ID   CAH11_HUMAN             Reviewed;         328 AA.
AC   O75493; O60596; Q6FHI1; Q9UEC4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   13-FEB-2019, entry version 154.
DE   RecName: Full=Carbonic anhydrase-related protein 11;
DE   AltName: Full=CA-RP XI;
DE            Short=CA-XI;
DE            Short=CARP XI;
DE   AltName: Full=Carbonic anhydrase-related protein 2;
DE            Short=CA-RP II;
DE            Short=CARP-2;
DE   Flags: Precursor;
GN   Name=CA11; Synonyms=CARP2; ORFNames=UNQ211/PRO237;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9878543; DOI=10.1006/bbrc.1998.9449;
RA   Bellingham J., Gregory-Evans K., Gregory-Evans C.Y.;
RT   "Sequence and tissue expression of a novel human carbonic anhydrase-
RT   related protein, CARP-2, mapping to chromosome 19q13.3.";
RL   Biochem. Biophys. Res. Commun. 253:364-367(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=10350627; DOI=10.1016/S0167-4838(99)00067-9;
RA   Fujikawa-Adachi K., Nishimori I., Taguchi T., Yuri K., Onishi S.;
RT   "cDNA sequence, mRNA expression, and chromosomal localization of human
RT   carbonic anhydrase-related protein, CA-RP XI.";
RL   Biochim. Biophys. Acta 1431:518-524(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA   Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA   Korn B., Zuo D., Hu Y., LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 48-314.
RC   TISSUE=Brain;
RX   PubMed=9878252; DOI=10.1006/geno.1998.5585;
RA   Lovejoy D.A., Hewett-Emmett D., Porter C.A., Cepoi D., Sheffield A.,
RA   Vale W.W., Tashian R.E.;
RT   "Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related
RT   protein XI contains a sequence motif present in the neuropeptide
RT   sauvagine: the human CA-RP XI gene (CA11) is embedded between the
RT   secretor gene cluster and the DBP gene at 19q13.3.";
RL   Genomics 54:484-493(1998).
RN   [8]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
RC   TISSUE=Plasma;
RX   PubMed=16335952; DOI=10.1021/pr0502065;
RA   Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA   Moore R.J., Smith R.D.;
RT   "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT   hydrazide chemistry, and mass spectrometry.";
RL   J. Proteome Res. 4:2070-2080(2005).
CC   -!- FUNCTION: Does not have a catalytic activity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed abundantly in the brain with
CC       moderate expression also present in spinal cord and thyroid.
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC       {ECO:0000305}.
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DR   EMBL; AF067662; AAC99689.1; -; mRNA.
DR   EMBL; AB018195; BAA36840.1; -; mRNA.
DR   EMBL; AY358967; AAQ89326.1; -; mRNA.
DR   EMBL; CR541772; CAG46571.1; -; mRNA.
DR   EMBL; BT007265; AAP35929.1; -; mRNA.
DR   EMBL; BC002662; AAH02662.1; -; mRNA.
DR   EMBL; AF050106; AAD08802.1; -; mRNA.
DR   CCDS; CCDS12729.1; -.
DR   PIR; JE0375; JE0375.
DR   RefSeq; NP_001208.2; NM_001217.4.
DR   UniGene; Hs.428446; -.
DR   ProteinModelPortal; O75493; -.
DR   SMR; O75493; -.
DR   BioGrid; 107224; 6.
DR   STRING; 9606.ENSP00000084798; -.
DR   ChEMBL; CHEMBL2420; -.
DR   DrugBank; DB00909; Zonisamide.
DR   iPTMnet; O75493; -.
DR   PhosphoSitePlus; O75493; -.
DR   BioMuta; CA11; -.
DR   PaxDb; O75493; -.
DR   PeptideAtlas; O75493; -.
DR   PRIDE; O75493; -.
DR   ProteomicsDB; 50047; -.
DR   DNASU; 770; -.
DR   Ensembl; ENST00000084798; ENSP00000084798; ENSG00000063180.
DR   GeneID; 770; -.
DR   KEGG; hsa:770; -.
DR   UCSC; uc002pjz.2; human.
DR   CTD; 770; -.
DR   DisGeNET; 770; -.
DR   EuPathDB; HostDB:ENSG00000063180.8; -.
DR   GeneCards; CA11; -.
DR   HGNC; HGNC:1370; CA11.
DR   HPA; HPA041778; -.
DR   MIM; 604644; gene.
DR   neXtProt; NX_O75493; -.
DR   OpenTargets; ENSG00000063180; -.
DR   PharmGKB; PA25986; -.
DR   eggNOG; KOG0382; Eukaryota.
DR   eggNOG; COG3338; LUCA.
DR   GeneTree; ENSGT00940000162098; -.
DR   HOGENOM; HOG000019899; -.
DR   HOVERGEN; HBG097666; -.
DR   InParanoid; O75493; -.
DR   OMA; AVSWEEW; -.
DR   OrthoDB; 1377476at2759; -.
DR   PhylomeDB; O75493; -.
DR   TreeFam; TF352926; -.
DR   ChiTaRS; CA11; human.
DR   GeneWiki; CA11; -.
DR   GenomeRNAi; 770; -.
DR   PRO; PR:O75493; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000063180; Expressed in 205 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; O75493; baseline and differential.
DR   Genevisible; O75493; HS.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.10.200.10; -; 1.
DR   InterPro; IPR001148; CA_dom.
DR   InterPro; IPR036398; CA_dom_sf.
DR   InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR   PANTHER; PTHR18952; PTHR18952; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   SMART; SM01057; Carb_anhydrase; 1.
DR   SUPFAM; SSF51069; SSF51069; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    328       Carbonic anhydrase-related protein 11.
FT                                /FTId=PRO_0000004245.
FT   DOMAIN       33    303       Alpha-carbonic anhydrase.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01134}.
FT   CARBOHYD    118    118       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:16335952}.
FT   CARBOHYD    170    170       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    260    260       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT     23     24       AH -> GN (in Ref. 2; BAA36840).
FT                                {ECO:0000305}.
FT   CONFLICT     75     75       L -> V (in Ref. 1; AAC99689).
FT                                {ECO:0000305}.
FT   CONFLICT    280    280       I -> M (in Ref. 7; AAD08802).
FT                                {ECO:0000305}.
SQ   SEQUENCE   328 AA;  36238 MW;  A4FC408718B2E857 CRC64;
     MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS
     LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS
     GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN FSAASRGPNG
     LAILSLFVNV ASTSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS
     LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR
     GNRDPRHPER RCRGPNYRLH VDGVPHGR
//