ID   LYPD3_HUMAN             Reviewed;         346 AA.
AC   O95274; Q9UJ74;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   13-FEB-2019, entry version 116.
DE   RecName: Full=Ly6/PLAUR domain-containing protein 3;
DE   AltName: Full=GPI-anchored metastasis-associated protein C4.4A homolog;
DE   AltName: Full=Matrigel-induced gene C4 protein;
DE            Short=MIG-C4;
DE   Flags: Precursor;
GN   Name=LYPD3; Synonyms=C4.4A; ORFNames=UNQ491/PRO1007;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Urothelium;
RX   PubMed=11245483;
RA   Smith B.A., Kennedy W.J., Harnden P., Selby P.J., Trejdosiewicz L.K.,
RA   Southgate J.;
RT   "Identification of genes involved in human urothelial cell-matrix
RT   interactions: implications for the progression pathways of malignant
RT   urothelium.";
RL   Cancer Res. 61:1678-1685(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Placenta;
RX   PubMed=11179665; DOI=10.1016/S0378-1119(00)00515-1;
RA   Wuerfel J., Seiter S., Stassar M., Claas A., Klaes R., Roesel M.,
RA   Marhaba R., Savelyeva L., Schwab M., Matzku S., Zoeller M.;
RT   "Cloning of the human homologue of the metastasis-associated rat
RT   C4.4A.";
RL   Gene 262:35-41(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 196-216, FUNCTION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, GLYCOSYLATION, AND GPI-ANCHOR.
RX   PubMed=15012588; DOI=10.1042/BJ20031478;
RA   Hansen L.V., Gaardsvoll H., Nielsen B.S., Lund L.R., Danoe K.,
RA   Jensen O.N., Ploug M.;
RT   "Structural analysis and tissue localization of human C4.4A: a protein
RT   homologue of the urokinase receptor.";
RL   Biochem. Eng. J. 380:845-857(2004).
RN   [7]
RP   FUNCTION, TISSUE SPECIFICITY, AND INTERACTION WITH AGR2 AND AGR3.
RX   PubMed=12592373; DOI=10.1038/sj.bjc.6600740;
RA   Fletcher G.C., Patel S., Tyson K., Adam P.J., Schenker M.,
RA   Loader J.A., Daviet L., Legrain P., Parekh R., Harris A.L.,
RA   Terrett J.A.;
RT   "hAG-2 and hAG-3, human homologues of genes involved in
RT   differentiation, are associated with oestrogen receptor-positive
RT   breast tumours and interact with metastasis gene C4.4a and
RT   dystroglycan.";
RL   Br. J. Cancer 88:579-585(2003).
CC   -!- FUNCTION: Supports cell migration. May be involved in urothelial
CC       cell-matrix interactions. May be involved in tumor progression.
CC       {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:11245483,
CC       ECO:0000269|PubMed:12592373, ECO:0000269|PubMed:15012588}.
CC   -!- SUBUNIT: Binds laminin-1 and laminin-5. Interacts with LGALS3 (By
CC       similarity). Interacts with AGR2 and AGR3. {ECO:0000250,
CC       ECO:0000269|PubMed:12592373}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- TISSUE SPECIFICITY: Expressed in placenta, skin and urothelium.
CC       Found in suprabasal keratinocytes of chronic wounds. Weak
CC       expression is found in esophagus and peripheral blood mononuclear
CC       cells. Found in the majority of primary and metastatic
CC       transitional cell carcinomas (TCCs) and as well in breast cancer
CC       tissues, but not in adjacent normal tissues. High expression is
CC       found in the tumor component of some noninvasive superficial
CC       lesions and in invasive and metastatic urothelial cancers.
CC       {ECO:0000269|PubMed:11179665, ECO:0000269|PubMed:12592373,
CC       ECO:0000269|PubMed:15012588}.
CC   -!- INDUCTION: Up-regulated in migrating keratinocytes during
CC       epithelisation of incisional skin wounds.
CC   -!- PTM: N-glycosylated and O-glycosylated.
CC       {ECO:0000269|PubMed:15012588}.
CC   -!- MASS SPECTROMETRY: Mass=21442.9; Method=MALDI; Range=1-204;
CC       Evidence={ECO:0000269|PubMed:15012588};
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/LYPD3ID44245ch19q13.html";
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DR   EMBL; AF082889; AAD13751.1; -; mRNA.
DR   EMBL; AJ223603; CAA11469.2; -; mRNA.
DR   EMBL; AY359006; AAQ89365.1; -; mRNA.
DR   EMBL; AC018758; AAG09062.1; -; Genomic_DNA.
DR   EMBL; BC039167; AAH39167.1; -; mRNA.
DR   CCDS; CCDS12620.1; -.
DR   RefSeq; NP_055215.2; NM_014400.2.
DR   UniGene; Hs.631594; -.
DR   ProteinModelPortal; O95274; -.
DR   BioGrid; 117985; 118.
DR   IntAct; O95274; 16.
DR   MINT; O95274; -.
DR   STRING; 9606.ENSP00000244333; -.
DR   iPTMnet; O95274; -.
DR   PhosphoSitePlus; O95274; -.
DR   BioMuta; LYPD3; -.
DR   EPD; O95274; -.
DR   jPOST; O95274; -.
DR   MaxQB; O95274; -.
DR   PaxDb; O95274; -.
DR   PeptideAtlas; O95274; -.
DR   PRIDE; O95274; -.
DR   ProteomicsDB; 50778; -.
DR   DNASU; 27076; -.
DR   Ensembl; ENST00000244333; ENSP00000244333; ENSG00000124466.
DR   GeneID; 27076; -.
DR   KEGG; hsa:27076; -.
DR   UCSC; uc002owl.2; human.
DR   CTD; 27076; -.
DR   DisGeNET; 27076; -.
DR   EuPathDB; HostDB:ENSG00000124466.8; -.
DR   GeneCards; LYPD3; -.
DR   HGNC; HGNC:24880; LYPD3.
DR   HPA; HPA041529; -.
DR   HPA; HPA041797; -.
DR   HPA; HPA077859; -.
DR   MIM; 609484; gene.
DR   neXtProt; NX_O95274; -.
DR   OpenTargets; ENSG00000124466; -.
DR   PharmGKB; PA142671490; -.
DR   eggNOG; ENOG410IIUT; Eukaryota.
DR   eggNOG; ENOG41116C6; LUCA.
DR   GeneTree; ENSGT00940000153599; -.
DR   HOGENOM; HOG000059631; -.
DR   HOVERGEN; HBG053008; -.
DR   InParanoid; O95274; -.
DR   OMA; CSPHKMK; -.
DR   OrthoDB; 1102918at2759; -.
DR   PhylomeDB; O95274; -.
DR   TreeFam; TF337983; -.
DR   Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   ChiTaRS; LYPD3; human.
DR   GeneWiki; LYPD3; -.
DR   GenomeRNAi; 27076; -.
DR   PRO; PR:O95274; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000124466; Expressed in 125 organ(s), highest expression level in esophagus mucosa.
DR   Genevisible; O95274; HS.
DR   GO; GO:0046658; C:anchored component of plasma membrane; TAS:HGNC.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043236; F:laminin binding; IBA:GO_Central.
DR   GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   Pfam; PF00021; UPAR_LY6; 2.
DR   SMART; SM00134; LU; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Direct protein sequencing;
KW   Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Reference proteome;
KW   Repeat; Signal.
FT   SIGNAL        1     30       {ECO:0000255}.
FT   CHAIN        31    326       Ly6/PLAUR domain-containing protein 3.
FT                                /FTId=PRO_0000226751.
FT   PROPEP      327    346       Removed in mature form. {ECO:0000255}.
FT                                /FTId=PRO_0000226752.
FT   DOMAIN       33    126       UPAR/Ly6 1.
FT   DOMAIN      140    222       UPAR/Ly6 2.
FT   LIPID       326    326       GPI-anchor amidated cysteine.
FT                                {ECO:0000255}.
FT   CARBOHYD    118    118       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    163    163       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    176    176       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    183    183       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   346 AA;  35971 MW;  97FF9B4A554934FF CRC64;
     MDPARKAGAQ AMIWTAGWLL LLLLRGGAQA LECYSCVQKA DDGCSPNKMK TVKCAPGVDV
     CTEAVGAVET IHGQFSLAVR GCGSGLPGKN DRGLDLHGLL AFIQLQQCAQ DRCNAKLNLT
     SRALDPAGNE SAYPPNGVEC YSCVGLSREA CQGTSPPVVS CYNASDHVYK GCFDGNVTLT
     AANVTVSLPV RGCVQDEFCT RDGVTGPGFT LSGSCCQGSR CNSDLRNKTY FSPRIPPLVR
     LPPPEPTTVA STTSVTTSTS APVRPTSTTK PMPAPTSQTP RQGVEHEASR DEEPRLTGGA
     AGHQDRSNSG QYPAKGGPQQ PHNKGCVAPT AGLAALLLAV AAGVLL
//