ID   NXPH2_HUMAN             Reviewed;         264 AA.
AC   O95156; B7WP24; Q494R1; Q75QC3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   13-FEB-2019, entry version 122.
DE   RecName: Full=Neurexophilin-2;
DE   Flags: Precursor;
GN   Name=NXPH2; Synonyms=NPH2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neuroblastoma;
RA   Kawasaki A., Ohira M., Miyazaki K., Nakagawara A.;
RT   "Cloning of a full-length human neurexophilin2 gene.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-264.
RX   PubMed=9570794;
RA   Missler M., Suedhof T.C.;
RT   "Neurexophilins form a conserved family of neuropeptide-like
RT   glycoproteins.";
RL   J. Neurosci. 18:3630-3638(1998).
CC   -!- FUNCTION: May be signaling molecules that resemble neuropeptides
CC       and that act by binding to alpha-neurexins and possibly other
CC       receptors. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain and kidney.
CC   -!- PTM: May be proteolytically processed at the boundary between the
CC       N-terminal non-conserved and the central conserved domain in
CC       neuron-like cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR   EMBL; AB162675; BAD11132.1; -; mRNA.
DR   EMBL; AC092620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC110421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC101462; AAI01463.1; -; mRNA.
DR   EMBL; BC101463; AAI01464.1; -; mRNA.
DR   EMBL; BC104741; AAI04742.1; -; mRNA.
DR   EMBL; AF043467; AAD02280.1; -; mRNA.
DR   CCDS; CCDS46421.1; -.
DR   RefSeq; NP_009157.1; NM_007226.2.
DR   UniGene; Hs.435019; -.
DR   ProteinModelPortal; O95156; -.
DR   BioGrid; 116410; 20.
DR   STRING; 9606.ENSP00000272641; -.
DR   iPTMnet; O95156; -.
DR   PhosphoSitePlus; O95156; -.
DR   BioMuta; NXPH2; -.
DR   PaxDb; O95156; -.
DR   PeptideAtlas; O95156; -.
DR   PRIDE; O95156; -.
DR   ProteomicsDB; 50673; -.
DR   Ensembl; ENST00000272641; ENSP00000272641; ENSG00000144227.
DR   GeneID; 11249; -.
DR   KEGG; hsa:11249; -.
DR   UCSC; uc002tvi.4; human.
DR   CTD; 11249; -.
DR   DisGeNET; 11249; -.
DR   EuPathDB; HostDB:ENSG00000144227.4; -.
DR   GeneCards; NXPH2; -.
DR   HGNC; HGNC:8076; NXPH2.
DR   HPA; HPA034759; -.
DR   MIM; 604635; gene.
DR   neXtProt; NX_O95156; -.
DR   OpenTargets; ENSG00000144227; -.
DR   PharmGKB; PA31864; -.
DR   eggNOG; ENOG410INCH; Eukaryota.
DR   eggNOG; ENOG410ZJUS; LUCA.
DR   GeneTree; ENSGT00940000153959; -.
DR   HOGENOM; HOG000261694; -.
DR   HOVERGEN; HBG052706; -.
DR   InParanoid; O95156; -.
DR   KO; K16657; -.
DR   OMA; VPKPGHL; -.
DR   OrthoDB; 971662at2759; -.
DR   PhylomeDB; O95156; -.
DR   TreeFam; TF333047; -.
DR   ChiTaRS; NXPH2; human.
DR   GenomeRNAi; 11249; -.
DR   PRO; PR:O95156; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000144227; Expressed in 57 organ(s), highest expression level in heart.
DR   Genevisible; O95156; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
DR   InterPro; IPR010450; Nxph.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   PANTHER; PTHR17103; PTHR17103; 1.
DR   Pfam; PF06312; Neurexophilin; 1.
DR   PIRSF; PIRSF038019; Neurexophilin; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    264       Neurexophilin-2.
FT                                /FTId=PRO_0000020063.
FT   REGION       23     90       II.
FT   REGION       91    169       III.
FT   REGION      170    178       IV (linker domain).
FT   REGION      179    264       V (Cys-rich).
FT   CARBOHYD     86     86       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    139    139       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    149    149       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    155    155       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT      7     12       PLVVVP -> ARVLVT (in Ref. 4; AAD02280).
FT                                {ECO:0000305}.
SQ   SEQUENCE   264 AA;  29938 MW;  E793B5AD69FD0E71 CRC64;
     MRLRPLPLVV VPGLLQLLFC DSKEVVHATE GLDWEDKDAP GTLVGNVVHS RIISPLRLFV
     KQSPVPKPGP MAYADSMENF WDWLANITEI QEPLARTKRR PIVKTGKFKK MFGWGDFHSN
     IKTVKLNLLI TGKIVDHGNG TFSVYFRHNS TGLGNVSVSL VPPSKVVEFE VSPQSTLETK
     ESKSFNCRIE YEKTDRAKKT ALCNFDPSKI CYQEQTQSHV SWLCSKPFKV ICIYIAFYSV
     DYKLVQKVCP DYNYHSETPY LSSG
//