ID LY6H_HUMAN Reviewed; 140 AA. AC O94772; B2RAD2; J3KQI0; Q6IAX0; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 13-FEB-2019, entry version 154. DE RecName: Full=Lymphocyte antigen 6H; DE Short=Ly-6H; DE Flags: Precursor; GN Name=LY6H; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Fetal brain; RX PubMed=9799603; DOI=10.1006/geno.1998.5462; RA Horie M., Okutomi K., Taniguchi Y., Ohbuchi Y., Suzuki M., RA Takahashi E.; RT "Isolation and characterization of a new member of the human Ly6 gene RT family (LY6H)."; RL Genomics 53:365-368(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Fetal brain; RA Li W.B., Gruber C., Jessee J., Polayes D.; RT "Full-length cDNA libraries and normalization."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Believed to act as a modulator of nicotinic CC acetylcholine receptors (nAChRs) activity. In vitro inhibits CC alpha-3:beta-4-containing nAChRs maximum response. May play a role CC in the intracellular trafficking of alpha-7-containing nAChRs and CC may inhibit their expression at the cell surface. Seems to inhibit CC alpha-7/CHRNA7 signaling in hippocampal neurons. CC {ECO:0000250|UniProtKB:F1LNW6, ECO:0000250|UniProtKB:Q9WUC3}. CC -!- SUBUNIT: Interacts with CHRNA4 and CHRNA7. CC {ECO:0000250|UniProtKB:Q9WUC3}. CC -!- INTERACTION: CC P26371:KRTAP5-9; NbExp=3; IntAct=EBI-724687, EBI-3958099; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, CC GPI-anchor {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=O94772-1; Sequence=Displayed; CC Name=2; CC IsoId=O94772-2; Sequence=VSP_053497; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Highly expressed in brain (cerebral cortex, CC amygdala, hippocampus and subthalamic nucleus) and in acute human CC leukemic cell line MOLT-3. Also found in lower levels in testis, CC pancreas, small intestine and colon. CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB012293; BAA34115.1; -; mRNA. DR EMBL; BX419752; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; CR457034; CAG33315.1; -; mRNA. DR EMBL; AK314139; BAG36829.1; -; mRNA. DR EMBL; AC083982; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471162; EAW82277.1; -; Genomic_DNA. DR EMBL; BC028894; AAH28894.1; -; mRNA. DR EMBL; BC030192; AAH30192.1; -; mRNA. DR CCDS; CCDS47926.1; -. [O94772-2] DR CCDS; CCDS6396.1; -. [O94772-1] DR RefSeq; NP_001123950.1; NM_001130478.1. [O94772-2] DR RefSeq; NP_001129127.1; NM_001135655.1. [O94772-2] DR RefSeq; NP_002338.3; NM_002347.4. [O94772-1] DR RefSeq; XP_016868903.1; XM_017013414.1. DR UniGene; Hs.159590; -. DR ProteinModelPortal; O94772; -. DR BioGrid; 110240; 1. DR IntAct; O94772; 3. DR STRING; 9606.ENSP00000342711; -. DR iPTMnet; O94772; -. DR PhosphoSitePlus; O94772; -. DR BioMuta; LY6H; -. DR jPOST; O94772; -. DR PaxDb; O94772; -. DR PeptideAtlas; O94772; -. DR PRIDE; O94772; -. DR ProteomicsDB; 50435; -. DR DNASU; 4062; -. DR Ensembl; ENST00000342752; ENSP00000342711; ENSG00000176956. [O94772-2] DR Ensembl; ENST00000414417; ENSP00000399485; ENSG00000176956. [O94772-2] DR Ensembl; ENST00000430474; ENSP00000409899; ENSG00000176956. [O94772-1] DR Ensembl; ENST00000610554; ENSP00000478470; ENSG00000274488. [O94772-1] DR Ensembl; ENST00000615409; ENSP00000480084; ENSG00000176956. [O94772-1] DR Ensembl; ENST00000615434; ENSP00000482094; ENSG00000274488. [O94772-2] DR Ensembl; ENST00000631670; ENSP00000487965; ENSG00000274488. [O94772-2] DR GeneID; 4062; -. DR KEGG; hsa:4062; -. DR UCSC; uc011lka.2; human. [O94772-1] DR CTD; 4062; -. DR EuPathDB; HostDB:ENSG00000176956.12; -. DR GeneCards; LY6H; -. DR HGNC; HGNC:6728; LY6H. DR MIM; 603625; gene. DR neXtProt; NX_O94772; -. DR OpenTargets; ENSG00000176956; -. DR PharmGKB; PA30492; -. DR eggNOG; ENOG410J4NS; Eukaryota. DR eggNOG; ENOG41117ZV; LUCA. DR GeneTree; ENSGT00940000154560; -. DR HOGENOM; HOG000059606; -. DR HOVERGEN; HBG006295; -. DR InParanoid; O94772; -. DR KO; K06846; -. DR OMA; AWSMLPA; -. DR OrthoDB; 1482771at2759; -. DR PhylomeDB; O94772; -. DR TreeFam; TF337757; -. DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR GenomeRNAi; 4062; -. DR PRO; PR:O94772; -. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000176956; Expressed in 124 organ(s), highest expression level in hypothalamus. DR Genevisible; O94772; HS. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central. DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central. DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central. DR GO; GO:0009887; P:animal organ morphogenesis; TAS:ProtInc. DR GO; GO:0007399; P:nervous system development; TAS:ProtInc. DR InterPro; IPR016054; LY6_UPA_recep-like. DR Pfam; PF00021; UPAR_LY6; 1. DR SMART; SM00134; LU; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; KW Reference proteome; Signal. FT SIGNAL 1 25 {ECO:0000255}. FT CHAIN 26 115 Lymphocyte antigen 6H. FT /FTId=PRO_0000036148. FT PROPEP 116 140 Removed in mature form. {ECO:0000255}. FT /FTId=PRO_0000036149. FT DOMAIN 26 91 UPAR/Ly6. FT LIPID 115 115 GPI-anchor amidated glycine. FT {ECO:0000255}. FT CARBOHYD 36 36 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 28 52 {ECO:0000250|UniProtKB:P0DP57, FT ECO:0000250|UniProtKB:P0DP58}. FT DISULFID 31 40 {ECO:0000250|UniProtKB:P0DP57, FT ECO:0000250|UniProtKB:P0DP58}. FT DISULFID 45 73 {ECO:0000250|UniProtKB:P0DP57, FT ECO:0000250|UniProtKB:P0DP58}. FT DISULFID 77 104 {ECO:0000250|UniProtKB:P0DP57, FT ECO:0000250|UniProtKB:P0DP58}. FT DISULFID 105 110 {ECO:0000250|UniProtKB:P0DP57, FT ECO:0000250|UniProtKB:P0DP58}. FT VAR_SEQ 1 1 M -> MLAPQRTRAPSPRAAPRPTRSM (in isoform FT 2). {ECO:0000303|Ref.2}. FT /FTId=VSP_053497. FT CONFLICT 4 4 A -> T (in Ref. 3; CAG33315). FT {ECO:0000305}. SQ SEQUENCE 140 AA; 14669 MW; A9274BFE89B6CBA3 CRC64; MLPAAMKGLG LALLAVLLCS APAHGLWCQD CTLTTNSSHC TPKQCQPSDT VCASVRITDP SSSRKDHSVN KMCASSCDFV KRHFFSDYLM GFINSGILKV DVDCCEKDLC NGAAGAGHSP WALAGGLLLS LGPALLWAGP //