ID   NXPH4_HUMAN             Reviewed;         308 AA.
AC   O95158; A8K4I4; Q7Z6L3; Q8N462;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 3.
DT   13-FEB-2019, entry version 141.
DE   RecName: Full=Neurexophilin-4;
DE   Flags: Precursor;
GN   Name=NXPH4; Synonyms=NPH4; ORFNames=UNQ1928/PRO4403;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 225-308.
RX   PubMed=9570794;
RA   Missler M., Suedhof T.C.;
RT   "Neurexophilins form a conserved family of neuropeptide-like
RT   glycoproteins.";
RL   J. Neurosci. 18:3630-3638(1998).
CC   -!- FUNCTION: May be signaling molecules that resemble neuropeptides
CC       and that act by binding to alpha-neurexins and possibly other
CC       receptors. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain, spleen, and testis.
CC   -!- PTM: May be proteolytically processed at the boundary between the
CC       N-terminal non-conserved and the central conserved domain in
CC       neuron-like cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR   EMBL; AY358614; AAQ88977.1; -; mRNA.
DR   EMBL; AK290949; BAF83638.1; -; mRNA.
DR   EMBL; BC036679; AAH36679.1; -; mRNA.
DR   EMBL; BC053581; AAH53581.1; -; mRNA.
DR   EMBL; AF043469; AAD02282.1; -; mRNA.
DR   CCDS; CCDS8933.1; -.
DR   RefSeq; NP_009155.1; NM_007224.3.
DR   UniGene; Hs.745023; -.
DR   ProteinModelPortal; O95158; -.
DR   SMR; O95158; -.
DR   BioGrid; 116408; 11.
DR   STRING; 9606.ENSP00000333593; -.
DR   PhosphoSitePlus; O95158; -.
DR   BioMuta; NXPH4; -.
DR   MaxQB; O95158; -.
DR   PaxDb; O95158; -.
DR   PeptideAtlas; O95158; -.
DR   PRIDE; O95158; -.
DR   ProteomicsDB; 50675; -.
DR   DNASU; 11247; -.
DR   Ensembl; ENST00000349394; ENSP00000333593; ENSG00000182379.
DR   GeneID; 11247; -.
DR   KEGG; hsa:11247; -.
DR   UCSC; uc010srf.2; human.
DR   CTD; 11247; -.
DR   EuPathDB; HostDB:ENSG00000182379.9; -.
DR   GeneCards; NXPH4; -.
DR   HGNC; HGNC:8078; NXPH4.
DR   MIM; 604637; gene.
DR   neXtProt; NX_O95158; -.
DR   OpenTargets; ENSG00000182379; -.
DR   PharmGKB; PA31866; -.
DR   eggNOG; ENOG410IHZT; Eukaryota.
DR   eggNOG; ENOG4111F7U; LUCA.
DR   GeneTree; ENSGT00940000161717; -.
DR   HOGENOM; HOG000261694; -.
DR   HOVERGEN; HBG052706; -.
DR   InParanoid; O95158; -.
DR   OMA; SKPCLYD; -.
DR   OrthoDB; 1030335at2759; -.
DR   PhylomeDB; O95158; -.
DR   TreeFam; TF333047; -.
DR   ChiTaRS; NXPH4; human.
DR   GenomeRNAi; 11247; -.
DR   PRO; PR:O95158; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000182379; Expressed in 99 organ(s), highest expression level in cerebellar hemisphere.
DR   ExpressionAtlas; O95158; baseline and differential.
DR   Genevisible; O95158; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
DR   InterPro; IPR010450; Nxph.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   PANTHER; PTHR17103; PTHR17103; 1.
DR   Pfam; PF06312; Neurexophilin; 2.
DR   PIRSF; PIRSF038019; Neurexophilin; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    308       Neurexophilin-4.
FT                                /FTId=PRO_0000020068.
FT   REGION       24     84       II.
FT   REGION       85    163       III.
FT   REGION      164    224       IV (linker domain).
FT   REGION      225    308       V (Cys-rich).
FT   CARBOHYD     72     72       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    133    133       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    143    143       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    149    149       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT     56     56       S -> T (in Ref. 3; AAH36679).
FT                                {ECO:0000305}.
FT   CONFLICT    226    227       KE -> RG (in Ref. 4; AAD02282).
FT                                {ECO:0000305}.
FT   CONFLICT    296    296       P -> Q (in Ref. 3; AAH36679).
FT                                {ECO:0000305}.
SQ   SEQUENCE   308 AA;  33065 MW;  C18780A422AF6F6D CRC64;
     MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL PEPRSSDGLG
     VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA RAKKIFGWGD FYFRVHTLKF
     SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL
     ALEGVLPGLG PPLGMAAAAA GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT
     NRARKHRPCL YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF
     QSEHPYFG
//