ID TNF6B_HUMAN Reviewed; 300 AA. AC O95407; DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 13-FEB-2019, entry version 150. DE RecName: Full=Tumor necrosis factor receptor superfamily member 6B; DE AltName: Full=Decoy receptor 3; DE Short=DcR3; DE AltName: Full=Decoy receptor for Fas ligand; DE AltName: Full=M68; DE Flags: Precursor; GN Name=TNFRSF6B; Synonyms=DCR3, TR6; ORFNames=UNQ186/PRO212; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Fetal lung; RX PubMed=9872321; DOI=10.1038/25387; RA Pitti R.M., Marsters S.A., Lawrence D.A., Roy M., Kischkel F.C., RA Dowd P., Huang A., Donahue C.J., Sherwood S.W., Baldwin D.T., RA Godowski P.J., Wood W.I., Gurney A.L., Hillan K.J., Cohen R.L., RA Goddard A.D., Botstein D., Ashkenazi A.; RT "Genomic amplification of a decoy receptor for Fas ligand in lung and RT colon cancer."; RL Nature 396:699-703(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 30-35. RC TISSUE=Prostate; RX PubMed=10318773; DOI=10.1074/jbc.274.20.13733; RA Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S.; RT "A newly identified member of tumor necrosis factor receptor RT superfamily (TR6) suppresses LIGHT-mediated apoptosis."; RL J. Biol. Chem. 274:13733-13736(1999). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC TISSUE=Lung; RX PubMed=10655513; DOI=10.1073/pnas.97.3.1230; RA Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., RA Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.; RT "Overexpression of M68/DcR3 in human gastrointestinal tract tumors RT independent of gene amplification and its location in a four-gene RT cluster."; RL Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung, and Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 30-195 IN COMPLEX WITH RP TNFSF15, FUNCTION, AND DISULFIDE BONDS. RX PubMed=21300286; DOI=10.1016/j.str.2010.12.004; RA Zhan C., Patskovsky Y., Yan Q., Li Z., Ramagopal U., Cheng H., RA Brenowitz M., Hui X., Nathenson S.G., Almo S.C.; RT "Decoy strategies: the structure of TL1A:DcR3 complex."; RL Structure 19:162-171(2011). CC -!- FUNCTION: Decoy receptor that can neutralize the cytotoxic ligands CC TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. CC {ECO:0000269|PubMed:21300286}. CC -!- INTERACTION: CC P60411:KRTAP10-9; NbExp=3; IntAct=EBI-524171, EBI-10172052; CC O43557:TNFSF14; NbExp=2; IntAct=EBI-524171, EBI-524131; CC O43557-1:TNFSF14; NbExp=4; IntAct=EBI-524171, EBI-15910661; CC O95150-1:TNFSF15; NbExp=3; IntAct=EBI-524171, EBI-15910629; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Detected in fetal lung, brain and liver. CC Detected in adult stomach, spinal cord, lymph node, trachea, CC spleen, colon and lung. Highly expressed in several primary tumors CC from colon, stomach, rectum, esophagus and in SW480 colon CC carcinoma cells. CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology CC and Haematology; CC URL="http://atlasgeneticsoncology.org/Genes/TNFRSF6BID42628ch20q13.html"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF104419; AAD03056.1; -; mRNA. DR EMBL; AF134240; AAD29688.1; -; mRNA. DR EMBL; AF217796; AAF35244.1; -; Genomic_DNA. DR EMBL; AF217793; AAF33685.1; -; mRNA. DR EMBL; AF217794; AAF33686.1; -; mRNA. DR EMBL; AY358279; AAQ88646.1; -; mRNA. DR EMBL; AL121845; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC017065; AAH17065.1; -; mRNA. DR EMBL; BC034349; AAH34349.1; -; mRNA. DR CCDS; CCDS13532.1; -. DR RefSeq; NP_003814.1; NM_003823.3. DR UniGene; Hs.434878; -. DR PDB; 3K51; X-ray; 2.45 A; B=30-195. DR PDB; 3MHD; X-ray; 2.90 A; D=30-195. DR PDB; 3MI8; X-ray; 2.95 A; D=30-195. DR PDB; 4J6G; X-ray; 2.40 A; C/D=30-195. DR PDB; 4KGG; X-ray; 2.78 A; C/D=30-195. DR PDB; 4KGQ; X-ray; 2.27 A; C/D=30-195. DR PDB; 4MSV; X-ray; 2.50 A; B=30-195. DR PDB; 5L36; X-ray; 3.10 A; B=30-195. DR PDBsum; 3K51; -. DR PDBsum; 3MHD; -. DR PDBsum; 3MI8; -. DR PDBsum; 4J6G; -. DR PDBsum; 4KGG; -. DR PDBsum; 4KGQ; -. DR PDBsum; 4MSV; -. DR PDBsum; 5L36; -. DR ProteinModelPortal; O95407; -. DR SMR; O95407; -. DR BioGrid; 114301; 6. DR IntAct; O95407; 5. DR STRING; 9606.ENSP00000359013; -. DR iPTMnet; O95407; -. DR PhosphoSitePlus; O95407; -. DR BioMuta; TNFRSF6B; -. DR EPD; O95407; -. DR jPOST; O95407; -. DR PaxDb; O95407; -. DR PeptideAtlas; O95407; -. DR PRIDE; O95407; -. DR ProteomicsDB; 50860; -. DR Ensembl; ENST00000369996; ENSP00000359013; ENSG00000243509. DR GeneID; 8771; -. DR KEGG; hsa:8771; -. DR UCSC; uc002yfz.4; human. DR CTD; 8771; -. DR DisGeNET; 8771; -. DR EuPathDB; HostDB:ENSG00000243509.4; -. DR GeneCards; TNFRSF6B; -. DR HGNC; HGNC:11921; TNFRSF6B. DR HPA; HPA047154; -. DR MIM; 603361; gene. DR neXtProt; NX_O95407; -. DR OpenTargets; ENSG00000243509; -. DR PharmGKB; PA36614; -. DR eggNOG; ENOG410IH0F; Eukaryota. DR eggNOG; ENOG410YF4X; LUCA. DR GeneTree; ENSGT00940000162635; -. DR HOGENOM; HOG000154657; -. DR InParanoid; O95407; -. DR KO; K05143; -. DR OMA; NVICGER; -. DR OrthoDB; 869160at2759; -. DR TreeFam; TF331157; -. DR Reactome; R-HSA-5669034; TNFs bind their physiological receptors. DR SIGNOR; O95407; -. DR EvolutionaryTrace; O95407; -. DR GeneWiki; TNFRSF6B; -. DR GenomeRNAi; 8771; -. DR PRO; PR:O95407; -. DR Proteomes; UP000005640; Chromosome 20. DR Bgee; ENSG00000243509; Expressed in 80 organ(s), highest expression level in substantia nigra. DR Genevisible; O95407; HS. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; NAS:UniProtKB. DR GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc. DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome. DR CDD; cd10575; TNFRSF6B; 1. DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg. DR InterPro; IPR034023; TNFRSF6B_N. DR Pfam; PF00020; TNFR_c6; 3. DR SMART; SM00208; TNFR; 4. DR PROSITE; PS00652; TNFR_NGFR_1; 1. DR PROSITE; PS50050; TNFR_NGFR_2; 2. PE 1: Evidence at protein level; KW 3D-structure; Apoptosis; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; Receptor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 29 {ECO:0000269|PubMed:10318773}. FT CHAIN 30 300 Tumor necrosis factor receptor FT superfamily member 6B. FT /FTId=PRO_0000034570. FT REPEAT 31 70 TNFR-Cys 1. FT REPEAT 72 113 TNFR-Cys 2. FT REPEAT 115 150 TNFR-Cys 3. FT REPEAT 152 193 TNFR-Cys 4. FT CARBOHYD 173 173 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 49 62 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 52 70 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 73 88 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 91 105 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 95 113 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 115 126 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 132 150 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 153 168 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT DISULFID 174 193 {ECO:0000255|PROSITE-ProRule:PRU00206, FT ECO:0000269|PubMed:21300286}. FT STRAND 35 39 {ECO:0000244|PDB:4KGQ}. FT TURN 41 43 {ECO:0000244|PDB:4KGQ}. FT STRAND 46 50 {ECO:0000244|PDB:4KGQ}. FT STRAND 56 60 {ECO:0000244|PDB:4KGQ}. FT STRAND 64 66 {ECO:0000244|PDB:4KGQ}. FT STRAND 69 72 {ECO:0000244|PDB:4KGQ}. FT STRAND 81 83 {ECO:0000244|PDB:4KGQ}. FT STRAND 99 103 {ECO:0000244|PDB:4KGQ}. FT STRAND 107 109 {ECO:0000244|PDB:3MI8}. FT STRAND 112 115 {ECO:0000244|PDB:4KGQ}. FT STRAND 119 122 {ECO:0000244|PDB:4KGQ}. FT STRAND 125 128 {ECO:0000244|PDB:4KGQ}. FT STRAND 136 140 {ECO:0000244|PDB:4KGQ}. FT STRAND 144 146 {ECO:0000244|PDB:4KGQ}. FT STRAND 149 152 {ECO:0000244|PDB:4KGQ}. FT STRAND 163 165 {ECO:0000244|PDB:4KGQ}. FT HELIX 174 177 {ECO:0000244|PDB:4KGQ}. FT STRAND 181 183 {ECO:0000244|PDB:4KGQ}. FT STRAND 186 189 {ECO:0000244|PDB:3K51}. FT STRAND 191 193 {ECO:0000244|PDB:3K51}. SQ SEQUENCE 300 AA; 32680 MW; F90AEE33718449AF CRC64; MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH //