ID ECM2_HUMAN Reviewed; 699 AA. AC O94769; B2R730; E2PU11; Q5T9F2; Q7Z3D0; DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 13-FEB-2019, entry version 155. DE RecName: Full=Extracellular matrix protein 2; DE AltName: Full=Matrix glycoprotein SC1/ECM2; DE Flags: Precursor; GN Name=ECM2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=9790758; DOI=10.1006/geno.1998.5455; RA Nishiu J., Tanaka T., Nakamura Y.; RT "Identification of a novel gene (ECM2) encoding a putative RT extracellular matrix protein expressed predominantly in adipose and RT female-specific tissues and its chromosomal localization to 9q22.3."; RL Genomics 52:378-381(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT RP PRO-56. RC TISSUE=Retina; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Promotes matrix assembly and cell adhesiveness. CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with numerous extracellular matrix proteins. CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=O94769-1; Sequence=Displayed; CC Name=2; CC IsoId=O94769-2; Sequence=VSP_039114, VSP_039115; CC -!- TISSUE SPECIFICITY: Expressed predominantly in adipose tissue as CC well as female-specific organs such as mammary gland, ovary, and CC uterus. CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP) CC family. SLRP class I subfamily. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAD97940.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB011792; BAA33958.1; -; mRNA. DR EMBL; AK312820; BAG35677.1; -; mRNA. DR EMBL; BX537976; CAD97940.1; ALT_INIT; mRNA. DR EMBL; AL137848; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL157827; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471089; EAW62824.1; -; Genomic_DNA. DR EMBL; BC107493; AAI07494.1; -; mRNA. DR CCDS; CCDS56578.1; -. [O94769-2] DR CCDS; CCDS6698.1; -. [O94769-1] DR RefSeq; NP_001184224.1; NM_001197295.1. DR RefSeq; NP_001184225.1; NM_001197296.1. [O94769-2] DR RefSeq; NP_001384.1; NM_001393.3. [O94769-1] DR UniGene; Hs.117060; -. DR ProteinModelPortal; O94769; -. DR IntAct; O94769; 1. DR STRING; 9606.ENSP00000344758; -. DR GlyConnect; 1229; -. DR iPTMnet; O94769; -. DR PhosphoSitePlus; O94769; -. DR BioMuta; ECM2; -. DR jPOST; O94769; -. DR PaxDb; O94769; -. DR PeptideAtlas; O94769; -. DR PRIDE; O94769; -. DR ProteomicsDB; 50433; -. DR ProteomicsDB; 50434; -. [O94769-2] DR DNASU; 1842; -. DR Ensembl; ENST00000344604; ENSP00000344758; ENSG00000106823. [O94769-1] DR Ensembl; ENST00000444490; ENSP00000393971; ENSG00000106823. [O94769-2] DR GeneID; 1842; -. DR KEGG; hsa:1842; -. DR UCSC; uc004asf.5; human. [O94769-1] DR CTD; 1842; -. DR DisGeNET; 1842; -. DR EuPathDB; HostDB:ENSG00000106823.12; -. DR GeneCards; ECM2; -. DR HGNC; HGNC:3154; ECM2. DR HPA; HPA035347; -. DR MIM; 603479; gene. DR neXtProt; NX_O94769; -. DR OpenTargets; ENSG00000106823; -. DR PharmGKB; PA27599; -. DR eggNOG; KOG0619; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00940000159941; -. DR HOGENOM; HOG000112319; -. DR HOVERGEN; HBG031529; -. DR InParanoid; O94769; -. DR KO; K08119; -. DR OMA; VWSPKPC; -. DR OrthoDB; 826997at2759; -. DR PhylomeDB; O94769; -. DR TreeFam; TF330031; -. DR GeneWiki; ECM2; -. DR GenomeRNAi; 1842; -. DR PRO; PR:O94769; -. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000106823; Expressed in 207 organ(s), highest expression level in adipose tissue. DR ExpressionAtlas; O94769; baseline and differential. DR Genevisible; O94769; HS. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl. DR GO; GO:0070052; F:collagen V binding; IBA:GO_Central. DR GO; GO:0008201; F:heparin binding; IBA:GO_Central. DR GO; GO:0005178; F:integrin binding; TAS:ProtInc. DR GO; GO:0007160; P:cell-matrix adhesion; TAS:ProtInc. DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central. DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IBA:GO_Central. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR025875; Leu-rich_rpt_4. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR001007; VWF_dom. DR Pfam; PF12799; LRR_4; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF00093; VWC; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00214; VWC; 1. DR PROSITE; PS51450; LRR; 12. DR PROSITE; PS01208; VWFC_1; 1. DR PROSITE; PS50184; VWFC_2; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Extracellular matrix; KW Glycoprotein; Leucine-rich repeat; Polymorphism; Reference proteome; KW Repeat; Secreted; Signal. FT SIGNAL 1 20 {ECO:0000255}. FT CHAIN 21 699 Extracellular matrix protein 2. FT /FTId=PRO_0000032731. FT DOMAIN 101 158 VWFC. {ECO:0000255|PROSITE- FT ProRule:PRU00220}. FT DOMAIN 307 344 LRRNT. FT REPEAT 368 388 LRR 1. FT REPEAT 394 415 LRR 2. FT REPEAT 416 436 LRR 3. FT REPEAT 439 459 LRR 4. FT REPEAT 465 484 LRR 5. FT REPEAT 486 507 LRR 6. FT REPEAT 510 530 LRR 7. FT REPEAT 536 557 LRR 8. FT REPEAT 558 578 LRR 9. FT REPEAT 582 602 LRR 10. FT REPEAT 609 630 LRR 11. FT REPEAT 632 653 LRR 12. FT REPEAT 661 684 LRR 13. FT MOTIF 294 296 Cell attachment site. {ECO:0000255}. FT COMPBIAS 270 281 Poly-Glu. FT CARBOHYD 378 378 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 449 449 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 506 506 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT VAR_SEQ 161 182 Missing (in isoform 2). FT {ECO:0000303|PubMed:17974005}. FT /FTId=VSP_039114. FT VAR_SEQ 645 699 NILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCI FT RSYSSIVLKPQNIK -> CVSDAVLETVTNRSDVAFPLW FT (in isoform 2). FT {ECO:0000303|PubMed:17974005}. FT /FTId=VSP_039115. FT VARIANT 56 56 Q -> P (in dbSNP:rs10120210). FT {ECO:0000269|PubMed:17974005}. FT /FTId=VAR_024646. FT VARIANT 109 109 T -> S (in dbSNP:rs35496743). FT /FTId=VAR_052010. FT VARIANT 204 204 R -> Q (in dbSNP:rs34758505). FT /FTId=VAR_052011. SQ SEQUENCE 699 AA; 79789 MW; E44E76A40A5C2742 CRC64; MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN RQLGIQQTTV FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK GHCLVKGITM YNKAVWSPEP CTTCLCSDGR VLCDETMCHP QRCPQTVIPE GECCPVCSAT VSYSLLSGIA LNDRNEFSGD SSEQREPTNL LHKQLPPPQV GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY SEGDSRGGDR KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL TGNSIASIPD EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM DGNNLIQIPS QLPSTLEELK VNENNLQAID EESLSDLNQL VTLELEGNNL SEANVNPLAF KPLKSLAYLR LGKNKFRIIP QGLPGSIEEL YLENNQIEEI TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI DLSYNKLYHV PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE ICNAEEDDDS NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK //