ID   LIRA1_HUMAN             Reviewed;         489 AA.
AC   O75019; O75018; Q3MJA6;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   13-FEB-2019, entry version 147.
DE   RecName: Full=Leukocyte immunoglobulin-like receptor subfamily A member 1;
DE   AltName: Full=CD85 antigen-like family member I;
DE   AltName: Full=Leukocyte immunoglobulin-like receptor 6;
DE            Short=LIR-6;
DE   AltName: CD_antigen=CD85i;
DE   Flags: Precursor;
GN   Name=LILRA1; Synonyms=LIR6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP   VARIANTS GLY-12 AND PRO-220.
RC   TISSUE=Peripheral blood leukocyte;
RX   PubMed=9548455;
RA   Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.;
RT   "A family of human lymphoid and myeloid Ig-like receptors, some of
RT   which bind to MHC class I molecules.";
RL   J. Immunol. 159:5192-5196(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as receptor for class I MHC antigens.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=LIR-6a;
CC         IsoId=O75019-1; Sequence=Displayed;
CC       Name=2; Synonyms=LIR-6b;
CC         IsoId=O75019-2; Sequence=VSP_008454;
CC   -!- TISSUE SPECIFICITY: Detected in monocytes and B-cells.
CC       {ECO:0000269|PubMed:9548455}.
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DR   EMBL; AF025529; AAB87663.1; -; mRNA.
DR   EMBL; AF025530; AAB87664.1; -; mRNA.
DR   EMBL; BC101514; AAI01515.1; -; mRNA.
DR   CCDS; CCDS12901.1; -. [O75019-1]
DR   CCDS; CCDS62802.1; -. [O75019-2]
DR   RefSeq; NP_001265247.1; NM_001278318.1. [O75019-2]
DR   RefSeq; NP_001265248.1; NM_001278319.1.
DR   RefSeq; NP_006854.1; NM_006863.3. [O75019-1]
DR   UniGene; Hs.710507; -.
DR   ProteinModelPortal; O75019; -.
DR   SMR; O75019; -.
DR   BioGrid; 116214; 1.
DR   STRING; 9606.ENSP00000251372; -.
DR   iPTMnet; O75019; -.
DR   PhosphoSitePlus; O75019; -.
DR   BioMuta; LILRA1; -.
DR   PaxDb; O75019; -.
DR   PeptideAtlas; O75019; -.
DR   PRIDE; O75019; -.
DR   ProteomicsDB; 49694; -.
DR   ProteomicsDB; 49695; -. [O75019-2]
DR   Ensembl; ENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
DR   Ensembl; ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
DR   Ensembl; ENST00000617170; ENSP00000477637; ENSG00000275525. [O75019-1]
DR   Ensembl; ENST00000620606; ENSP00000478666; ENSG00000275525. [O75019-2]
DR   Ensembl; ENST00000628480; ENSP00000487229; ENSG00000277398. [O75019-2]
DR   Ensembl; ENST00000631007; ENSP00000487011; ENSG00000274935. [O75019-2]
DR   GeneID; 11024; -.
DR   KEGG; hsa:11024; -.
DR   UCSC; uc002qgh.4; human. [O75019-1]
DR   CTD; 11024; -.
DR   DisGeNET; 11024; -.
DR   EuPathDB; HostDB:ENSG00000104974.10; -.
DR   GeneCards; LILRA1; -.
DR   HGNC; HGNC:6602; LILRA1.
DR   MIM; 604810; gene.
DR   neXtProt; NX_O75019; -.
DR   OpenTargets; ENSG00000104974; -.
DR   PharmGKB; PA30376; -.
DR   eggNOG; ENOG410IKJD; Eukaryota.
DR   eggNOG; ENOG41116BR; LUCA.
DR   GeneTree; ENSGT00940000153160; -.
DR   HOGENOM; HOG000234395; -.
DR   HOVERGEN; HBG074353; -.
DR   InParanoid; O75019; -.
DR   KO; K06512; -.
DR   OMA; WGRQADF; -.
DR   OrthoDB; 1000446at2759; -.
DR   PhylomeDB; O75019; -.
DR   TreeFam; TF336644; -.
DR   Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   ChiTaRS; LILRA1; human.
DR   GenomeRNAi; 11024; -.
DR   PRO; PR:O75019; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000104974; Expressed in 102 organ(s), highest expression level in leukocyte.
DR   Genevisible; O75019; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0003823; F:antigen binding; TAS:ProtInc.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0006952; P:defense response; TAS:ProtInc.
DR   GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR016332; A1B_glyco/leuk_Ig-like_rcpt.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF13895; Ig_2; 2.
DR   PIRSF; PIRSF001979; Alpha_1B_glycoprot_prd; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Alternative splicing; Complete proteome;
KW   Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain;
KW   Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     16       {ECO:0000255}.
FT   CHAIN        17    489       Leukocyte immunoglobulin-like receptor
FT                                subfamily A member 1.
FT                                /FTId=PRO_0000014816.
FT   TOPO_DOM     17    461       Extracellular. {ECO:0000255}.
FT   TRANSMEM    462    482       Helical. {ECO:0000255}.
FT   TOPO_DOM    483    489       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       27    116       Ig-like C2-type 1.
FT   DOMAIN      119    224       Ig-like C2-type 2.
FT   DOMAIN      226    315       Ig-like C2-type 3.
FT   DOMAIN      326    415       Ig-like C2-type 4.
FT   CARBOHYD    140    140       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    281    281       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    302    302       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    341    341       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    431    431       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    448    448       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     49     98       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   DISULFID    145    197       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   DISULFID    157    167       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   DISULFID    246    297       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   DISULFID    346    397       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   VAR_SEQ     221    420       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:9548455}.
FT                                /FTId=VSP_008454.
FT   VARIANT      12     12       R -> G (in dbSNP:rs1974982).
FT                                {ECO:0000269|PubMed:9548455}.
FT                                /FTId=VAR_059396.
FT   VARIANT     153    153       S -> G (in dbSNP:rs10417589).
FT                                /FTId=VAR_049886.
FT   VARIANT     220    220       L -> P (in dbSNP:rs373854).
FT                                {ECO:0000269|PubMed:9548455}.
FT                                /FTId=VAR_049887.
FT   CONFLICT      5      5       V -> L (in Ref. 1; AAB87663).
FT                                {ECO:0000305}.
SQ   SEQUENCE   489 AA;  53275 MW;  44469FD4884EA068 CRC64;
     MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ GILETQEYRL
     YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY GSHTAGWSEP SDPLELVVTG
     AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA FGSFILCKEG EDEHPQCLNS QPRTHGWSRA
     IFSVGPVSPS RRWSYRCYAY DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE
     SLTLQCVSDV SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA
     YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG PFHTFLLTKA
     GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS LSSNPYLLSH PSDSLELMVS
     GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT ASHPQDYTVE NLIRMGIAGL VLVVLGILLF
     EAQHSQRSL
//