ID SLIK5_HUMAN Reviewed; 958 AA. AC O94991; B3KNB8; B4DSH5; Q5VT81; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 13-APR-2004, sequence version 2. DT 13-FEB-2019, entry version 157. DE RecName: Full=SLIT and NTRK-like protein 5; DE AltName: Full=Leucine-rich repeat-containing protein 11; DE Flags: Precursor; GN Name=SLITRK5; Synonyms=KIAA0918, LRRC11; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain; RX PubMed=10048485; DOI=10.1093/dnares/5.6.355; RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., RA Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XII. RT The complete sequences of 100 new cDNA clones from brain which code RT for large proteins in vitro."; RL DNA Res. 5:355-364(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP IDENTIFICATION, AND TISSUE SPECIFICITY. RC TISSUE=Brain, and Brain tumor; RX PubMed=14557068; DOI=10.1016/S0378-1119(03)00715-7; RA Aruga J., Yokota N., Mikoshiba K.; RT "Human SLITRK family genes: genomic organization and expression RT profiling in normal brain and brain tumor tissue."; RL Gene 315:87-94(2003). CC -!- FUNCTION: Suppresses neurite outgrowth. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I CC membrane protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=O94991-1; Sequence=Displayed; CC Name=2; CC IsoId=O94991-2; Sequence=VSP_056676, VSP_056677; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Expressed predominantly in the cerebral cortex CC of the brain but also at low levels in the spinal cord and CC medulla. {ECO:0000269|PubMed:14557068}. CC -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAA74941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB020725; BAA74941.1; ALT_INIT; mRNA. DR EMBL; AK024251; BAG51280.1; -; mRNA. DR EMBL; AK299744; BAG61637.1; -; mRNA. DR EMBL; AL603883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471085; EAX08917.1; -; Genomic_DNA. DR EMBL; BC098106; AAH98106.1; -; mRNA. DR EMBL; BC103509; AAI03510.1; -; mRNA. DR CCDS; CCDS9465.1; -. [O94991-1] DR RefSeq; NP_056382.1; NM_015567.1. [O94991-1] DR RefSeq; XP_005254095.1; XM_005254038.4. [O94991-1] DR RefSeq; XP_005254096.1; XM_005254039.2. [O94991-1] DR UniGene; Hs.591208; -. DR ProteinModelPortal; O94991; -. DR SMR; O94991; -. DR BioGrid; 117513; 5. DR IntAct; O94991; 1. DR STRING; 9606.ENSP00000366283; -. DR iPTMnet; O94991; -. DR PhosphoSitePlus; O94991; -. DR BioMuta; SLITRK5; -. DR EPD; O94991; -. DR jPOST; O94991; -. DR MaxQB; O94991; -. DR PaxDb; O94991; -. DR PeptideAtlas; O94991; -. DR PRIDE; O94991; -. DR ProteomicsDB; 50619; -. DR Ensembl; ENST00000325089; ENSP00000366283; ENSG00000165300. [O94991-1] DR GeneID; 26050; -. DR KEGG; hsa:26050; -. DR UCSC; uc001vln.4; human. [O94991-1] DR CTD; 26050; -. DR DisGeNET; 26050; -. DR EuPathDB; HostDB:ENSG00000165300.7; -. DR GeneCards; SLITRK5; -. DR HGNC; HGNC:20295; SLITRK5. DR HPA; HPA013843; -. DR MIM; 609680; gene. DR neXtProt; NX_O94991; -. DR OpenTargets; ENSG00000165300; -. DR PharmGKB; PA134885524; -. DR eggNOG; ENOG410IGN5; Eukaryota. DR eggNOG; ENOG4111D19; LUCA. DR GeneTree; ENSGT00940000158453; -. DR HOGENOM; HOG000290667; -. DR HOVERGEN; HBG056407; -. DR InParanoid; O94991; -. DR OMA; CPRKLIS; -. DR OrthoDB; 217854at2759; -. DR PhylomeDB; O94991; -. DR TreeFam; TF326378; -. DR Reactome; R-HSA-388844; Receptor-type tyrosine-protein phosphatases. DR GeneWiki; SLITRK5; -. DR GenomeRNAi; 26050; -. DR PRO; PR:O94991; -. DR Proteomes; UP000005640; Chromosome 13. DR Bgee; ENSG00000165300; Expressed in 136 organ(s), highest expression level in neocortex. DR Genevisible; O94991; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0043235; C:receptor complex; IDA:MGI. DR GO; GO:0030534; P:adult behavior; IEA:Ensembl. DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central. DR GO; GO:0072358; P:cardiovascular system development; IEA:Ensembl. DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl. DR GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl. DR GO; GO:0007625; P:grooming behavior; IEA:Ensembl. DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl. DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl. DR GO; GO:0043588; P:skin development; IEA:Ensembl. DR GO; GO:0021756; P:striatum development; IEA:Ensembl. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR Pfam; PF13855; LRR_8; 2. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00082; LRRCT; 2. DR PROSITE; PS51450; LRR; 11. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Glycoprotein; KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 40 {ECO:0000255}. FT CHAIN 41 958 SLIT and NTRK-like protein 5. FT /FTId=PRO_0000032681. FT TOPO_DOM 41 664 Extracellular. {ECO:0000255}. FT TRANSMEM 665 685 Helical. {ECO:0000255}. FT TOPO_DOM 686 958 Cytoplasmic. {ECO:0000255}. FT REPEAT 82 103 LRR 1. FT REPEAT 106 127 LRR 2. FT REPEAT 130 151 LRR 3. FT REPEAT 154 175 LRR 4. FT REPEAT 178 199 LRR 5. FT REPEAT 201 222 LRR 6. FT DOMAIN 235 286 LRRCT 1. FT DOMAIN 365 407 LRRNT. FT REPEAT 410 431 LRR 7. FT REPEAT 434 455 LRR 8. FT REPEAT 458 479 LRR 9. FT REPEAT 482 503 LRR 10. FT REPEAT 506 527 LRR 11. FT REPEAT 529 550 LRR 12. FT DOMAIN 563 614 LRRCT 2. FT CARBOHYD 103 103 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 644 644 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT VAR_SEQ 1 31 MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVT -> MGAGKH FT REGGGGDPTSLNGCADLIQRRTEIS (in isoform 2). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_056676. FT VAR_SEQ 32 272 Missing (in isoform 2). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_056677. SQ SEQUENCE 958 AA; 107486 MW; 69E71DC1EE3C568B CRC64; MHTCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN ACPCEEKDGI LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE FVNYTGASIL HLGSNVIQDI ETGAFHGLRG LRRLHLNNNK LELLRDDTFL GLENLEYLQV DYNYISVIEP NAFGKLHLLQ VLILNDNLLS SLPNNLFRFV PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS CELISLKDWL DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS KDLGYSNYGP SIAYQTKSPV PLECPTACSC NLQISDLGLN VNCQERKIES IAELQPKPYN PKKMYLTENY IAVVRRTDFL EATGLDLLHL GNNRISMIQD RAFGDLTNLR RLYLNGNRIE RLSPELFYGL QSLQYLFLQY NLIREIQSGT FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF TSLPVSGVLD QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKVGVLVDEV ICKAPKKFAE TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA SLGAGGGASS VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT STNNSDVSSF NMQYSVYGGG GGTGGHPHAH VHHRGPALPK VKTPAGHVYE YIPHPLGHMC KNPIYRSREG NSVEDYKDLH ELKVTYSSNH HLQQQQQPPP PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP REDLLSPVQD ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE KQTTFSQF //