ID LIRB5_HUMAN Reviewed; 590 AA. AC O75023; Q8N760; DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 13-FEB-2019, entry version 146. DE RecName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 5; DE AltName: Full=CD85 antigen-like family member C; DE AltName: Full=Leukocyte immunoglobulin-like receptor 8; DE Short=LIR-8; DE AltName: CD_antigen=CD85c; DE Flags: Precursor; GN Name=LILRB5; Synonyms=LIR8; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Peripheral blood leukocyte; RX PubMed=9548455; RA Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.; RT "A family of human lymphoid and myeloid Ig-like receptors, some of RT which bind to MHC class I molecules."; RL J. Immunol. 159:5192-5196(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Small intestine, and Synovium; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Pancreas, and Spleen; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279. RC TISSUE=Plasma; RX PubMed=16335952; DOI=10.1021/pr0502065; RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., RA Moore R.J., Smith R.D.; RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, RT hydrazide chemistry, and mass spectrometry."; RL J. Proteome Res. 4:2070-2080(2005). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-514, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: May act as receptor for class I MHC antigens. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=O75023-1; Sequence=Displayed; CC Name=2; CC IsoId=O75023-2; Sequence=VSP_008461, VSP_008462; CC Note=No experimental confirmation available.; CC Name=3; CC IsoId=O75023-3; Sequence=VSP_008462; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Detected in a natural killer (NK) cells. CC {ECO:0000269|PubMed:9548455}. CC -!- DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred CC to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). CC This motif is involved in modulation of cellular responses. The CC phosphorylated ITIM motif can bind the SH2 domain of several SH2- CC containing phosphatases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF025534; AAB87668.1; -; mRNA. DR EMBL; AK057072; BAB71361.1; -; mRNA. DR EMBL; AK223296; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AC010492; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC025704; AAH25704.1; -; mRNA. DR CCDS; CCDS12885.1; -. [O75023-1] DR CCDS; CCDS42611.1; -. [O75023-2] DR CCDS; CCDS46176.1; -. [O75023-3] DR RefSeq; NP_001074911.1; NM_001081442.2. [O75023-3] DR RefSeq; NP_001074912.1; NM_001081443.2. [O75023-2] DR RefSeq; NP_001291386.1; NM_001304457.1. DR RefSeq; NP_006831.1; NM_006840.4. [O75023-1] DR UniGene; Hs.655338; -. DR ProteinModelPortal; O75023; -. DR SMR; O75023; -. DR BioGrid; 116186; 1. DR IntAct; O75023; 1. DR MINT; O75023; -. DR STRING; 9606.ENSP00000406478; -. DR iPTMnet; O75023; -. DR PhosphoSitePlus; O75023; -. DR BioMuta; LILRB5; -. DR jPOST; O75023; -. DR PaxDb; O75023; -. DR PeptideAtlas; O75023; -. DR PRIDE; O75023; -. DR ProteomicsDB; 49699; -. DR ProteomicsDB; 49700; -. [O75023-2] DR ProteomicsDB; 49701; -. [O75023-3] DR DNASU; 10990; -. DR Ensembl; ENST00000316219; ENSP00000320390; ENSG00000105609. DR Ensembl; ENST00000345866; ENSP00000263430; ENSG00000105609. DR Ensembl; ENST00000449561; ENSP00000406478; ENSG00000105609. DR Ensembl; ENST00000610764; ENSP00000479022; ENSG00000277414. [O75023-2] DR Ensembl; ENST00000614318; ENSP00000483649; ENSG00000278437. [O75023-3] DR Ensembl; ENST00000615429; ENSP00000482404; ENSG00000274311. [O75023-2] DR Ensembl; ENST00000615837; ENSP00000478835; ENSG00000277414. [O75023-1] DR Ensembl; ENST00000616618; ENSP00000478912; ENSG00000274311. [O75023-3] DR Ensembl; ENST00000616805; ENSP00000483502; ENSG00000273991. [O75023-1] DR Ensembl; ENST00000617355; ENSP00000483481; ENSG00000274311. [O75023-1] DR Ensembl; ENST00000619608; ENSP00000479413; ENSG00000277414. [O75023-3] DR Ensembl; ENST00000620714; ENSP00000480909; ENSG00000273991. [O75023-2] DR Ensembl; ENST00000621193; ENSP00000482062; ENSG00000278437. [O75023-1] DR Ensembl; ENST00000621867; ENSP00000481263; ENSG00000273991. [O75023-3] DR Ensembl; ENST00000622596; ENSP00000482535; ENSG00000278437. [O75023-2] DR GeneID; 10990; -. DR KEGG; hsa:10990; -. DR UCSC; uc002qex.4; human. [O75023-1] DR CTD; 10990; -. DR EuPathDB; HostDB:ENSG00000105609.16; -. DR GeneCards; LILRB5; -. DR HGNC; HGNC:6609; LILRB5. DR HPA; HPA012069; -. DR MIM; 604814; gene. DR neXtProt; NX_O75023; -. DR PharmGKB; PA30383; -. DR eggNOG; ENOG410IKJD; Eukaryota. DR eggNOG; ENOG41116BR; LUCA. DR HOGENOM; HOG000234395; -. DR HOVERGEN; HBG074353; -. DR InParanoid; O75023; -. DR KO; K06512; -. DR OrthoDB; 1000446at2759; -. DR PhylomeDB; O75023; -. DR TreeFam; TF336644; -. DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. DR GeneWiki; LILRB5; -. DR GenomeRNAi; 10990; -. DR PRO; PR:O75023; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000105609; Expressed in 111 organ(s), highest expression level in tendon. DR Genevisible; O75023; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc. DR GO; GO:0006952; P:defense response; TAS:ProtInc. DR Gene3D; 2.60.40.10; -; 4. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013151; Immunoglobulin. DR Pfam; PF00047; ig; 2. DR Pfam; PF13895; Ig_2; 1. DR SMART; SM00409; IG; 4. DR SMART; SM00408; IGc2; 3. DR SUPFAM; SSF48726; SSF48726; 4. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Adaptive immunity; Alternative splicing; Complete proteome; KW Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; KW Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; KW Repeat; Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 23 {ECO:0000255}. FT CHAIN 24 590 Leukocyte immunoglobulin-like receptor FT subfamily B member 5. FT /FTId=PRO_0000014825. FT TOPO_DOM 24 458 Extracellular. {ECO:0000255}. FT TRANSMEM 459 479 Helical. {ECO:0000255}. FT TOPO_DOM 480 590 Cytoplasmic. {ECO:0000255}. FT DOMAIN 27 116 Ig-like C2-type 1. FT DOMAIN 111 228 Ig-like C2-type 2. FT DOMAIN 224 313 Ig-like C2-type 3. FT DOMAIN 337 418 Ig-like C2-type 4. FT MOTIF 552 557 ITIM motif 1. FT MOTIF 582 587 ITIM motif 2. FT MOD_RES 514 514 Phosphoserine. FT {ECO:0000244|PubMed:24275569}. FT CARBOHYD 139 139 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 279 279 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:16335952}. FT CARBOHYD 339 339 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 49 98 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 144 195 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 244 295 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 344 395 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 119 218 Missing (in isoform 2). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_008461. FT VAR_SEQ 435 435 P -> PA (in isoform 2 and isoform 3). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_008462. FT VARIANT 247 247 D -> G (in dbSNP:rs12975366). FT /FTId=VAR_061316. FT CONFLICT 12 12 G -> W (in Ref. 2; AK223296). FT {ECO:0000305}. FT CONFLICT 255 255 L -> R (in Ref. 2; AK223296). FT {ECO:0000305}. FT CONFLICT 355 355 L -> S (in Ref. 2; BAB71361). FT {ECO:0000305}. SQ SEQUENCE 590 AA; 64126 MW; 8E7AB249F12E44CD CRC64; MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD ARAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH //