ID   NXPH3_HUMAN             Reviewed;         252 AA.
AC   O95157; Q8NDC3; Q8TBF6; Q9ULR1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2002, sequence version 3.
DT   13-FEB-2019, entry version 138.
DE   RecName: Full=Neurexophilin-3;
DE   Flags: Precursor;
GN   Name=NXPH3; Synonyms=KIAA1159, NPH3; ORFNames=UNQ687/PRO1327;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-252.
RC   TISSUE=Brain;
RX   PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA   Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT   "Characterization of cDNA clones selected by the GeneMark analysis
RT   from size-fractionated cDNA libraries from human brain.";
RL   DNA Res. 6:329-336(1999).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 80-252.
RX   PubMed=9570794;
RA   Missler M., Suedhof T.C.;
RT   "Neurexophilins form a conserved family of neuropeptide-like
RT   glycoproteins.";
RL   J. Neurosci. 18:3630-3638(1998).
RN   [7]
RP   PROTEIN SEQUENCE OF 23-37.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: May be signaling molecules that resemble neuropeptides.
CC       Ligand for alpha-neurexins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highest level in brain.
CC   -!- PTM: May be proteolytically processed at the boundary between the
CC       N-terminal non-conserved and the central conserved domain in
CC       neuron-like cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR   EMBL; AY358526; AAQ88890.1; -; mRNA.
DR   EMBL; AL834282; CAD38956.2; -; mRNA.
DR   EMBL; CH471109; EAW94676.1; -; Genomic_DNA.
DR   EMBL; BC022541; AAH22541.1; -; mRNA.
DR   EMBL; AB032985; BAA86473.1; -; mRNA.
DR   EMBL; AF043468; AAD02281.1; -; mRNA.
DR   CCDS; CCDS11550.1; -.
DR   RefSeq; NP_009156.2; NM_007225.2.
DR   UniGene; Hs.55069; -.
DR   ProteinModelPortal; O95157; -.
DR   SMR; O95157; -.
DR   BioGrid; 116409; 9.
DR   IntAct; O95157; 5.
DR   MINT; O95157; -.
DR   STRING; 9606.ENSP00000329295; -.
DR   iPTMnet; O95157; -.
DR   PhosphoSitePlus; O95157; -.
DR   BioMuta; NXPH3; -.
DR   jPOST; O95157; -.
DR   PaxDb; O95157; -.
DR   PeptideAtlas; O95157; -.
DR   PRIDE; O95157; -.
DR   ProteomicsDB; 50674; -.
DR   Ensembl; ENST00000328741; ENSP00000329295; ENSG00000182575.
DR   GeneID; 11248; -.
DR   KEGG; hsa:11248; -.
DR   UCSC; uc002ipa.4; human.
DR   CTD; 11248; -.
DR   EuPathDB; HostDB:ENSG00000182575.7; -.
DR   GeneCards; NXPH3; -.
DR   HGNC; HGNC:8077; NXPH3.
DR   MIM; 604636; gene.
DR   neXtProt; NX_O95157; -.
DR   OpenTargets; ENSG00000182575; -.
DR   PharmGKB; PA31865; -.
DR   eggNOG; ENOG410IK4V; Eukaryota.
DR   eggNOG; ENOG410Y975; LUCA.
DR   GeneTree; ENSGT00940000158709; -.
DR   HOGENOM; HOG000261694; -.
DR   HOVERGEN; HBG052706; -.
DR   InParanoid; O95157; -.
DR   KO; K16658; -.
DR   OrthoDB; 1098941at2759; -.
DR   PhylomeDB; O95157; -.
DR   TreeFam; TF333047; -.
DR   GeneWiki; NXPH3; -.
DR   GenomeRNAi; 11248; -.
DR   PRO; PR:O95157; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000182575; Expressed in 191 organ(s), highest expression level in thoracic aorta.
DR   ExpressionAtlas; O95157; baseline and differential.
DR   Genevisible; O95157; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
DR   InterPro; IPR010450; Nxph.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   PANTHER; PTHR17103; PTHR17103; 1.
DR   Pfam; PF06312; Neurexophilin; 1.
DR   PIRSF; PIRSF038019; Neurexophilin; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     22       {ECO:0000269|PubMed:15340161}.
FT   CHAIN        23    252       Neurexophilin-3.
FT                                /FTId=PRO_0000020065.
FT   REGION       23     75       II.
FT   REGION       76    157       III.
FT   REGION      158    166       IV (linker domain).
FT   REGION      167    252       V (Cys-rich).
FT   CARBOHYD     62     62       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    127    127       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    137    137       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    143    143       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT    178    178       E -> G (in Ref. 4; AAH22541).
FT                                {ECO:0000305}.
SQ   SEQUENCE   252 AA;  28127 MW;  74D2B3D5A89D221F CRC64;
     MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPERDDHEG QPRPRVPRKR GHISPKSRPM
     ANSTLLGLLA PPGEAWGILG QPPNRPNHSP PPSAKVKKIF GWGDFYSNIK TVALNLLVTG
     KIVDHGNGTF SVHFQHNATG QGNISISLVP PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE
     KVERGRRTSL CTHDPAKICS RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY
     NYHSDTPYYP SG
//