ID   SCRG1_HUMAN             Reviewed;          98 AA.
AC   O75711;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JAN-2019, entry version 122.
DE   RecName: Full=Scrapie-responsive protein 1;
DE   AltName: Full=Scrapie-responsive gene 1 protein;
DE            Short=ScRG-1;
DE   Flags: Precursor;
GN   Name=SCRG1; ORFNames=UNQ390/PRO725;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9660755; DOI=10.1074/jbc.273.29.18015;
RA   Dron M., Dandoy-Dron F., Guillo F., Benboudjema L., Hauw J.-J.,
RA   Lebon P., Dormont D., Tovey M.G.;
RT   "Characterization of the human analogue of a scrapie-responsive
RT   gene.";
RL   J. Biol. Chem. 273:18015-18018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   PROTEIN SEQUENCE OF 21-35.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- INTERACTION:
CC       Q8NEC5:CATSPER1; NbExp=3; IntAct=EBI-10189029, EBI-744545;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed abundantly in the central nervous
CC       system of adult, but not at all in fetal brain. High levels of
CC       SCRG1 transcripts are also observed in testis and aorta.
CC   -!- SIMILARITY: Belongs to the SCRG1 family. {ECO:0000305}.
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DR   EMBL; AJ224677; CAA12059.1; -; mRNA.
DR   EMBL; AY359040; AAQ89399.1; -; mRNA.
DR   CCDS; CCDS3818.1; -.
DR   RefSeq; NP_001316526.1; NM_001329597.1.
DR   RefSeq; NP_009212.1; NM_007281.3.
DR   UniGene; Hs.7122; -.
DR   ProteinModelPortal; O75711; -.
DR   SMR; O75711; -.
DR   BioGrid; 116469; 1.
DR   IntAct; O75711; 4.
DR   STRING; 9606.ENSP00000296506; -.
DR   iPTMnet; O75711; -.
DR   PhosphoSitePlus; O75711; -.
DR   BioMuta; SCRG1; -.
DR   PaxDb; O75711; -.
DR   PeptideAtlas; O75711; -.
DR   PRIDE; O75711; -.
DR   ProteomicsDB; 50169; -.
DR   DNASU; 11341; -.
DR   Ensembl; ENST00000296506; ENSP00000296506; ENSG00000164106.
DR   GeneID; 11341; -.
DR   KEGG; hsa:11341; -.
DR   CTD; 11341; -.
DR   EuPathDB; HostDB:ENSG00000164106.7; -.
DR   GeneCards; SCRG1; -.
DR   HGNC; HGNC:17036; SCRG1.
DR   HPA; HPA012882; -.
DR   MIM; 603163; gene.
DR   neXtProt; NX_O75711; -.
DR   OpenTargets; ENSG00000164106; -.
DR   PharmGKB; PA165664478; -.
DR   eggNOG; ENOG410J0WG; Eukaryota.
DR   eggNOG; ENOG410YPGI; LUCA.
DR   GeneTree; ENSGT00390000009191; -.
DR   HOGENOM; HOG000294139; -.
DR   HOVERGEN; HBG054216; -.
DR   InParanoid; O75711; -.
DR   OMA; IFFGPKI; -.
DR   OrthoDB; 1523830at2759; -.
DR   PhylomeDB; O75711; -.
DR   TreeFam; TF335779; -.
DR   ChiTaRS; SCRG1; human.
DR   GenomeRNAi; 11341; -.
DR   PRO; PR:O75711; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000164106; Expressed in 184 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; O75711; baseline and differential.
DR   Genevisible; O75711; HS.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0044306; C:neuron projection terminus; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   InterPro; IPR028063; SCRG1.
DR   PANTHER; PTHR17463; PTHR17463; 1.
DR   Pfam; PF15224; SCRG1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Glycoprotein;
KW   Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     20       {ECO:0000269|PubMed:15340161}.
FT   CHAIN        21     98       Scrapie-responsive protein 1.
FT                                /FTId=PRO_0000022283.
FT   CARBOHYD     72     72       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VARIANT      42     42       P -> L (in dbSNP:rs2306465).
FT                                /FTId=VAR_020329.
SQ   SEQUENCE   98 AA;  11081 MW;  A5F1FD40BF5401C0 CRC64;
     MKLMVLVFTI GLTLLLGVQA MPANRLSCYR KILKDHNCHN LPEGVADLTQ IDVNVQDHFW
     DGKGCEMICY CNFSELLCCP KDVFFGPKIS FVIPCNNQ
//