ID   GPC4_HUMAN              Reviewed;         556 AA.
AC   O75487; B2R6J7; B4E2C0; Q6ZMA6; Q96L43; Q9NU08; Q9UJN1; Q9UPD9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2003, sequence version 4.
DT   13-FEB-2019, entry version 169.
DE   RecName: Full=Glypican-4;
DE   AltName: Full=K-glypican;
DE   Contains:
DE     RecName: Full=Secreted glypican-4;
DE   Flags: Precursor;
GN   Name=GPC4; ORFNames=UNQ474/PRO937;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ASP-391 AND
RP   VAL-442.
RC   TISSUE=Brain;
RX   PubMed=9787072; DOI=10.1006/geno.1998.5465;
RA   Veugelers M., Vermeesch J., Watanabe K., Yamaguchi Y., Marynen P.,
RA   David G.;
RT   "GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of
RT   the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel
RT   syndrome.";
RL   Genomics 53:1-11(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-391.
RA   Pilia G., Mazzarella R., Huber R., Crisponi L., Lindsay S.,
RA   Ireland M., Cao A., Schlessinger D.;
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ASP-391 AND
RP   VAL-442.
RA   Zhang B., Feng Z., Zhou Y., Peng X., Yuan J., Qiang B.;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [10]
RP   VARIANTS ASP-391 AND VAL-442.
RX   PubMed=10814714; DOI=10.1093/hmg/9.9.1321;
RA   Veugelers M., Cat B.D., Muyldermans S.Y., Reekmans G., Delande N.,
RA   Frints S., Legius E., Fryns J.-P., Schrander-Stumpel C., Weidle B.,
RA   Magdalena N., David G.;
RT   "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in
RT   patients with Simpson-Golabi-Behmel syndrome: identification of loss-
RT   of-function mutations in the GPC3 gene.";
RL   Hum. Mol. Genet. 9:1321-1328(2000).
CC   -!- FUNCTION: Cell surface proteoglycan that bears heparan sulfate.
CC       May be involved in the development of kidney tubules and of the
CC       central nervous system (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor,
CC       GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted glypican-4: Secreted, extracellular
CC       space {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O75487-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O75487-2; Sequence=VSP_056570;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the glypican family. {ECO:0000305}.
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DR   EMBL; AF030186; AAC69991.1; -; mRNA.
DR   EMBL; AF064826; AAC31899.1; -; mRNA.
DR   EMBL; AY358507; AAQ88871.1; -; mRNA.
DR   EMBL; AY052833; AAL11018.1; -; mRNA.
DR   EMBL; AK304207; BAG65082.1; -; mRNA.
DR   EMBL; AK312605; BAG35494.1; -; mRNA.
DR   EMBL; AL034400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL109623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471107; EAX11772.1; -; Genomic_DNA.
DR   EMBL; BC017166; AAH17166.1; -; mRNA.
DR   CCDS; CCDS14637.1; -. [O75487-1]
DR   RefSeq; NP_001439.2; NM_001448.2. [O75487-1]
DR   UniGene; Hs.58367; -.
DR   ProteinModelPortal; O75487; -.
DR   SMR; O75487; -.
DR   BioGrid; 108530; 28.
DR   IntAct; O75487; 13.
DR   MINT; O75487; -.
DR   STRING; 9606.ENSP00000359864; -.
DR   iPTMnet; O75487; -.
DR   PhosphoSitePlus; O75487; -.
DR   BioMuta; GPC4; -.
DR   EPD; O75487; -.
DR   jPOST; O75487; -.
DR   MaxQB; O75487; -.
DR   PaxDb; O75487; -.
DR   PeptideAtlas; O75487; -.
DR   PRIDE; O75487; -.
DR   ProteomicsDB; 50045; -.
DR   DNASU; 2239; -.
DR   Ensembl; ENST00000370828; ENSP00000359864; ENSG00000076716. [O75487-1]
DR   GeneID; 2239; -.
DR   KEGG; hsa:2239; -.
DR   UCSC; uc004exc.2; human. [O75487-1]
DR   CTD; 2239; -.
DR   DisGeNET; 2239; -.
DR   EuPathDB; HostDB:ENSG00000076716.8; -.
DR   GeneCards; GPC4; -.
DR   GeneReviews; GPC4; -.
DR   HGNC; HGNC:4452; GPC4.
DR   HPA; HPA030836; -.
DR   MalaCards; GPC4; -.
DR   MIM; 300168; gene.
DR   neXtProt; NX_O75487; -.
DR   OpenTargets; ENSG00000076716; -.
DR   Orphanet; 373; Simpson-Golabi-Behmel syndrome.
DR   PharmGKB; PA28833; -.
DR   eggNOG; KOG3821; Eukaryota.
DR   eggNOG; ENOG410XST2; LUCA.
DR   GeneTree; ENSGT00940000153644; -.
DR   HOVERGEN; HBG003464; -.
DR   InParanoid; O75487; -.
DR   KO; K08110; -.
DR   OMA; QCPSEFE; -.
DR   OrthoDB; 1362554at2759; -.
DR   PhylomeDB; O75487; -.
DR   TreeFam; TF105317; -.
DR   Reactome; R-HSA-1971475; A tetrasaccharide linker sequence is required for GAG synthesis.
DR   Reactome; R-HSA-2022928; HS-GAG biosynthesis.
DR   Reactome; R-HSA-2024096; HS-GAG degradation.
DR   Reactome; R-HSA-3560783; Defective B4GALT7 causes EDS, progeroid type.
DR   Reactome; R-HSA-3560801; Defective B3GAT3 causes JDSSDHD.
DR   Reactome; R-HSA-3656237; Defective EXT2 causes exostoses 2.
DR   Reactome; R-HSA-3656253; Defective EXT1 causes exostoses 1, TRPS2 and CHDS.
DR   Reactome; R-HSA-4420332; Defective B3GALT6 causes EDSP2 and SEMDJL1.
DR   Reactome; R-HSA-975634; Retinoid metabolism and transport.
DR   SIGNOR; O75487; -.
DR   ChiTaRS; GPC4; human.
DR   GeneWiki; Glypican_4; -.
DR   GenomeRNAi; 2239; -.
DR   PRO; PR:O75487; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   Bgee; ENSG00000076716; Expressed in 177 organ(s), highest expression level in lower esophagus.
DR   Genevisible; O75487; HS.
DR   GO; GO:0099026; C:anchored component of presynaptic membrane; IEA:Ensembl.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR   GO; GO:0043202; C:lysosomal lumen; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:1904929; F:coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; NAS:ParkinsonsUK-UCL.
DR   GO; GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
DR   GO; GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
DR   GO; GO:0098696; P:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
DR   GO; GO:1905606; P:regulation of presynapse assembly; IEA:Ensembl.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   GO; GO:0001523; P:retinoid metabolic process; TAS:Reactome.
DR   GO; GO:0099560; P:synaptic membrane adhesion; IEA:Ensembl.
DR   InterPro; IPR001863; Glypican.
DR   InterPro; IPR031180; Glypican-4.
DR   InterPro; IPR019803; Glypican_CS.
DR   PANTHER; PTHR10822; PTHR10822; 1.
DR   PANTHER; PTHR10822:SF25; PTHR10822:SF25; 1.
DR   Pfam; PF01153; Glypican; 1.
DR   PROSITE; PS01207; GLYPICAN; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Complete proteome; Glycoprotein;
KW   GPI-anchor; Heparan sulfate; Lipoprotein; Membrane; Phosphoprotein;
KW   Polymorphism; Proteoglycan; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19    529       Glypican-4.
FT                                /FTId=PRO_0000012315.
FT   CHAIN        19      ?       Secreted glypican-4.
FT                                /FTId=PRO_0000333847.
FT   PROPEP      530    556       Removed in mature form. {ECO:0000255}.
FT                                /FTId=PRO_0000012316.
FT   MOD_RES     357    357       Phosphoserine.
FT                                {ECO:0000244|PubMed:21406692}.
FT   LIPID       529    529       GPI-anchor amidated serine.
FT                                {ECO:0000255}.
FT   CARBOHYD    494    494       O-linked (Xyl...) (glycosaminoglycan)
FT                                serine. {ECO:0000255}.
FT   CARBOHYD    498    498       O-linked (Xyl...) (glycosaminoglycan)
FT                                serine. {ECO:0000255}.
FT   CARBOHYD    500    500       O-linked (Xyl...) (glycosaminoglycan)
FT                                serine. {ECO:0000255}.
FT   CARBOHYD    514    514       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ       1     70       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_056570.
FT   VARIANT     391    391       E -> D (in dbSNP:rs1129980).
FT                                {ECO:0000269|PubMed:10814714,
FT                                ECO:0000269|PubMed:9787072,
FT                                ECO:0000269|Ref.2, ECO:0000269|Ref.3}.
FT                                /FTId=VAR_016191.
FT   VARIANT     442    442       A -> V (in dbSNP:rs1048369).
FT                                {ECO:0000269|PubMed:10814714,
FT                                ECO:0000269|PubMed:9787072,
FT                                ECO:0000269|Ref.3}.
FT                                /FTId=VAR_016192.
SQ   SEQUENCE   556 AA;  62412 MW;  827E07FAA0BD8188 CRC64;
     MARFGLPALL CTLAVLSAAL LAAELKSKSC SEVRRLYVSK GFNKNDAPLH EINGDHLKIC
     PQGSTCCSQE MEEKYSLQSK DDFKSVVSEQ CNHLQAVFAS RYKKFDEFFK ELLENAEKSL
     NDMFVKTYGH LYMQNSELFK DLFVELKRYY VVGNVNLEEM LNDFWARLLE RMFRLVNSQY
     HFTDEYLECV SKYTEQLKPF GDVPRKLKLQ VTRAFVAART FAQGLAVAGD VVSKVSVVNP
     TAQCTHALLK MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE
     RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG RISRSISESA
     FSARFRPHHP EERPTTAAGT SLDRLVTDVK EKLKQAKKFW SSLPSNVCND ERMAAGNGNE
     DDCWNGKGKS RYLFAVTGNG LANQGNNPEV QVDTSKPDIL ILRQIMALRV MTSKMKNAYN
     GNDVDFFDIS DESSGEGSGS GCEYQQCPSE FDYNATDHAG KSANEKADSA GVRPGAQAYL
     LTVFCILFLV MQREWR
//