ID JTB_HUMAN Reviewed; 146 AA. AC O76095; O95442; Q6IB19; Q9P0Q4; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 13-FEB-2019, entry version 146. DE RecName: Full=Protein JTB; DE AltName: Full=Jumping translocation breakpoint protein; DE AltName: Full=Prostate androgen-regulated protein; DE Short=PAR protein; DE Flags: Precursor; GN Name=JTB; ORFNames=HSPC222; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), SUBCELLULAR RP LOCATION, AND TISSUE SPECIFICITY. RX PubMed=10321732; DOI=10.1038/sj.onc.1202510; RA Hatakeyama S., Osawa M., Omine M., Ishikawa F.; RT "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping RT translocation."; RL Oncogene 18:2085-2090(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Mammary cancer, and Prostatic carcinoma; RX PubMed=10762645; RA Platica O., Chen S., Ivan E., Lopingco M.C., Holland J.F., Platica M.; RT "PAR, a novel androgen regulated gene, ubiquitously expressed in RT normal and malignant cells."; RL Int. J. Oncol. 16:1055-1061(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain; RA Mei G., Yu W., Gibbs R.A.; RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Umbilical cord blood; RX PubMed=11042152; DOI=10.1101/gr.140200; RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.; RT "Cloning and functional analysis of cDNAs with open reading frames for RT 300 previously undefined genes expressed in CD34+ hematopoietic RT stem/progenitor cells."; RL Genome Res. 10:1546-1560(2000). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Tongue; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Cervix, Lung, Skin, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [11] RP TISSUE SPECIFICITY. RX PubMed=17369841; DOI=10.1038/sj.onc.1210423; RA Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K., RA Shibanuma M.; RT "Characterization of Jumping translocation breakpoint (JTB) gene RT product isolated as a TGF-beta1-inducible clone involved in regulation RT of mitochondrial function, cell growth and cell death."; RL Oncogene 26:5991-6001(2007). RN [12] RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AURKA; AURKB AND RP BIRC5, SUBUNIT, INDUCTION, AND TISSUE SPECIFICITY. RX PubMed=21225229; DOI=10.3892/ijo.2011.900; RA Platica M., Ionescu A., Ivan E., Holland J.F., Mandeli J., Platica O.; RT "PAR, a protein involved in the cell cycle, is functionally related to RT chromosomal passenger proteins."; RL Int. J. Oncol. 38:777-785(2011). RN [13] RP STRUCTURE BY NMR OF 47-104. RX PubMed=22079049; DOI=10.1016/j.jmb.2011.10.048; RA Rousseau F., Pan B., Fairbrother W.J., Bazan J.F., Lingel A.; RT "The structure of the extracellular domain of the jumping RT translocation breakpoint protein reveals a variation of the midkine RT fold."; RL J. Mol. Biol. 415:22-28(2012). CC -!- FUNCTION: Required for normal cytokinesis during mitosis. Plays a CC role in the regulation of cell proliferation. May be a component CC of the chromosomal passenger complex (CPC), a complex that acts as CC a key regulator of mitosis. The CPC complex has essential CC functions at the centromere in ensuring correct chromosome CC alignment and segregation and is required for chromatin-induced CC microtubule stabilization and spindle assembly. Increases AURKB CC activity. Inhibits apoptosis induced by TGFB1 (By similarity). CC Overexpression induces swelling of mitochondria and reduces CC mitochondrial membrane potential (By similarity). {ECO:0000250, CC ECO:0000269|PubMed:21225229}. CC -!- SUBUNIT: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a CC component of the CPC at least composed of BIRC5/survivin, CC CDCA8/borealin, INCENP and AURKB/Aurora-B. CC {ECO:0000269|PubMed:21225229}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I CC membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. CC Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, CC centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the CC centrosome and along spindle fibers during prophase and metaphase. CC Detected at the midbody during telophase. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=O76095-1; Sequence=Displayed; CC Name=2; CC IsoId=O76095-2; Sequence=VSP_041400; CC -!- TISSUE SPECIFICITY: Ubiquitous. Expressed in all normal human CC tissues studied but overexpressed or underexpressed in many of CC their malignant counterparts. {ECO:0000269|PubMed:10321732, CC ECO:0000269|PubMed:10762645, ECO:0000269|PubMed:17369841, CC ECO:0000269|PubMed:21225229}. CC -!- INDUCTION: Protein levels increase during the S phase of the cell CC cycle, are highest during G2 and mitosis, and decrease to low CC levels at G1. Levels are lowest at the transition from G1 to S CC phase. {ECO:0000269|PubMed:21225229}. CC -!- SIMILARITY: Belongs to the JTB family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB016492; BAA33735.1; -; Genomic_DNA. DR EMBL; AB016488; BAA33731.1; -; mRNA. DR EMBL; AB016493; BAA33736.1; -; Genomic_DNA. DR EMBL; AF115850; AAD09822.2; -; mRNA. DR EMBL; AF131797; AAD20045.1; -; mRNA. DR EMBL; AF151056; AAF36142.1; -; mRNA. DR EMBL; BT007285; AAP35949.1; -; mRNA. DR EMBL; CR456985; CAG33266.1; -; mRNA. DR EMBL; AK312106; BAG35042.1; -; mRNA. DR EMBL; AL358472; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471121; EAW53241.1; -; Genomic_DNA. DR EMBL; CH471121; EAW53242.1; -; Genomic_DNA. DR EMBL; CH471121; EAW53244.1; -; Genomic_DNA. DR EMBL; BC000499; AAH00499.1; -; mRNA. DR EMBL; BC000996; AAH00996.1; -; mRNA. DR EMBL; BC001363; AAH01363.1; -; mRNA. DR EMBL; BC001667; AAH01667.1; -; mRNA. DR EMBL; BC004239; AAH04239.1; -; mRNA. DR EMBL; BC019277; AAH19277.1; -; mRNA. DR CCDS; CCDS1057.1; -. [O76095-1] DR RefSeq; NP_006685.1; NM_006694.3. [O76095-1] DR UniGene; Hs.6396; -. DR PDB; 2KJX; NMR; -; A=47-104. DR PDBsum; 2KJX; -. DR ProteinModelPortal; O76095; -. DR SMR; O76095; -. DR BioGrid; 116105; 33. DR IntAct; O76095; 6. DR MINT; O76095; -. DR STRING; 9606.ENSP00000271843; -. DR iPTMnet; O76095; -. DR PhosphoSitePlus; O76095; -. DR BioMuta; JTB; -. DR EPD; O76095; -. DR jPOST; O76095; -. DR MaxQB; O76095; -. DR PaxDb; O76095; -. DR PeptideAtlas; O76095; -. DR PRIDE; O76095; -. DR ProteomicsDB; 50413; -. DR ProteomicsDB; 50414; -. [O76095-2] DR DNASU; 10899; -. DR Ensembl; ENST00000271843; ENSP00000271843; ENSG00000143543. [O76095-1] DR Ensembl; ENST00000356648; ENSP00000349069; ENSG00000143543. [O76095-2] DR Ensembl; ENST00000368589; ENSP00000357578; ENSG00000143543. [O76095-2] DR Ensembl; ENST00000428469; ENSP00000395250; ENSG00000143543. [O76095-2] DR GeneID; 10899; -. DR KEGG; hsa:10899; -. DR UCSC; uc001fds.4; human. [O76095-1] DR CTD; 10899; -. DR DisGeNET; 10899; -. DR EuPathDB; HostDB:ENSG00000143543.14; -. DR GeneCards; JTB; -. DR HGNC; HGNC:6201; JTB. DR HPA; HPA006514; -. DR MIM; 604671; gene. DR neXtProt; NX_O76095; -. DR OpenTargets; ENSG00000143543; -. DR PharmGKB; PA30003; -. DR eggNOG; KOG4084; Eukaryota. DR eggNOG; ENOG4111VSR; LUCA. DR GeneTree; ENSGT00390000016136; -. DR HOGENOM; HOG000294204; -. DR HOVERGEN; HBG000952; -. DR InParanoid; O76095; -. DR OMA; ECAPCSN; -. DR OrthoDB; 1375062at2759; -. DR PhylomeDB; O76095; -. DR TreeFam; TF316934; -. DR ChiTaRS; JTB; human. DR EvolutionaryTrace; O76095; -. DR GeneWiki; JTB_(gene); -. DR GenomeRNAi; 10899; -. DR PRO; PR:O76095; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000143543; Expressed in 227 organ(s), highest expression level in parotid gland. DR Genevisible; O76095; HS. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc. DR GO; GO:0016020; C:membrane; TAS:ProtInc. DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. DR GO; GO:0030496; C:midbody; IDA:UniProtKB. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell. DR GO; GO:0019901; F:protein kinase binding; IDA:UniProtKB. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0000278; P:mitotic cell cycle; IMP:UniProtKB. DR GO; GO:0000281; P:mitotic cytokinesis; IMP:UniProtKB. DR GO; GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB. DR InterPro; IPR008657; JTB. DR PANTHER; PTHR13041; PTHR13041; 1. DR Pfam; PF05439; JTB; 1. DR ProDom; PD151382; JTB; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Apoptosis; Cell cycle; KW Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; KW Mitochondrion; Mitosis; Polymorphism; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 30 {ECO:0000255}. FT CHAIN 31 146 Protein JTB. FT /FTId=PRO_0000021535. FT TOPO_DOM 31 105 Extracellular. {ECO:0000255}. FT TRANSMEM 106 126 Helical. {ECO:0000255}. FT TOPO_DOM 127 146 Cytoplasmic. {ECO:0000255}. FT VAR_SEQ 1 38 MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEK -> FT MAWGWHLSF (in isoform 2). FT {ECO:0000303|PubMed:11042152, FT ECO:0000303|PubMed:15489334}. FT /FTId=VSP_041400. FT VARIANT 16 16 L -> F (in dbSNP:rs34686244). FT /FTId=VAR_033994. FT TURN 49 51 {ECO:0000244|PDB:2KJX}. FT STRAND 54 62 {ECO:0000244|PDB:2KJX}. FT HELIX 65 70 {ECO:0000244|PDB:2KJX}. FT HELIX 72 74 {ECO:0000244|PDB:2KJX}. FT TURN 75 77 {ECO:0000244|PDB:2KJX}. FT STRAND 79 85 {ECO:0000244|PDB:2KJX}. FT TURN 86 89 {ECO:0000244|PDB:2KJX}. FT STRAND 90 95 {ECO:0000244|PDB:2KJX}. FT HELIX 98 101 {ECO:0000244|PDB:2KJX}. SQ SEQUENCE 146 AA; 16358 MW; CA7080543591C319 CRC64; MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL VEEFVVAEEC SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL MEQRLFWKFE GAVVCVALIF ACLVIIRQRQ LDRKALEKVR KQIESI //