ID SPI2_HUMAN Reviewed; 405 AA. AC O75830; DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 13-FEB-2019, entry version 161. DE RecName: Full=Serpin I2; DE AltName: Full=Myoepithelium-derived serine protease inhibitor; DE AltName: Full=Pancpin; DE AltName: Full=Pancreas-specific protein TSA2004; DE AltName: Full=Peptidase inhibitor 14; DE Short=PI-14; DE Flags: Precursor; GN Name=SERPINI2; Synonyms=MEPI, PI14; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=9624529; RX DOI=10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.3.CO;2-U; RA Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O., RA Ohigashi H., Imaoka S., Takahashi E., Nakamura Y.; RT "Isolation and characterization of a novel human pancreas-specific RT gene, pancpin, that is down-regulated in pancreatic cancer cells."; RL Genes Chromosomes Cancer 22:179-185(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=10097100; DOI=10.1073/pnas.96.7.3700; RA Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., RA Shi Y.E.; RT "Suppression of breast cancer growth and metastasis by a serpin RT myoepithelium-derived serine proteinase inhibitor expressed in the RT mammary myoepithelial cells."; RL Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pancreas, and Spleen; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q96EQ0:SGTB; NbExp=3; IntAct=EBI-750144, EBI-744081; CC Q9UMX0:UBQLN1; NbExp=8; IntAct=EBI-750144, EBI-741480; CC Q9UMX0-2:UBQLN1; NbExp=3; IntAct=EBI-750144, EBI-10173939; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Expressed in pancreas and adipose tissues. CC {ECO:0000269|PubMed:9624529}. CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH27859.2; Type=Erroneous initiation; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB006423; BAA33766.1; -; mRNA. DR EMBL; AF130470; AAD34723.1; -; mRNA. DR EMBL; BC027859; AAH27859.2; ALT_INIT; mRNA. DR CCDS; CCDS3200.1; -. DR RefSeq; NP_001012303.1; NM_001012303.2. DR RefSeq; NP_006208.1; NM_006217.4. DR UniGene; Hs.445555; -. DR ProteinModelPortal; O75830; -. DR BioGrid; 111294; 6. DR IntAct; O75830; 8. DR MINT; O75830; -. DR STRING; 9606.ENSP00000264677; -. DR MEROPS; I04.026; -. DR iPTMnet; O75830; -. DR PhosphoSitePlus; O75830; -. DR BioMuta; SERPINI2; -. DR EPD; O75830; -. DR jPOST; O75830; -. DR PaxDb; O75830; -. DR PeptideAtlas; O75830; -. DR PRIDE; O75830; -. DR ProteomicsDB; 50219; -. DR DNASU; 5276; -. DR Ensembl; ENST00000264677; ENSP00000264677; ENSG00000114204. DR Ensembl; ENST00000461846; ENSP00000417692; ENSG00000114204. DR Ensembl; ENST00000471111; ENSP00000419407; ENSG00000114204. DR Ensembl; ENST00000476257; ENSP00000420621; ENSG00000114204. DR GeneID; 5276; -. DR KEGG; hsa:5276; -. DR UCSC; uc003fer.3; human. DR CTD; 5276; -. DR DisGeNET; 5276; -. DR EuPathDB; HostDB:ENSG00000114204.14; -. DR GeneCards; SERPINI2; -. DR HGNC; HGNC:8945; SERPINI2. DR MIM; 605587; gene. DR neXtProt; NX_O75830; -. DR OpenTargets; ENSG00000114204; -. DR PharmGKB; PA35513; -. DR eggNOG; KOG2392; Eukaryota. DR eggNOG; COG4826; LUCA. DR GeneTree; ENSGT00940000161641; -. DR HOVERGEN; HBG005957; -. DR InParanoid; O75830; -. DR OrthoDB; 1124079at2759; -. DR PhylomeDB; O75830; -. DR TreeFam; TF343094; -. DR ChiTaRS; SERPINI2; human. DR GeneWiki; SERPINI2; -. DR GenomeRNAi; 5276; -. DR PRO; PR:O75830; -. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000114204; Expressed in 109 organ(s), highest expression level in body of pancreas. DR ExpressionAtlas; O75830; baseline and differential. DR Genevisible; O75830; HS. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central. DR InterPro; IPR023795; Serpin_CS. DR InterPro; IPR023796; Serpin_dom. DR InterPro; IPR000215; Serpin_fam. DR InterPro; IPR036186; Serpin_sf. DR PANTHER; PTHR11461; PTHR11461; 1. DR Pfam; PF00079; Serpin; 1. DR SMART; SM00093; SERPIN; 1. DR SUPFAM; SSF56574; SSF56574; 1. DR PROSITE; PS00284; SERPIN; 1. PE 1: Evidence at protein level; KW Complete proteome; Glycoprotein; Polymorphism; Protease inhibitor; KW Reference proteome; Secreted; Serine protease inhibitor; Signal. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 405 Serpin I2. FT /FTId=PRO_0000032525. FT SITE 357 358 Reactive bond. {ECO:0000250}. FT CARBOHYD 202 202 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 207 207 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 306 306 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT VARIANT 6 6 L -> V (in dbSNP:rs17246389). FT /FTId=VAR_051957. FT VARIANT 148 148 E -> G (in dbSNP:rs9841174). FT /FTId=VAR_024357. SQ SEQUENCE 405 AA; 46145 MW; 5BA18C60E4FDE9A4 CRC64; MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL //