ID   SLIK3_HUMAN             Reviewed;         977 AA.
AC   O94933; Q1RMY6;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   13-FEB-2019, entry version 146.
DE   RecName: Full=SLIT and NTRK-like protein 3;
DE   Flags: Precursor;
GN   Name=SLITRK3; Synonyms=KIAA0848;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M.,
RA   Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 5:355-364(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain, and Brain tumor;
RX   PubMed=14557068; DOI=10.1016/S0378-1119(03)00715-7;
RA   Aruga J., Yokota N., Mikoshiba K.;
RT   "Human SLITRK family genes: genomic organization and expression
RT   profiling in normal brain and brain tumor tissue.";
RL   Gene 315:87-94(2003).
CC   -!- FUNCTION: Suppresses neurite outgrowth. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the occipital lobe of the
CC       cerebral cortex of the brain. Expressed at higher levels in some
CC       astrocytic brain tumors such as astrocytomas, oligodendrogliomas,
CC       glioblastomas, gangliogliomas and primitive neuroectodermal
CC       tumors. {ECO:0000269|PubMed:14557068}.
CC   -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA74871.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AB020655; BAA74871.2; ALT_INIT; mRNA.
DR   EMBL; AK290024; BAF82713.1; -; mRNA.
DR   EMBL; CH471052; EAW78599.1; -; Genomic_DNA.
DR   EMBL; BC114621; AAI14622.1; -; mRNA.
DR   CCDS; CCDS3197.1; -.
DR   RefSeq; NP_001305739.1; NM_001318810.1.
DR   RefSeq; NP_001305740.1; NM_001318811.1.
DR   RefSeq; NP_055741.2; NM_014926.3.
DR   UniGene; Hs.101745; -.
DR   ProteinModelPortal; O94933; -.
DR   SMR; O94933; -.
DR   BioGrid; 116533; 4.
DR   IntAct; O94933; 3.
DR   STRING; 9606.ENSP00000241274; -.
DR   iPTMnet; O94933; -.
DR   PhosphoSitePlus; O94933; -.
DR   BioMuta; SLITRK3; -.
DR   EPD; O94933; -.
DR   jPOST; O94933; -.
DR   PaxDb; O94933; -.
DR   PeptideAtlas; O94933; -.
DR   PRIDE; O94933; -.
DR   ProteomicsDB; 50569; -.
DR   Ensembl; ENST00000241274; ENSP00000241274; ENSG00000121871.
DR   Ensembl; ENST00000475390; ENSP00000420091; ENSG00000121871.
DR   GeneID; 22865; -.
DR   KEGG; hsa:22865; -.
DR   UCSC; uc003fej.4; human.
DR   CTD; 22865; -.
DR   DisGeNET; 22865; -.
DR   EuPathDB; HostDB:ENSG00000121871.3; -.
DR   GeneCards; SLITRK3; -.
DR   H-InvDB; HIX0003827; -.
DR   HGNC; HGNC:23501; SLITRK3.
DR   HPA; HPA017636; -.
DR   HPA; HPA048042; -.
DR   MIM; 609679; gene.
DR   neXtProt; NX_O94933; -.
DR   OpenTargets; ENSG00000121871; -.
DR   PharmGKB; PA134958002; -.
DR   eggNOG; ENOG410JR1Z; Eukaryota.
DR   eggNOG; ENOG410Y1DK; LUCA.
DR   GeneTree; ENSGT00940000158681; -.
DR   HOGENOM; HOG000290667; -.
DR   HOVERGEN; HBG056407; -.
DR   InParanoid; O94933; -.
DR   OMA; NPIYKPR; -.
DR   OrthoDB; 217854at2759; -.
DR   PhylomeDB; O94933; -.
DR   TreeFam; TF351826; -.
DR   Reactome; R-HSA-388844; Receptor-type tyrosine-protein phosphatases.
DR   GenomeRNAi; 22865; -.
DR   PRO; PR:O94933; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000121871; Expressed in 98 organ(s), highest expression level in left uterine tube.
DR   ExpressionAtlas; O94933; baseline and differential.
DR   Genevisible; O94933; HS.
DR   GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR   GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR   GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IDA:SynGO.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR   GO; GO:1905606; P:regulation of presynapse assembly; IDA:SynGO.
DR   GO; GO:0099560; P:synaptic membrane adhesion; IDA:SynGO.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SMART; SM00082; LRRCT; 2.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Polymorphism; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27    977       SLIT and NTRK-like protein 3.
FT                                /FTId=PRO_0000032677.
FT   TOPO_DOM     29    654       Extracellular. {ECO:0000255}.
FT   TRANSMEM    655    675       Helical. {ECO:0000255}.
FT   TOPO_DOM    676    977       Cytoplasmic. {ECO:0000255}.
FT   REPEAT       78     99       LRR 1.
FT   REPEAT      102    123       LRR 2.
FT   REPEAT      126    147       LRR 3.
FT   REPEAT      150    171       LRR 4.
FT   REPEAT      174    195       LRR 5.
FT   REPEAT      197    218       LRR 6.
FT   DOMAIN      232    283       LRRCT 1.
FT   DOMAIN      364    406       LRRNT.
FT   REPEAT      409    430       LRR 7.
FT   REPEAT      433    454       LRR 8.
FT   REPEAT      457    478       LRR 9.
FT   REPEAT      481    502       LRR 10.
FT   REPEAT      505    526       LRR 11.
FT   REPEAT      528    549       LRR 12.
FT   DOMAIN      562    613       LRRCT 2.
FT   COMPBIAS    712    723       Poly-Gly.
FT   CARBOHYD     68     68       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    596    596       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VARIANT     605    605       I -> V (in dbSNP:rs3828419).
FT                                /FTId=VAR_027757.
FT   CONFLICT    940    940       G -> E (in Ref. 1; BAA74871).
FT                                {ECO:0000305}.
SQ   SEQUENCE   977 AA;  108934 MW;  66936B7E00008961 CRC64;
     MKPSIAEMLH RGRMLWIILL STIALGWTTP IPLIEDSEEI DEPCFDPCYC EVKESLFHIH
     CDSKGFTNIS QITEFWSRPF KLYLQRNSMR KLYTNSFLHL NNAVSINLGN NALQDIQTGA
     FNGLKILKRL YLHENKLDVF RNDTFLGLES LEYLQADYNV IKRIESGAFR NLSKLRVLIL
     NDNLIPMLPT NLFKAVSLTH LDLRGNRLKV LFYRGMLDHI GRSLMELQLE ENPWNCTCEI
     VQLKSWLERI PYTALVGDIT CETPFHFHGK DLREIRKTEL CPLLSDSEVE ASLGIPHSSS
     SKENAWPTKP SSMLSSVHFT ASSVEYKSSN KQPKPTKQPR TPRPPSTSQA LYPGPNQPPI
     APYQTRPPIP IICPTGCTCN LHINDLGLTV NCKERGFNNI SELLPRPLNA KKLYLSSNLI
     QKIYRSDFWN FSSLDLLHLG NNRISYVQDG AFINLPNLKS LFLNGNDIEK LTPGMFRGLQ
     SLHYLYFEFN VIREIQPAAF SLMPNLKLLF LNNNLLRTLP TDAFAGTSLA RLNLRKNYFL
     YLPVAGVLEH LNAIVQIDLN ENPWDCTCDL VPFKQWIETI SSVSVVGDVL CRSPENLTHR
     DVRTIELEVL CPEMLHVAPA GESPAQPGDS HLIGAPTSAS PYEFSPPGGP VPLSVLILSL
     LVLFFSAVFV AAGLFAYVLR RRRKKLPFRS KRQEGVDLTG IQMQCHRLFE DGGGGGGGSG
     GGGRPTLSSP EKAPPVGHVY EYIPHPVTQM CNNPIYKPRE EEEVAVSSAQ EAGSAERGGP
     GTQPPGMGEA LLGSEQFAET PKENHSNYRT LLEKEKEWAL AVSSSQLNTI VTVNHHHPHH
     PAVGGVSGVV GGTGGDLAGF RHHEKNGGVV LFPPGGGCGS GSMLLDRERP QPAPCTVGFV
     DCLYGTVPKL KELHVHPPGM QYPDLQQDAR LKETLLFSAG KGFTDHQTQK SDYLELRAKL
     QTKPDYLEVL EKTTYRF
//