ID   PRS23_HUMAN             Reviewed;         383 AA.
AC   O95084; B2RDJ1; B4E2J3; Q6IBI0;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   13-FEB-2019, entry version 161.
DE   RecName: Full=Serine protease 23;
DE            EC=3.4.21.-;
DE   AltName: Full=Putative secreted protein Zsig13;
DE   Flags: Precursor;
GN   Name=PRSS23; Synonyms=ZSIG13; ORFNames=UNQ270/PRO307;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Umbilical vein;
RA   Li X., Tedder T.F.;
RT   "A novel serine protease from human umbilical vein endothelial
RT   cells.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Sheppard P., Blumberg H., Jelinek L., Foster D., O'Hara P.;
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Uterus;
RX   PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA   Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA   Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA   Wambutt R., Korn B., Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and
RT   analysis of 500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Placenta, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   PHOSPHORYLATION AT SER-109.
RX   PubMed=26091039; DOI=10.1016/j.cell.2015.05.028;
RA   Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J.,
RA   Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N.,
RA   Pinna L.A., Pagliarini D.J., Dixon J.E.;
RT   "A single kinase generates the majority of the secreted
RT   phosphoproteome.";
RL   Cell 161:1619-1632(2015).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O95084-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O95084-2; Sequence=VSP_056628;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000305}.
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DR   EMBL; AF015287; AAD01553.1; -; mRNA.
DR   EMBL; AF193611; AAF07186.1; -; mRNA.
DR   EMBL; AL136914; CAB66848.1; -; mRNA.
DR   EMBL; AY359033; AAQ89392.1; -; mRNA.
DR   EMBL; CR456824; CAG33105.1; -; mRNA.
DR   EMBL; AK304301; BAG65155.1; -; mRNA.
DR   EMBL; AK315562; BAG37938.1; -; mRNA.
DR   EMBL; AP000654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471076; EAW75145.1; -; Genomic_DNA.
DR   EMBL; BC001278; AAH01278.1; -; mRNA.
DR   CCDS; CCDS8278.1; -. [O95084-1]
DR   RefSeq; NP_001280107.1; NM_001293178.1.
DR   RefSeq; NP_001280108.1; NM_001293179.1. [O95084-1]
DR   RefSeq; NP_001280109.1; NM_001293180.1. [O95084-1]
DR   RefSeq; NP_009104.2; NM_007173.5. [O95084-1]
DR   UniGene; Hs.25338; -.
DR   UniGene; Hs.729257; -.
DR   ProteinModelPortal; O95084; -.
DR   BioGrid; 116279; 45.
DR   IntAct; O95084; 38.
DR   STRING; 9606.ENSP00000280258; -.
DR   MEROPS; S01.309; -.
DR   GlyConnect; 1736; -.
DR   iPTMnet; O95084; -.
DR   PhosphoSitePlus; O95084; -.
DR   BioMuta; PRSS23; -.
DR   EPD; O95084; -.
DR   jPOST; O95084; -.
DR   MaxQB; O95084; -.
DR   PaxDb; O95084; -.
DR   PeptideAtlas; O95084; -.
DR   PRIDE; O95084; -.
DR   ProteomicsDB; 50649; -.
DR   TopDownProteomics; O95084-1; -. [O95084-1]
DR   DNASU; 11098; -.
DR   Ensembl; ENST00000280258; ENSP00000280258; ENSG00000150687. [O95084-1]
DR   GeneID; 11098; -.
DR   KEGG; hsa:11098; -.
DR   UCSC; uc001pcb.4; human. [O95084-1]
DR   CTD; 11098; -.
DR   DisGeNET; 11098; -.
DR   EuPathDB; HostDB:ENSG00000150687.11; -.
DR   GeneCards; PRSS23; -.
DR   HGNC; HGNC:14370; PRSS23.
DR   HPA; HPA030591; -.
DR   neXtProt; NX_O95084; -.
DR   OpenTargets; ENSG00000150687; -.
DR   PharmGKB; PA134952846; -.
DR   eggNOG; ENOG410IF0G; Eukaryota.
DR   eggNOG; ENOG410ZRQ7; LUCA.
DR   GeneTree; ENSGT00390000000155; -.
DR   HOGENOM; HOG000059661; -.
DR   HOVERGEN; HBG053702; -.
DR   InParanoid; O95084; -.
DR   KO; K09627; -.
DR   OMA; NANDIGM; -.
DR   OrthoDB; 1245017at2759; -.
DR   PhylomeDB; O95084; -.
DR   TreeFam; TF329011; -.
DR   Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-HSA-8957275; Post-translational protein phosphorylation.
DR   ChiTaRS; PRSS23; human.
DR   GeneWiki; PRSS23; -.
DR   GenomeRNAi; 11098; -.
DR   PRO; PR:O95084; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000150687; Expressed in 233 organ(s), highest expression level in nasal cavity epithelium.
DR   ExpressionAtlas; O95084; baseline and differential.
DR   Genevisible; O95084; HS.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
DR   GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
KW   Hydrolase; Phosphoprotein; Protease; Reference proteome; Secreted;
KW   Serine protease; Signal.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    383       Serine protease 23.
FT                                /FTId=PRO_0000027847.
FT   ACT_SITE    175    175       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10078}.
FT   ACT_SITE    240    240       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10078}.
FT   ACT_SITE    316    316       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10078}.
FT   MOD_RES     109    109       Phosphoserine; by FAM20C.
FT                                {ECO:0000269|PubMed:26091039}.
FT   CARBOHYD     93     93       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    207    207       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    160    176       {ECO:0000250}.
FT   VAR_SEQ      49     80       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_056628.
SQ   SEQUENCE   383 AA;  43001 MW;  46EB6C11ABFD5E8F CRC64;
     MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK PDFGAEAKLE
     VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ VGIYILSSSG DGAQHRDSGS
     SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF STSVKLSTGC TGTLVAEKHV LTAAHCIHDG
     KTYVKGTQKL RVGFLKPKFK DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND
     IGMDYDYALL ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE
     TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG SPQDFNVAVR
     ITPLKYAQIC YWIKGNYLDC REG
//