ID   MPZL2_HUMAN             Reviewed;         215 AA.
AC   O60487; A8K2R1;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   13-FEB-2019, entry version 156.
DE   RecName: Full=Myelin protein zero-like protein 2;
DE   AltName: Full=Epithelial V-like antigen 1;
DE   Flags: Precursor;
GN   Name=MPZL2; Synonyms=EVA, EVA1; ORFNames=UNQ606/PRO1192;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver, and Spleen;
RX   PubMed=9585423; DOI=10.1083/jcb.141.4.1061;
RA   Guttinger M., Sutti F., Panigada M., Porcellini S., Merati B.,
RA   Mariani M., Teesalu T., Consalez G.G., Grassi F.;
RT   "Epithelial V-like antigen (EVA), a novel member of the immunoglobulin
RT   superfamily, expressed in embryonic epithelia with a potential role as
RT   homotypic adhesion molecule in thymus histogenesis.";
RL   J. Cell Biol. 141:1061-1071(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Endometrial tumor;
RA   Davenport J.W., Neale G.A.M., Goorha R.M.;
RT   "Identification of putative target genes involved in LMO2-induced
RT   leukemogenesis.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Squamous cell carcinoma;
RA   Pietas A., Petersen I., Schluens K., Petersen S.;
RT   "Human EVA1 gene which is downregulated in lung carcinoma cells.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-39.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of
RT   multiple enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
CC   -!- FUNCTION: Mediates homophilic cell-cell adhesion.
CC   -!- INTERACTION:
CC       Q6UWV2:MPZL3; NbExp=3; IntAct=EBI-3906725, EBI-4314854;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in thymocytes and thymic stromal
CC       cells; expression elevated in some T-cell leukemias.
CC   -!- SIMILARITY: Belongs to the myelin P0 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF030455; AAC39762.1; -; mRNA.
DR   EMBL; AF275945; AAF87240.1; -; mRNA.
DR   EMBL; AF304447; AAG23183.1; -; mRNA.
DR   EMBL; AY359061; AAQ89420.1; -; mRNA.
DR   EMBL; AK290326; BAF83015.1; -; mRNA.
DR   EMBL; CH471065; EAW67358.1; -; Genomic_DNA.
DR   EMBL; BC017774; AAH17774.1; -; mRNA.
DR   CCDS; CCDS8393.1; -.
DR   RefSeq; NP_005788.1; NM_005797.3.
DR   RefSeq; NP_658911.1; NM_144765.2.
DR   UniGene; Hs.116651; -.
DR   ProteinModelPortal; O60487; -.
DR   BioGrid; 115500; 9.
DR   IntAct; O60487; 4.
DR   STRING; 9606.ENSP00000278937; -.
DR   GlyConnect; 1528; -.
DR   iPTMnet; O60487; -.
DR   PhosphoSitePlus; O60487; -.
DR   BioMuta; MPZL2; -.
DR   EPD; O60487; -.
DR   jPOST; O60487; -.
DR   MaxQB; O60487; -.
DR   PaxDb; O60487; -.
DR   PeptideAtlas; O60487; -.
DR   PRIDE; O60487; -.
DR   ProteomicsDB; 49425; -.
DR   TopDownProteomics; O60487; -.
DR   DNASU; 10205; -.
DR   Ensembl; ENST00000278937; ENSP00000278937; ENSG00000149573.
DR   Ensembl; ENST00000438295; ENSP00000408362; ENSG00000149573.
DR   GeneID; 10205; -.
DR   KEGG; hsa:10205; -.
DR   UCSC; uc001psn.4; human.
DR   CTD; 10205; -.
DR   DisGeNET; 10205; -.
DR   EuPathDB; HostDB:ENSG00000149573.8; -.
DR   GeneCards; MPZL2; -.
DR   HGNC; HGNC:3496; MPZL2.
DR   HPA; HPA060740; -.
DR   MIM; 604873; gene.
DR   neXtProt; NX_O60487; -.
DR   OpenTargets; ENSG00000149573; -.
DR   Orphanet; 90636; Autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR   PharmGKB; PA162396145; -.
DR   eggNOG; ENOG410IU94; Eukaryota.
DR   eggNOG; ENOG410YKVV; LUCA.
DR   GeneTree; ENSGT00940000157977; -.
DR   HOGENOM; HOG000232144; -.
DR   HOVERGEN; HBG107197; -.
DR   InParanoid; O60487; -.
DR   OMA; VVQTVRF; -.
DR   OrthoDB; 1214335at2759; -.
DR   PhylomeDB; O60487; -.
DR   TreeFam; TF331728; -.
DR   GenomeRNAi; 10205; -.
DR   PRO; PR:O60487; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149573; Expressed in 183 organ(s), highest expression level in gingival epithelium.
DR   ExpressionAtlas; O60487; baseline and differential.
DR   Genevisible; O60487; HS.
DR   GO; GO:0005856; C:cytoskeleton; TAS:ProtInc.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; TAS:ProtInc.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR029863; MPZL2.
DR   InterPro; IPR000920; Myelin_P0-rel.
DR   PANTHER; PTHR13869; PTHR13869; 1.
DR   PANTHER; PTHR13869:SF21; PTHR13869:SF21; 1.
DR   Pfam; PF07686; V-set; 1.
DR   PRINTS; PR00213; MYELINP0.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27    215       Myelin protein zero-like protein 2.
FT                                /FTId=PRO_0000014756.
FT   TOPO_DOM     27    154       Extracellular. {ECO:0000255}.
FT   TRANSMEM    155    175       Helical. {ECO:0000255}.
FT   TOPO_DOM    176    215       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       27    141       Ig-like V-type.
FT   CARBOHYD     39     39       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:19159218}.
FT   CARBOHYD    118    118       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     47    123       {ECO:0000255|PROSITE-ProRule:PRU00114}.
SQ   SEQUENCE   215 AA;  24484 MW;  9D19EBA798B5815A CRC64;
     MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS SFAPVGDALT
     VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN PERYDASILL WKLQFDDNGT
     YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE IHFLALAIGS ACALMIIIVI VVVLFQHYRK
     KRWAERAHKV VEIKSKEEER LNQEKKVSVY LEDTD
//