ID   ENDD1_HUMAN             Reviewed;         500 AA.
AC   O94919; A8K6K8; Q6GQY5; Q8TAQ8;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 2.
DT   13-FEB-2019, entry version 138.
DE   RecName: Full=Endonuclease domain-containing 1 protein;
DE            EC=3.1.30.-;
DE   Flags: Precursor;
GN   Name=ENDOD1; Synonyms=KIAA0830;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M.,
RA   Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 5:355-364(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Platelet;
RX   PubMed=11921445;
RX   DOI=10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0;
RA   O'Neill E.E., Brock C.J., von Kriegsheim A.F., Pearce A.C., Dwek R.A.,
RA   Watson S.P., Hebestreit H.F.;
RT   "Towards complete analysis of the platelet proteome.";
RL   Proteomics 2:288-305(2002).
RN   [5]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-407, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA   Walther T.C., Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
CC   -!- FUNCTION: May act as a DNase and a RNase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DNA/RNA non-specific endonuclease
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA74853.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB020637; BAA74853.1; ALT_INIT; mRNA.
DR   EMBL; AK291673; BAF84362.1; -; mRNA.
DR   EMBL; BC026191; AAH26191.1; -; mRNA.
DR   EMBL; BC071171; AAH71171.1; -; mRNA.
DR   CCDS; CCDS41699.1; -.
DR   RefSeq; NP_055851.1; NM_015036.2.
DR   UniGene; Hs.167115; -.
DR   ProteinModelPortal; O94919; -.
DR   BioGrid; 116689; 29.
DR   IntAct; O94919; 11.
DR   MINT; O94919; -.
DR   iPTMnet; O94919; -.
DR   PhosphoSitePlus; O94919; -.
DR   SwissPalm; O94919; -.
DR   BioMuta; ENDOD1; -.
DR   OGP; O94919; -.
DR   EPD; O94919; -.
DR   jPOST; O94919; -.
DR   MaxQB; O94919; -.
DR   PaxDb; O94919; -.
DR   PeptideAtlas; O94919; -.
DR   PRIDE; O94919; -.
DR   ProteomicsDB; 50555; -.
DR   Ensembl; ENST00000278505; ENSP00000278505; ENSG00000149218.
DR   GeneID; 23052; -.
DR   KEGG; hsa:23052; -.
DR   UCSC; uc001pfh.4; human.
DR   CTD; 23052; -.
DR   EuPathDB; HostDB:ENSG00000149218.4; -.
DR   GeneCards; ENDOD1; -.
DR   HGNC; HGNC:29129; ENDOD1.
DR   HPA; HPA008932; -.
DR   HPA; HPA010517; -.
DR   neXtProt; NX_O94919; -.
DR   OpenTargets; ENSG00000149218; -.
DR   PharmGKB; PA143485454; -.
DR   eggNOG; ENOG410J1DZ; Eukaryota.
DR   eggNOG; ENOG4111RBI; LUCA.
DR   GeneTree; ENSGT00940000154825; -.
DR   HOGENOM; HOG000112371; -.
DR   HOVERGEN; HBG081477; -.
DR   InParanoid; O94919; -.
DR   KO; K15049; -.
DR   OMA; IPWKVLK; -.
DR   OrthoDB; 858590at2759; -.
DR   PhylomeDB; O94919; -.
DR   TreeFam; TF333322; -.
DR   Reactome; R-HSA-114608; Platelet degranulation.
DR   GenomeRNAi; 23052; -.
DR   PRO; PR:O94919; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149218; Expressed in 237 organ(s), highest expression level in corpus callosum.
DR   Genevisible; O94919; HS.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0002576; P:platelet degranulation; TAS:Reactome.
DR   InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR   InterPro; IPR039015; ENDOD1.
DR   InterPro; IPR020821; Extracellular_endonuc_su_A.
DR   PANTHER; PTHR21472; PTHR21472; 1.
DR   Pfam; PF01223; Endonuclease_NS; 1.
DR   SMART; SM00892; Endonuclease_NS; 1.
DR   SMART; SM00477; NUC; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Complete proteome; Endonuclease; Hydrolase; Nuclease;
KW   Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    500       Endonuclease domain-containing 1 protein.
FT                                /FTId=PRO_0000019924.
FT   MOD_RES     407    407       N6-acetyllysine.
FT                                {ECO:0000244|PubMed:19608861}.
FT   VARIANT     350    350       V -> M (in dbSNP:rs3740862).
FT                                /FTId=VAR_022044.
FT   VARIANT     446    446       G -> V (in dbSNP:rs3740861).
FT                                /FTId=VAR_022045.
FT   CONFLICT    113    113       N -> I (in Ref. 2; BAF84362).
FT                                {ECO:0000305}.
FT   CONFLICT    189    189       Q -> R (in Ref. 2; BAF84362).
FT                                {ECO:0000305}.
SQ   SEQUENCE   500 AA;  55017 MW;  5B62754FE2E9AD9C CRC64;
     MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD SHVKICQRAE
     GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ IDDPNSNLEE AINEAEAITS
     VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS SDVQVATFTL TNSAPMTQSF QERWYVNLHS
     LMDRALTPQC GSGEDLYILT GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT
     RDSDIIEDVM VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK
     SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV VAILKNIVYF
     LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK VLKVVAKVIR ALLRILCCLL
     KAICRVLSIP VRVLVDVATF PVYTMGAIPI VCKDIALGLG GTVSLLFDTA FGTLGGLFQV
     VFSVCKRIGY KVTFDNSGEL
//