ID NCTR1_HUMAN Reviewed; 304 AA. AC O76036; B0V3L2; B0V3L3; B0V3L4; B0V3L5; B8JL03; O76016; O76017; AC O76018; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 13-FEB-2019, entry version 158. DE RecName: Full=Natural cytotoxicity triggering receptor 1; DE AltName: Full=Lymphocyte antigen 94 homolog; DE AltName: Full=NK cell-activating receptor; DE AltName: Full=Natural killer cell p46-related protein; DE Short=NK-p46; DE Short=NKp46; DE Short=hNKp46; DE AltName: CD_antigen=CD335; DE Flags: Precursor; GN Name=NCR1; Synonyms=LY94; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, TISSUE RP SPECIFICITY, GLYCOSYLATION, AND INTERACTION WITH CD247. RC TISSUE=Lymphoid tissue; RX PubMed=9730896; DOI=10.1084/jem.188.5.953; RA Pessino A., Sivori S., Bottino C., Malaspina A., Morelli L., RA Moretta L., Biassoni R., Moretta A.; RT "Molecular cloning of NKp46: a novel member of the immunoglobulin RT superfamily involved in triggering of natural cytotoxicity."; RL J. Exp. Med. 188:953-960(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). RA Lin L., Yu R., Zhong J., Li H., Zhou G., Shen C., Ke R., Zheng G., RA Yang S.; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). RC TISSUE=Blood; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP REVIEW. RX PubMed=14754506; DOI=10.1111/j.1582-4934.2003.tb00240.x; RA Biassoni R., Cantoni C., Marras D., Giron-Michel J., Falco M., RA Moretta L., Dimasi N.; RT "Human natural killer cell receptors: insights into their molecular RT function and structure."; RL J. Cell. Mol. Med. 7:376-387(2003). RN [7] RP X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 25-212, AND DISULFIDE BONDS. RX PubMed=12951052; DOI=10.1016/j.bbrc.2003.08.007; RA Ponassi M., Cantoni C., Biassoni R., Conte R., Spallarossa A., RA Pesce A., Moretta A., Moretta L., Bolognesi M., Bordo D.; RT "Structure of the human NK cell triggering receptor NKp46 RT ectodomain."; RL Biochem. Biophys. Res. Commun. 309:317-323(2003). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-212, AND DISULFIDE BONDS. RX PubMed=12960161; DOI=10.1074/jbc.M308491200; RA Foster C.E., Colonna M., Sun P.D.; RT "Crystal structure of the human natural killer (NK) cell activating RT receptor NKp46 reveals structural relationship to other leukocyte RT receptor complex immunoreceptors."; RL J. Biol. Chem. 278:46081-46086(2003). RN [9] RP VARIANT [LARGE SCALE ANALYSIS] TYR-87. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Cytotoxicity-activating receptor that may contribute to CC the increased efficiency of activated natural killer (NK) cells to CC mediate tumor cell lysis. {ECO:0000269|PubMed:9730896}. CC -!- SUBUNIT: Interacts with CD247 and FCER1G. CC {ECO:0000269|PubMed:9730896}. CC -!- INTERACTION: CC P27918:CFP; NbExp=5; IntAct=EBI-13915737, EBI-15183949; CC P08670:VIM; NbExp=3; IntAct=EBI-13915737, EBI-353844; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass CC type I membrane protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=6; CC Name=1; CC IsoId=O76036-1; Sequence=Displayed; CC Note=No experimental confirmation available.; CC Name=2; Synonyms=b; CC IsoId=O76036-2; Sequence=VSP_010408; CC Note=No experimental confirmation available.; CC Name=3; Synonyms=c; CC IsoId=O76036-3; Sequence=VSP_010407; CC Note=No experimental confirmation available.; CC Name=4; Synonyms=d; CC IsoId=O76036-4; Sequence=VSP_010407, VSP_010408; CC Note=No experimental confirmation available.; CC Name=5; CC IsoId=O76036-5; Sequence=VSP_010406; CC Note=No experimental confirmation available.; CC Name=6; CC IsoId=O76036-6; Sequence=VSP_038384; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Selectively expressed by both resting and CC activated NK cells. {ECO:0000269|PubMed:9730896}. CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:9730896}. CC -!- PTM: O-glycosylated. {ECO:0000269|PubMed:9730896}. CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) CC family. {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AJ006121; CAA06872.1; -; mRNA. DR EMBL; AJ006122; CAA06873.1; -; mRNA. DR EMBL; AJ006123; CAA06874.1; -; mRNA. DR EMBL; AJ001383; CAA04714.1; -; mRNA. DR EMBL; AY346373; AAQ54328.1; -; mRNA. DR EMBL; CU151839; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU459006; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471135; EAW72308.1; -; Genomic_DNA. DR EMBL; CH471135; EAW72310.1; -; Genomic_DNA. DR EMBL; CH471135; EAW72311.1; -; Genomic_DNA. DR EMBL; BC064806; AAH64806.1; -; mRNA. DR CCDS; CCDS12911.1; -. [O76036-1] DR CCDS; CCDS46181.1; -. [O76036-6] DR CCDS; CCDS46182.1; -. [O76036-2] DR CCDS; CCDS56103.1; -. [O76036-3] DR RefSeq; NP_001138929.2; NM_001145457.2. DR RefSeq; NP_001138930.2; NM_001145458.2. DR RefSeq; NP_001229285.1; NM_001242356.2. [O76036-3] DR RefSeq; NP_001229286.1; NM_001242357.2. [O76036-4] DR RefSeq; NP_004820.2; NM_004829.6. DR UniGene; Hs.97084; -. DR PDB; 1OLL; X-ray; 1.93 A; A=25-212. DR PDB; 1P6F; X-ray; 2.20 A; A=22-263. DR PDBsum; 1OLL; -. DR PDBsum; 1P6F; -. DR ProteinModelPortal; O76036; -. DR SMR; O76036; -. DR BioGrid; 114828; 5. DR IntAct; O76036; 8. DR STRING; 9606.ENSP00000291890; -. DR iPTMnet; O76036; -. DR PhosphoSitePlus; O76036; -. DR BioMuta; NCR1; -. DR PaxDb; O76036; -. DR PeptideAtlas; O76036; -. DR PRIDE; O76036; -. DR ProteomicsDB; 50352; -. DR ProteomicsDB; 50353; -. [O76036-2] DR ProteomicsDB; 50354; -. [O76036-3] DR ProteomicsDB; 50355; -. [O76036-4] DR ProteomicsDB; 50356; -. [O76036-5] DR ProteomicsDB; 50357; -. [O76036-6] DR DNASU; 9437; -. DR Ensembl; ENST00000350790; ENSP00000344358; ENSG00000189430. [O76036-3] DR Ensembl; ENST00000357397; ENSP00000349972; ENSG00000189430. [O76036-5] DR Ensembl; ENST00000610621; ENSP00000483452; ENSG00000273535. [O76036-1] DR Ensembl; ENST00000610753; ENSP00000484377; ENSG00000273535. [O76036-3] DR Ensembl; ENST00000611098; ENSP00000479222; ENSG00000275156. [O76036-5] DR Ensembl; ENST00000611105; ENSP00000483028; ENSG00000278362. [O76036-3] DR Ensembl; ENST00000611942; ENSP00000483723; ENSG00000275156. [O76036-2] DR Ensembl; ENST00000612239; ENSP00000481692; ENSG00000275156. [O76036-6] DR Ensembl; ENST00000612645; ENSP00000481540; ENSG00000275156. [O76036-3] DR Ensembl; ENST00000612896; ENSP00000484520; ENSG00000278362. [O76036-1] DR Ensembl; ENST00000613135; ENSP00000480145; ENSG00000278362. [O76036-5] DR Ensembl; ENST00000613556; ENSP00000482092; ENSG00000273535. [O76036-5] DR Ensembl; ENST00000615622; ENSP00000478507; ENSG00000273535. [O76036-1] DR Ensembl; ENST00000617154; ENSP00000481971; ENSG00000275156. [O76036-1] DR Ensembl; ENST00000617784; ENSP00000482423; ENSG00000278362. [O76036-1] DR Ensembl; ENST00000618973; ENSP00000483611; ENSG00000273535. [O76036-2] DR Ensembl; ENST00000619077; ENSP00000484221; ENSG00000273535. [O76036-1] DR Ensembl; ENST00000619451; ENSP00000482536; ENSG00000278362. [O76036-6] DR Ensembl; ENST00000620296; ENSP00000484067; ENSG00000278362. [O76036-2] DR Ensembl; ENST00000621059; ENSP00000484831; ENSG00000278362. [O76036-4] DR Ensembl; ENST00000621652; ENSP00000477625; ENSG00000273535. [O76036-4] DR Ensembl; ENST00000639155; ENSP00000491020; ENSG00000284113. [O76036-5] DR Ensembl; ENST00000640377; ENSP00000491933; ENSG00000284208. [O76036-5] DR Ensembl; ENST00000640753; ENSP00000492673; ENSG00000284208. [O76036-3] DR Ensembl; ENST00000640987; ENSP00000492426; ENSG00000284113. [O76036-3] DR GeneID; 9437; -. DR KEGG; hsa:9437; -. DR UCSC; uc002qid.3; human. [O76036-1] DR CTD; 9437; -. DR DisGeNET; 9437; -. DR EuPathDB; HostDB:ENSG00000189430.12; -. DR GeneCards; NCR1; -. DR HGNC; HGNC:6731; NCR1. DR HPA; HPA049311; -. DR MIM; 604530; gene. DR neXtProt; NX_O76036; -. DR OpenTargets; ENSG00000189430; -. DR PharmGKB; PA30495; -. DR eggNOG; ENOG410IX2G; Eukaryota. DR eggNOG; ENOG4111ACT; LUCA. DR GeneTree; ENSGT00940000153328; -. DR HOGENOM; HOG000234395; -. DR HOVERGEN; HBG074353; -. DR InParanoid; O76036; -. DR KO; K06741; -. DR OrthoDB; 1327293at2759; -. DR PhylomeDB; O76036; -. DR TreeFam; TF336644; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR ChiTaRS; NCR1; human. DR EvolutionaryTrace; O76036; -. DR GeneWiki; NCR1; -. DR GenomeRNAi; 9437; -. DR PRO; PR:O76036; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000189430; Expressed in 73 organ(s), highest expression level in blood. DR ExpressionAtlas; O76036; baseline and differential. DR Genevisible; O76036; HS. DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0016514; C:SWI/SNF complex; ISS:UniProtKB. DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc. DR GO; GO:0030101; P:natural killer cell activation; NAS:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0042269; P:regulation of natural killer cell mediated cytotoxicity; TAS:UniProtKB. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR Gene3D; 2.60.40.10; -; 2. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR SMART; SM00409; IG; 2. DR SUPFAM; SSF48726; SSF48726; 2. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; KW Polymorphism; Receptor; Reference proteome; Repeat; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 21 {ECO:0000255}. FT CHAIN 22 304 Natural cytotoxicity triggering receptor FT 1. FT /FTId=PRO_0000015027. FT TOPO_DOM 22 258 Extracellular. {ECO:0000255}. FT TRANSMEM 259 279 Helical. {ECO:0000255}. FT TOPO_DOM 280 304 Cytoplasmic. {ECO:0000255}. FT DOMAIN 34 118 Ig-like 1. FT DOMAIN 129 211 Ig-like 2. FT CARBOHYD 216 216 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 49 98 {ECO:0000244|PDB:1OLL, FT ECO:0000244|PDB:1P6F, FT ECO:0000269|PubMed:12960161, FT ECO:0000269|PubMed:16959974}. FT DISULFID 144 190 {ECO:0000244|PDB:1OLL, FT ECO:0000244|PDB:1P6F, FT ECO:0000269|PubMed:12960161, FT ECO:0000269|PubMed:16959974}. FT VAR_SEQ 12 118 Missing (in isoform 5). FT {ECO:0000303|Ref.2}. FT /FTId=VSP_010406. FT VAR_SEQ 25 119 Missing (in isoform 3 and isoform 4). FT {ECO:0000303|PubMed:9730896}. FT /FTId=VSP_010407. FT VAR_SEQ 228 244 Missing (in isoform 2 and isoform 4). FT {ECO:0000303|PubMed:9730896}. FT /FTId=VSP_010408. FT VAR_SEQ 228 228 Missing (in isoform 6). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_038384. FT VARIANT 82 82 K -> Q (in dbSNP:rs2278428). FT /FTId=VAR_018633. FT VARIANT 87 87 D -> Y (in a colorectal cancer sample; FT somatic mutation). FT {ECO:0000269|PubMed:16959974}. FT /FTId=VAR_035527. FT STRAND 30 35 {ECO:0000244|PDB:1OLL}. FT STRAND 37 40 {ECO:0000244|PDB:1OLL}. FT STRAND 45 50 {ECO:0000244|PDB:1OLL}. FT STRAND 57 62 {ECO:0000244|PDB:1OLL}. FT STRAND 65 70 {ECO:0000244|PDB:1OLL}. FT STRAND 80 87 {ECO:0000244|PDB:1OLL}. FT HELIX 90 92 {ECO:0000244|PDB:1OLL}. FT STRAND 94 102 {ECO:0000244|PDB:1OLL}. FT STRAND 113 119 {ECO:0000244|PDB:1OLL}. FT STRAND 125 130 {ECO:0000244|PDB:1OLL}. FT STRAND 132 135 {ECO:0000244|PDB:1OLL}. FT STRAND 139 145 {ECO:0000244|PDB:1OLL}. FT STRAND 147 149 {ECO:0000244|PDB:1OLL}. FT STRAND 151 161 {ECO:0000244|PDB:1OLL}. FT STRAND 163 168 {ECO:0000244|PDB:1OLL}. FT STRAND 170 179 {ECO:0000244|PDB:1OLL}. FT HELIX 182 184 {ECO:0000244|PDB:1OLL}. FT STRAND 186 191 {ECO:0000244|PDB:1OLL}. FT STRAND 193 195 {ECO:0000244|PDB:1OLL}. FT STRAND 206 211 {ECO:0000244|PDB:1OLL}. SQ SEQUENCE 304 AA; 34481 MW; FBCBDE50D2F34CD3 CRC64; MSSTLPALLC VGLCLSQRIS AQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEKV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS FPSEPVKLLV TGDIENTSLA PEDPTFPADT WGTYLLTTET GLQKDHALWD HTAQNLLRMG LAFLVLVALV WFLVEDWLSR KRTRERASRA STWEGRRRLN TQTL //