ID   UDB11_HUMAN             Reviewed;         529 AA.
AC   O75310; Q3KNV9;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   13-FEB-2019, entry version 149.
DE   RecName: Full=UDP-glucuronosyltransferase 2B11;
DE            Short=UDPGT 2B11;
DE            EC=2.4.1.17;
DE   Flags: Precursor;
GN   Name=UGT2B11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9675083; DOI=10.1006/bbrc.1998.8908;
RA   Beaulieu M., Levesque E., Hum D.W., Belanger A.;
RT   "Isolation and characterization of a human orphan UDP-
RT   glucuronosyltransferase, UGT2B11.";
RL   Biochem. Biophys. Res. Commun. 248:44-50(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: UDPGT is of major importance in the conjugation and
CC       subsequent elimination of potentially toxic xenobiotics and
CC       endogenous compounds.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-
CC       pass membrane protein {ECO:0000305}. Endoplasmic reticulum
CC       membrane {ECO:0000305}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AF016492; AAC27891.1; -; mRNA.
DR   EMBL; BC069441; AAH69441.1; -; mRNA.
DR   EMBL; BC107059; AAI07060.1; -; mRNA.
DR   EMBL; BC107060; AAI07061.1; -; mRNA.
DR   CCDS; CCDS3527.1; -.
DR   PIR; JE0200; JE0200.
DR   RefSeq; NP_001064.1; NM_001073.2.
DR   UniGene; Hs.339811; -.
DR   ProteinModelPortal; O75310; -.
DR   IntAct; O75310; 2.
DR   STRING; 9606.ENSP00000387683; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   iPTMnet; O75310; -.
DR   PhosphoSitePlus; O75310; -.
DR   BioMuta; UGT2B11; -.
DR   jPOST; O75310; -.
DR   PaxDb; O75310; -.
DR   PeptideAtlas; O75310; -.
DR   PRIDE; O75310; -.
DR   ProteomicsDB; 49886; -.
DR   Ensembl; ENST00000446444; ENSP00000387683; ENSG00000213759.
DR   GeneID; 10720; -.
DR   KEGG; hsa:10720; -.
DR   UCSC; uc003heh.5; human.
DR   CTD; 10720; -.
DR   DisGeNET; 10720; -.
DR   EuPathDB; HostDB:ENSG00000213759.8; -.
DR   GeneCards; UGT2B11; -.
DR   HGNC; HGNC:12545; UGT2B11.
DR   HPA; HPA045108; -.
DR   MIM; 603064; gene.
DR   neXtProt; NX_O75310; -.
DR   OpenTargets; ENSG00000213759; -.
DR   PharmGKB; PA37187; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   eggNOG; COG1819; LUCA.
DR   GeneTree; ENSGT00940000165281; -.
DR   HOGENOM; HOG000220831; -.
DR   HOVERGEN; HBG004033; -.
DR   InParanoid; O75310; -.
DR   KO; K00699; -.
DR   OMA; ISPCCEL; -.
DR   OrthoDB; 508327at2759; -.
DR   PhylomeDB; O75310; -.
DR   TreeFam; TF315472; -.
DR   BRENDA; 2.4.1.17; 2681.
DR   Reactome; R-HSA-156588; Glucuronidation.
DR   ChiTaRS; UGT2B11; human.
DR   GenomeRNAi; 10720; -.
DR   PRO; PR:O75310; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000213759; Expressed in 36 organ(s), highest expression level in liver.
DR   Genevisible; O75310; HS.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IDA:UniProtKB.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0008210; P:estrogen metabolic process; IDA:UniProtKB.
DR   GO; GO:0052697; P:xenobiotic glucuronidation; IDA:UniProtKB.
DR   GO; GO:0006805; P:xenobiotic metabolic process; TAS:ProtInc.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Endoplasmic reticulum; Glycoprotein;
KW   Glycosyltransferase; Membrane; Microsome; Reference proteome; Signal;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    529       UDP-glucuronosyltransferase 2B11.
FT                                /FTId=PRO_0000036035.
FT   TRANSMEM    493    513       Helical. {ECO:0000255}.
FT   MOD_RES     135    135       N6-succinyllysine.
FT                                {ECO:0000250|UniProtKB:Q8BWQ1}.
FT   CARBOHYD    315    315       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   529 AA;  61038 MW;  CE4AC3C71CFC2AB4 CRC64;
     MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA
     SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY
     DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI
     ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL
     GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG
     ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN
     DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM
     SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA
     HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD
//