278 AA. AC O95428; B4DES8; B4DGE6; Q659F2; Q6UXJ4; Q6ZNM1; Q6ZUJ0; Q7Z681; AC Q8IVU0; DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot. DT 07-JUL-2009, sequence version 4. DT 13-FEB-2019, entry version 136. DE RecName: Full=Papilin; DE Flags: Precursor; GN Name=PAPLN; ORFNames=UNQ2420/PRO4977; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT RP MET-1201. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 800-1217 (ISOFORM 4). RC TISSUE=Amygdala, Cerebellum, and Synovial cell; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-896. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-302 (ISOFORM 6), AND RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-1278 (ISOFORM 1). RC TISSUE=Liver, and Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1278 (ISOFORM 1). RC TISSUE=Spleen; RA Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.; RT "The nucleotide sequence of a long cDNA clone isolated from human RT spleen."; RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=6; CC Name=1; CC IsoId=O95428-1; Sequence=Displayed; CC Name=2; CC IsoId=O95428-2; Sequence=VSP_032269, VSP_032272; CC Note=No experimental confirmation available.; CC Name=5; CC IsoId=O95428-5; Sequence=VSP_037596; CC Name=6; CC IsoId=O95428-6; Sequence=VSP_037595; CC Note=No experimental confirmation available.; CC Name=3; CC IsoId=O95428-3; Sequence=VSP_032270, VSP_032271; CC Note=No experimental confirmation available.; CC Name=4; CC IsoId=O95428-4; Sequence=VSP_032273, VSP_032274; CC Note=No experimental confirmation available.; CC -!- SIMILARITY: Belongs to the papilin family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC97963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=BAC86235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC Sequence=BAG57189.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; CC Sequence=BAG57189.1; Type=Erroneous termination; Positions=1216; Note=Translated as Glu.; Evidence={ECO:0000305}; CC Sequence=BAG57757.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; CC Sequence=CAH56406.1; Type=Miscellaneous discrepancy; Note=Partially unspliced mRNA.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY358330; AAQ88696.1; -; mRNA. DR EMBL; AK125658; BAC86235.1; ALT_INIT; mRNA. DR EMBL; AK294560; BAG57757.1; ALT_INIT; mRNA. DR EMBL; AK293773; BAG57189.1; ALT_SEQ; mRNA. DR EMBL; AC004846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF109907; AAC97963.1; ALT_SEQ; Genomic_DNA. DR EMBL; BC042057; AAH42057.1; -; mRNA. DR EMBL; AL110280; CAH56406.1; ALT_SEQ; mRNA. DR EMBL; BX470414; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BX537757; CAD97826.1; -; mRNA. DR EMBL; AK131073; BAC85123.1; -; mRNA. DR CCDS; CCDS32114.1; -. [O95428-6] DR RefSeq; NP_775733.3; NM_173462.3. [O95428-6] DR RefSeq; XP_011535592.1; XM_011537290.2. [O95428-1] DR RefSeq; XP_011535593.1; XM_011537291.2. [O95428-1] DR RefSeq; XP_011535594.1; XM_011537292.2. [O95428-1] DR UniGene; Hs.509909; -. DR ProteinModelPortal; O95428; -. DR SMR; O95428; -. DR BioGrid; 124645; 11. DR IntAct; O95428; 1. DR STRING; 9606.ENSP00000345395; -. DR MEROPS; I02.972; -. DR iPTMnet; O95428; -. DR PhosphoSitePlus; O95428; -. DR BioMuta; PAPLN; -. DR jPOST; O95428; -. DR PaxDb; O95428; -. DR PeptideAtlas; O95428; -. DR PRIDE; O95428; -. DR ProteomicsDB; 50869; -. DR ProteomicsDB; 50870; -. [O95428-2] DR ProteomicsDB; 50871; -. [O95428-3] DR ProteomicsDB; 50872; -. [O95428-4] DR ProteomicsDB; 50873; -. [O95428-5] DR ProteomicsDB; 50874; -. [O95428-6] DR Ensembl; ENST00000340738; ENSP00000345395; ENSG00000100767. [O95428-6] DR Ensembl; ENST00000554301; ENSP00000451803; ENSG00000100767. [O95428-1] DR Ensembl; ENST00000555445; ENSP00000451729; ENSG00000100767. [O95428-5] DR Ensembl; ENST00000644200; ENSP00000495882; ENSG00000100767. [O95428-1] DR GeneID; 89932; -. DR KEGG; hsa:89932; -. DR UCSC; uc001xnw.5; human. [O95428-1] DR CTD; 89932; -. DR DisGeNET; 89932; -. DR EuPathDB; HostDB:ENSG00000100767.15; -. DR GeneCards; PAPLN; -. DR H-InvDB; HIX0019543; -. DR H-InvDB; HIX0037927; -. DR HGNC; HGNC:19262; PAPLN. DR HPA; HPA048682; -. DR HPA; HPA053453; -. DR MIM; 617785; gene. DR neXtProt; NX_O95428; -. DR OpenTargets; ENSG00000100767; -. DR PharmGKB; PA134914395; -. DR eggNOG; KOG3510; Eukaryota. DR eggNOG; KOG4597; Eukaryota. DR eggNOG; ENOG410XQNP; LUCA. DR GeneTree; ENSGT00940000156891; -. DR HOVERGEN; HBG108281; -. DR InParanoid; O95428; -. DR OMA; WTIEAAR; -. DR OrthoDB; 56186at2759; -. DR PhylomeDB; O95428; -. DR TreeFam; TF316874; -. DR ChiTaRS; PAPLN; human. DR GeneWiki; PAPLN; -. DR GenomeRNAi; 89932; -. DR PRO; PR:O95428; -. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000100767; Expressed in 176 organ(s), highest expression level in tendon. DR ExpressionAtlas; O95428; baseline and differential. DR Genevisible; O95428; HS. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008233; F:peptidase activity; IEA:InterPro. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR CDD; cd00109; KU; 1. DR Gene3D; 2.20.100.10; -; 5. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 4.10.410.10; -; 1. DR InterPro; IPR010294; ADAM_spacer1. DR InterPro; IPR013273; ADAMTS/ADAMTS-like. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR002223; Kunitz_BPTI. DR InterPro; IPR036880; Kunitz_BPTI_sf. DR InterPro; IPR010909; PLAC. DR InterPro; IPR020901; Prtase_inh_Kunz-CS. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR Pfam; PF05986; ADAM_spacer1; 1. DR Pfam; PF07679; I-set; 2. DR Pfam; PF00014; Kunitz_BPTI; 1. DR Pfam; PF08686; PLAC; 1. DR Pfam; PF00090; TSP_1; 5. DR PRINTS; PR01857; ADAMTSFAMILY. DR PRINTS; PR00759; BASICPTASE. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00406; IGv; 3. DR SMART; SM00131; KU; 1. DR SMART; SM00209; TSP1; 5. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF57362; SSF57362; 1. DR SUPFAM; SSF82895; SSF82895; 5. DR PROSITE; PS00280; BPTI_KUNITZ_1; 1. DR PROSITE; PS50279; BPTI_KUNITZ_2; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50900; PLAC; 1. DR PROSITE; PS50092; TSP1; 5. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Disulfide bond; KW Immunoglobulin domain; Polymorphism; Protease inhibitor; KW Reference proteome; Repeat; Secreted; Serine protease inhibitor; KW Signal. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 1278 Papilin. FT /FTId=PRO_0000324550. FT DOMAIN 26 80 TSP type-1 1. {ECO:0000255|PROSITE- FT ProRule:PRU00210}. FT DOMAIN 304 361 TSP type-1 2. {ECO:0000255|PROSITE- FT ProRule:PRU00210}. FT DOMAIN 362 421 TSP type-1 3. {ECO:0000255|PROSITE- FT ProRule:PRU00210}. FT DOMAIN 423 481 TSP type-1 4. {ECO:0000255|PROSITE- FT ProRule:PRU00210}. FT DOMAIN 484 539 TSP type-1 5. {ECO:0000255|PROSITE- FT ProRule:PRU00210}. FT DOMAIN 754 804 BPTI/Kunitz inhibitor. FT {ECO:0000255|PROSITE-ProRule:PRU00031}. FT DOMAIN 900 995 Ig-like C2-type 1. FT DOMAIN 1033 1128 Ig-like C2-type 2. FT DOMAIN 1133 1218 Ig-like C2-type 3. FT DOMAIN 1231 1270 PLAC. {ECO:0000255|PROSITE- FT ProRule:PRU00233}. FT DISULFID 38 74 {ECO:0000250}. FT DISULFID 42 79 {ECO:0000250}. FT DISULFID 53 64 {ECO:0000250}. FT DISULFID 316 355 {ECO:0000250}. FT DISULFID 320 360 {ECO:0000250}. FT DISULFID 331 343 {ECO:0000250}. FT DISULFID 754 804 {ECO:0000250}. FT DISULFID 763 787 {ECO:0000250}. FT DISULFID 779 800 {ECO:0000250}. FT DISULFID 931 978 {ECO:0000250}. FT DISULFID 1065 1112 {ECO:0000250}. FT DISULFID 1154 1202 {ECO:0000250}. FT VAR_SEQ 1 801 Missing (in isoform 2). FT {ECO:0000303|PubMed:12975309}. FT /FTId=VSP_032269. FT VAR_SEQ 124 129 GENFYY -> VLGLQA (in isoform 3). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_032270. FT VAR_SEQ 130 1278 Missing (in isoform 3). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_032271. FT VAR_SEQ 197 223 Missing (in isoform 6). FT {ECO:0000303|PubMed:17974005}. FT /FTId=VSP_037595. FT VAR_SEQ 749 764 Missing (in isoform 5). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_037596. FT VAR_SEQ 802 907 SSCQGSLHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHR FT TGAAVQRKPWPSGGLWRQDQQPGPGEAPHTQAFGEWPWGQE FT LGSRAPGLGGDAGSPAPPFHSSSY -> MGPVVPSLGLLEG FT APTRMVAAAVLQASRNPASTGQGPRCRESPGLLVVSGGKTN FT SLGQGRPPTPRPLENGHGGRSLGPGPLDWVEMPDHQRHPST FT APPTDLTSHLS (in isoform 2). FT {ECO:0000303|PubMed:12975309}. FT /FTId=VSP_032272. FT VAR_SEQ 1088 1109 RHQLQPDGSLVISRVAVEDGGF -> STHRPAQGPWQGLRR FT PARAGQL (in isoform 4). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_032273. FT VAR_SEQ 1110 1278 Missing (in isoform 4). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_032274. FT VARIANT 33 33 S -> G (in dbSNP:rs2280792). FT /FTId=VAR_039815. FT VARIANT 191 191 A -> T (in dbSNP:rs741842). FT /FTId=VAR_039816. FT VARIANT 356 356 N -> H (in dbSNP:rs17126331). FT /FTId=VAR_039817. FT VARIANT 443 443 V -> I (in dbSNP:rs17126352). FT /FTId=VAR_039818. FT VARIANT 461 461 A -> V (in dbSNP:rs17126354). FT /FTId=VAR_039819. FT VARIANT 628 628 H -> R (in dbSNP:rs17182244). FT /FTId=VAR_039820. FT VARIANT 723 723 Q -> H (in dbSNP:rs2242616). FT /FTId=VAR_039821. FT VARIANT 896 896 G -> R (in dbSNP:rs177386). FT {ECO:0000269|PubMed:12508121}. FT /FTId=VAR_039822. FT VARIANT 1192 1192 L -> V (in dbSNP:rs2107731). FT /FTId=VAR_039823. FT VARIANT 1201 1201 T -> M (in dbSNP:rs4903104). FT {ECO:0000269|PubMed:12975309}. FT /FTId=VAR_039824. FT VARIANT 1260 1260 S -> T (in dbSNP:rs11626824). FT /FTId=VAR_039825. FT CONFLICT 326 326 S -> P (in Ref. 2; BAG57757). FT {ECO:0000305}. FT CONFLICT 693 693 M -> R (in Ref. 2; BAG57757, 5; CAD97826 FT and 6; BAC85123). {ECO:0000305}. FT CONFLICT 1162 1162 N -> D (in Ref. 2; BAG57189). FT {ECO:0000305}. FT CONFLICT 1229 1229 R -> K (in Ref. 5; CAD97826). FT {ECO:0000305}. SQ SEQUENCE 1278 AA; 137700 MW; A8DED3CADB0D70C1 CRC64; MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT TCYPVAGTFD ANDLSRGYNQ ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI EAARALPAAS TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA DRRSCNLHPC PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA VEEAECAGLP GKPPAIQACN LQRCAAWSPE PWGECSVSCG VGVRKRSVTC RGERGSLLHT AACSLEDRPP LTEPCVHEDC PLLSDQAWHV GTWGLCSKSC SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL PQEVPSMQDV HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW QGCPGAPCQQ SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA STVHNTHQPQ AQQNEPSECR GSQFGCCYDN VATAAGPLGE GCVGQPSHAY PVRCLLPSAH GSCADWAARW YFVASVGQCN RFWYGGCHGN ANNFASEQEC MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ HRTGAAVQRK PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI SSDRHRLQFD GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA VLSEAELSRF PQPRDPAQDF GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP RVVDASPGQR IRMTCRAEGF PPPAIEWQRD GQPVSSPRHQ LQPDGSLVIS RVAVEDGGFY TCVAFNGQDR DQRWVQLRVL GELTISGLPP TVTVPEGDTA RLLCVVAGES VNIRWSRNGL PVQADGHRVH QSPDGTLLIY NLRARDEGSY TCSAYQGSQA VSRSTEVKVV SPAPTAQPRD PGRDCVDQPE LANCDLILQA QLCGNEYYSS FCCASCSRFQ PHAQPIWQ //