ID   SIM24_HUMAN             Reviewed;         130 AA.
AC   O75264; B9EJF4; Q9P059;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   16-JAN-2019, entry version 97.
DE   RecName: Full=Small integral membrane protein 24;
DE   Flags: Precursor;
GN   Name=SMIM24; Synonyms=C19orf77; ORFNames=HSPC323;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-130.
RC   TISSUE=Umbilical cord blood;
RA   Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L.,
RA   Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.;
RT   "Human partial CDS from CD34+ stem cells.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC33194.1; Type=Erroneous gene model prediction; Note=Wrong choice of frame and superfluous exons were predicted.; Evidence={ECO:0000305};
CC       Sequence=AAF29001.1; Type=Frameshift; Positions=111; Evidence={ECO:0000305};
CC       Sequence=EAW69320.1; Type=Erroneous gene model prediction; Note=Wrong choice of frame and superfluous exons were predicted.; Evidence={ECO:0000305};
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DR   EMBL; AC005551; AAC33194.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH471139; EAW69320.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC146979; AAI46980.1; -; mRNA.
DR   EMBL; BC146984; AAI46985.1; -; mRNA.
DR   EMBL; AF161441; AAF29001.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS45915.1; -.
DR   RefSeq; NP_001129975.1; NM_001136503.1.
DR   UniGene; Hs.130714; -.
DR   ProteinModelPortal; O75264; -.
DR   iPTMnet; O75264; -.
DR   PhosphoSitePlus; O75264; -.
DR   BioMuta; SMIM24; -.
DR   EPD; O75264; -.
DR   jPOST; O75264; -.
DR   MaxQB; O75264; -.
DR   PaxDb; O75264; -.
DR   PeptideAtlas; O75264; -.
DR   PRIDE; O75264; -.
DR   ProteomicsDB; 49874; -.
DR   Ensembl; ENST00000215531; ENSP00000215531; ENSG00000095932.
DR   GeneID; 284422; -.
DR   KEGG; hsa:284422; -.
DR   UCSC; uc010xhk.2; human.
DR   CTD; 284422; -.
DR   EuPathDB; HostDB:ENSG00000095932.6; -.
DR   GeneCards; SMIM24; -.
DR   HGNC; HGNC:37244; SMIM24.
DR   HPA; HPA045046; -.
DR   HPA; HPA056027; -.
DR   neXtProt; NX_O75264; -.
DR   OpenTargets; ENSG00000095932; -.
DR   PharmGKB; PA165393200; -.
DR   eggNOG; ENOG410JGND; Eukaryota.
DR   eggNOG; ENOG41114VW; LUCA.
DR   GeneTree; ENSGT00940000154660; -.
DR   HOGENOM; HOG000090239; -.
DR   InParanoid; O75264; -.
DR   OMA; RIWCSKV; -.
DR   OrthoDB; 1595006at2759; -.
DR   PhylomeDB; O75264; -.
DR   TreeFam; TF328829; -.
DR   GenomeRNAi; 284422; -.
DR   PRO; PR:O75264; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000095932; Expressed in 128 organ(s), highest expression level in caput epididymis.
DR   ExpressionAtlas; O75264; baseline and differential.
DR   Genevisible; O75264; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031627; PDZK1IP1/SMIM24.
DR   PANTHER; PTHR15296; PTHR15296; 1.
DR   Pfam; PF15807; MAP17; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    130       Small integral membrane protein 24.
FT                                /FTId=PRO_0000322598.
FT   TRANSMEM     31     51       Helical. {ECO:0000255}.
FT   CONFLICT     22     22       Q -> A (in Ref. 4; AAF29001).
FT                                {ECO:0000305}.
FT   CONFLICT     66     66       E -> G (in Ref. 4; AAF29001).
FT                                {ECO:0000305}.
SQ   SEQUENCE   130 AA;  14964 MW;  678E332E2A13BCC7 CRC64;
     METLGALLVL EFLLLSPVEA QQATEHRLKP WLVGLAAVVG FLFIVYLVLL ANRLWCSKAR
     AEDEEETTFR MESNLYQDQS EDKREKKEAK EKEEKRKKEK KTAKEGESNL GLDLEEKEPG
     DHERAKSTVM
//