ID   PSPN_HUMAN              Reviewed;         156 AA.
AC   O60542;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   13-FEB-2019, entry version 136.
DE   RecName: Full=Persephin;
DE            Short=PSP;
DE   Flags: Precursor;
GN   Name=PSPN;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9491986; DOI=10.1016/S0896-6273(00)80453-5;
RA   Milbrandt J., de Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L.,
RA   Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T.,
RA   Simburger K.S., Golden J.P., Davies J.A., Vejsada R., Kato A.C.,
RA   Hynes M., Sherman D., Nishimura M., Wang L.-C., Vandlen R., Moffat B.,
RA   Klein R.D., Poulsen K., Gray C., Garces A., Henderson C.E.,
RA   Phillips H.S., Johnson E.M.;
RT   "Persephin, a novel neurotrophic factor related to GDNF and
RT   neurturin.";
RL   Neuron 20:245-253(1998).
CC   -!- FUNCTION: Exhibits neurotrophic activity on mesencephalic
CC       dopaminergic and motor neurons.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF040962; AAC39640.1; -; mRNA.
DR   CCDS; CCDS12164.1; -.
DR   RefSeq; NP_004149.1; NM_004158.3.
DR   UniGene; Hs.248159; -.
DR   ProteinModelPortal; O60542; -.
DR   SMR; O60542; -.
DR   BioGrid; 111607; 2.
DR   STRING; 9606.ENSP00000245810; -.
DR   iPTMnet; O60542; -.
DR   PhosphoSitePlus; O60542; -.
DR   BioMuta; PSPN; -.
DR   PaxDb; O60542; -.
DR   PRIDE; O60542; -.
DR   ProteomicsDB; 49463; -.
DR   DNASU; 5623; -.
DR   Ensembl; ENST00000245810; ENSP00000245810; ENSG00000125650.
DR   GeneID; 5623; -.
DR   KEGG; hsa:5623; -.
DR   UCSC; uc010xja.2; human.
DR   CTD; 5623; -.
DR   DisGeNET; 5623; -.
DR   EuPathDB; HostDB:ENSG00000125650.4; -.
DR   GeneCards; PSPN; -.
DR   HGNC; HGNC:9579; PSPN.
DR   HPA; CAB025366; -.
DR   MIM; 602921; gene.
DR   neXtProt; NX_O60542; -.
DR   OpenTargets; ENSG00000125650; -.
DR   PharmGKB; PA33930; -.
DR   eggNOG; ENOG410J061; Eukaryota.
DR   eggNOG; ENOG4111Y7H; LUCA.
DR   GeneTree; ENSGT00940000154425; -.
DR   HOGENOM; HOG000220877; -.
DR   HOVERGEN; HBG008316; -.
DR   InParanoid; O60542; -.
DR   OMA; TFRYCAG; -.
DR   OrthoDB; 1373819at2759; -.
DR   PhylomeDB; O60542; -.
DR   TreeFam; TF332366; -.
DR   Reactome; R-HSA-419037; NCAM1 interactions.
DR   Reactome; R-HSA-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-HSA-8853659; RET signaling.
DR   SIGNOR; O60542; -.
DR   GenomeRNAi; 5623; -.
DR   PRO; PR:O60542; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000125650; Expressed in 103 organ(s), highest expression level in vagina.
DR   ExpressionAtlas; O60542; baseline and differential.
DR   Genevisible; O60542; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
DR   GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR   GO; GO:0000165; P:MAPK cascade; TAS:Reactome.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    156       Persephin.
FT                                /FTId=PRO_0000034014.
FT   DISULFID     66    124       {ECO:0000250}.
FT   DISULFID     93    152       {ECO:0000250}.
FT   DISULFID     97    154       {ECO:0000250}.
FT   DISULFID    123    123       Interchain. {ECO:0000250}.
SQ   SEQUENCE   156 AA;  16600 MW;  6547751653A7044A CRC64;
     MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG THRPLARLRR
     ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG
     GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
//