ID LRRN2_HUMAN Reviewed; 713 AA. AC O75325; B2R624; Q5T0Y0; Q6UXM0; Q8N182; DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot. DT 15-MAR-2005, sequence version 2. DT 13-FEB-2019, entry version 171. DE RecName: Full=Leucine-rich repeat neuronal protein 2; DE AltName: Full=Glioma amplified on chromosome 1 protein; DE AltName: Full=Leucine-rich repeat neuronal protein 5; DE Flags: Precursor; GN Name=LRRN2; Synonyms=GAC1, LRRN5; ORFNames=UNQ256/PRO293; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Glial tumor; RX PubMed=9662332; DOI=10.1038/sj.onc.1201828; RA Malfoy B., Almeida A., Zhu X.X., Vogt N., Tyagi R., Muleris M., RA Dutrillaux A.-M., Dutrillaux B., Ross D., Hanash S.; RT "GAC1, a new member of the leucine-rich repeat superfamily on RT chromosome band 1q32.1, is amplified and overexpressed in malignant RT gliomas."; RL Oncogene 16:2997-3002(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-19. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I CC membrane protein {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Overamplified in malignant gliomas. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF030435; AAC39792.1; -; mRNA. DR EMBL; AY358290; AAQ88657.1; -; mRNA. DR EMBL; AK312408; BAG35321.1; -; mRNA. DR EMBL; AL512306; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471067; EAW91520.1; -; Genomic_DNA. DR EMBL; BC034047; AAH34047.1; -; mRNA. DR EMBL; BC068541; AAH68541.1; -; mRNA. DR CCDS; CCDS1448.1; -. DR RefSeq; NP_006329.2; NM_006338.2. DR RefSeq; NP_963924.1; NM_201630.1. DR RefSeq; XP_005244884.1; XM_005244827.3. DR RefSeq; XP_011507368.1; XM_011509066.2. DR RefSeq; XP_016855539.1; XM_017000050.1. DR UniGene; Hs.26312; -. DR ProteinModelPortal; O75325; -. DR BioGrid; 115711; 18. DR IntAct; O75325; 1. DR STRING; 9606.ENSP00000356143; -. DR iPTMnet; O75325; -. DR PhosphoSitePlus; O75325; -. DR BioMuta; LRRN2; -. DR MaxQB; O75325; -. DR PaxDb; O75325; -. DR PeptideAtlas; O75325; -. DR PRIDE; O75325; -. DR ProteomicsDB; 49895; -. DR DNASU; 10446; -. DR Ensembl; ENST00000367175; ENSP00000356143; ENSG00000170382. DR Ensembl; ENST00000367176; ENSP00000356144; ENSG00000170382. DR Ensembl; ENST00000367177; ENSP00000356145; ENSG00000170382. DR GeneID; 10446; -. DR KEGG; hsa:10446; -. DR UCSC; uc001hbe.3; human. DR CTD; 10446; -. DR DisGeNET; 10446; -. DR EuPathDB; HostDB:ENSG00000170382.11; -. DR GeneCards; LRRN2; -. DR H-InvDB; HIX0001502; -. DR HGNC; HGNC:16914; LRRN2. DR HPA; HPA029124; -. DR MIM; 605492; gene. DR neXtProt; NX_O75325; -. DR OpenTargets; ENSG00000170382; -. DR PharmGKB; PA162394661; -. DR eggNOG; KOG0619; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00940000161204; -. DR HOGENOM; HOG000252914; -. DR HOVERGEN; HBG052361; -. DR InParanoid; O75325; -. DR OMA; TEYWACL; -. DR OrthoDB; 998247at2759; -. DR PhylomeDB; O75325; -. DR TreeFam; TF334360; -. DR ChiTaRS; LRRN2; human. DR GeneWiki; LRRN2; -. DR GenomeRNAi; 10446; -. DR PRO; PR:O75325; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000170382; Expressed in 138 organ(s), highest expression level in anterior cingulate cortex. DR ExpressionAtlas; O75325; baseline and differential. DR Genevisible; O75325; HS. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc. DR GO; GO:0007155; P:cell adhesion; TAS:ProtInc. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR Pfam; PF07679; I-set; 1. DR Pfam; PF13855; LRR_8; 3. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00082; LRRCT; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS51450; LRR; 9. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; KW Immunoglobulin domain; Leucine-rich repeat; Membrane; Polymorphism; KW Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 713 Leucine-rich repeat neuronal protein 2. FT /FTId=PRO_0000014849. FT TOPO_DOM 19 630 Extracellular. {ECO:0000255}. FT TRANSMEM 631 651 Helical. {ECO:0000255}. FT TOPO_DOM 652 713 Cytoplasmic. {ECO:0000255}. FT DOMAIN 20 69 LRRNT. FT REPEAT 70 91 LRR 1. FT REPEAT 94 115 LRR 2. FT REPEAT 118 139 LRR 3. FT REPEAT 142 163 LRR 4. FT REPEAT 166 187 LRR 5. FT REPEAT 190 211 LRR 6. FT REPEAT 214 235 LRR 7. FT REPEAT 238 259 LRR 8. FT REPEAT 262 283 LRR 9. FT REPEAT 286 305 LRR 10. FT REPEAT 311 333 LRR 11. FT REPEAT 336 357 LRR 12. FT DOMAIN 369 422 LRRCT. FT DOMAIN 422 511 Ig-like C2-type. FT CARBOHYD 94 94 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 381 381 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 555 555 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 583 583 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 445 497 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 7 7 P -> L (in dbSNP:rs3789044). FT /FTId=VAR_021921. FT VARIANT 19 19 A -> T (in dbSNP:rs36012907). FT {ECO:0000269|PubMed:12975309}. FT /FTId=VAR_049898. FT VARIANT 518 518 L -> V (in dbSNP:rs3747631). FT /FTId=VAR_021922. FT VARIANT 659 659 V -> A (in dbSNP:rs34771052). FT /FTId=VAR_049899. FT VARIANT 692 692 P -> S (in dbSNP:rs11588857). FT /FTId=VAR_049900. FT CONFLICT 355 355 V -> A (in Ref. 6; AAH34047/AAH68541). FT {ECO:0000305}. FT CONFLICT 474 474 Y -> C (in Ref. 1; AAC39792). FT {ECO:0000305}. FT CONFLICT 676 676 A -> P (in Ref. 6; AAH34047/AAH68541). FT {ECO:0000305}. SQ SEQUENCE 713 AA; 78859 MW; 8B97B131FF61254A CRC64; MRLLVAPLLL AWVAGATAAV PVVPWHVPCP PQCACQIRPW YTPRSSYREA TTVDCNDLFL TAVPPALPAG TQTLLLQSNS IVRVDQSELG YLANLTELDL SQNSFSDARD CDFHALPQLL SLHLEENQLT RLEDHSFAGL ASLQELYLNH NQLYRIAPRA FSGLSNLLRL HLNSNLLRAI DSRWFEMLPN LEILMIGGNK VDAILDMNFR PLANLRSLVL AGMNLREISD YALEGLQSLE SLSFYDNQLA RVPRRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL HQQTVESLPN LQEVGLHGNP IRCDCVIRWA NATGTRVRFI EPQSTLCAEP PDLQRLPVRE VPFREMTDHC LPLISPRSFP PSLQVASGES MVLHCRALAE PEPEIYWVTP AGLRLTPAHA GRRYRVYPEG TLELRRVTAE EAGLYTCVAQ NLVGADTKTV SVVVGRALLQ PGRDEGQGLE LRVQETHPYH ILLSWVTPPN TVSTNLTWSS ASSLRGQGAT ALARLPRGTH SYNITRLLQA TEYWACLQVA FADAHTQLAC VWARTKEATS CHRALGDRPG LIAILALAVL LLAAGLAAHL GTGQPRKGVG GRRPLPPAWA FWGWSAPSVR VVSAPLVLPW NPGRKLPRSS EGETLLPPLS QNS //