ID   PCDGC_HUMAN             Reviewed;         932 AA.
AC   O60330; O15100; Q6UW70; Q9Y5D7;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JAN-2019, entry version 153.
DE   RecName: Full=Protocadherin gamma-A12;
DE            Short=PCDH-gamma-A12;
DE   AltName: Full=Cadherin-21;
DE   AltName: Full=Fibroblast cadherin-3;
DE   Flags: Precursor;
GN   Name=PCDHGA12; Synonyms=CDH21, FIB3, KIAA0588; ORFNames=UNQ371/PRO707;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=10380929; DOI=10.1016/S0092-8674(00)80789-8;
RA   Wu Q., Maniatis T.;
RT   "A striking organization of a large family of human neural cadherin-
RT   like cell adhesion genes.";
RL   Cell 97:779-790(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA   Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA   Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. IX.
RT   The complete sequences of 100 new cDNA clones from brain which can
RT   code for large proteins in vitro.";
RL   DNA Res. 5:31-39(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-808.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 311-444.
RX   PubMed=9199196; DOI=10.1006/bbrc.1997.6707;
RA   Matsuyoshi N., Imamura S.;
RT   "Multiple cadherins are expressed in human fibroblasts.";
RL   Biochem. Biophys. Res. Commun. 235:355-358(1997).
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May
CC       be involved in the establishment and maintenance of specific
CC       neuronal connections in the brain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
CC       type I membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O60330-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=O60330-2; Sequence=VSP_008682, VSP_008683;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAQ89305.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC       Sequence=BAA25514.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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DR   EMBL; AF152321; AAD43715.1; -; mRNA.
DR   EMBL; AF152506; AAD43767.1; -; mRNA.
DR   EMBL; AB011160; BAA25514.2; ALT_INIT; mRNA.
DR   EMBL; AY358946; AAQ89305.1; ALT_SEQ; mRNA.
DR   EMBL; AB000897; BAA21135.1; -; mRNA.
DR   CCDS; CCDS4260.1; -. [O60330-1]
DR   CCDS; CCDS75346.1; -. [O60330-2]
DR   PIR; PC4299; PC4299.
DR   RefSeq; NP_003726.1; NM_003735.2. [O60330-1]
DR   RefSeq; NP_115265.1; NM_032094.1. [O60330-2]
DR   UniGene; Hs.368160; -.
DR   ProteinModelPortal; O60330; -.
DR   SMR; O60330; -.
DR   BioGrid; 117494; 3.
DR   iPTMnet; O60330; -.
DR   PhosphoSitePlus; O60330; -.
DR   BioMuta; PCDHGA12; -.
DR   EPD; O60330; -.
DR   jPOST; O60330; -.
DR   MaxQB; O60330; -.
DR   PaxDb; O60330; -.
DR   PeptideAtlas; O60330; -.
DR   PRIDE; O60330; -.
DR   ProteomicsDB; 49346; -.
DR   ProteomicsDB; 49347; -. [O60330-2]
DR   Ensembl; ENST00000252085; ENSP00000252085; ENSG00000253159. [O60330-1]
DR   Ensembl; ENST00000613314; ENSP00000481438; ENSG00000253159. [O60330-2]
DR   GeneID; 26025; -.
DR   KEGG; hsa:26025; -.
DR   UCSC; uc003lkt.3; human. [O60330-1]
DR   CTD; 26025; -.
DR   EuPathDB; HostDB:ENSG00000253159.2; -.
DR   GeneCards; PCDHGA12; -.
DR   HGNC; HGNC:8699; PCDHGA12.
DR   HPA; HPA008755; -.
DR   HPA; HPA010580; -.
DR   MIM; 603059; gene.
DR   MIM; 604968; gene.
DR   neXtProt; NX_O60330; -.
DR   OpenTargets; ENSG00000253159; -.
DR   PharmGKB; PA33047; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000164062; -.
DR   HOGENOM; HOG000220892; -.
DR   HOVERGEN; HBG054878; -.
DR   InParanoid; O60330; -.
DR   KO; K16495; -.
DR   OMA; STQIRYS; -.
DR   OrthoDB; 213724at2759; -.
DR   PhylomeDB; O60330; -.
DR   TreeFam; TF332299; -.
DR   GeneWiki; PCDHGA12; -.
DR   GenomeRNAi; 26025; -.
DR   PRO; PR:O60330; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000253159; Expressed in 90 organ(s), highest expression level in putamen.
DR   Genevisible; O60330; HS.
DR   GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR031904; Cadherin_CBD.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   Pfam; PF15974; Cadherin_tail; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 5.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Calcium; Cell adhesion; Cell membrane;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     29       {ECO:0000255}.
FT   CHAIN        30    932       Protocadherin gamma-A12.
FT                                /FTId=PRO_0000003970.
FT   TOPO_DOM     30    692       Extracellular. {ECO:0000255}.
FT   TRANSMEM    693    713       Helical. {ECO:0000255}.
FT   TOPO_DOM    714    932       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       30    133       Cadherin 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      134    242       Cadherin 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      243    347       Cadherin 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      348    452       Cadherin 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      453    562       Cadherin 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   DOMAIN      570    683       Cadherin 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00043}.
FT   CARBOHYD    265    265       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    419    419       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    545    545       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ     809    820       QAPPNTDWRFSQ -> VSLYQIFFLFFF (in isoform
FT                                2). {ECO:0000303|PubMed:10380929}.
FT                                /FTId=VSP_008682.
FT   VAR_SEQ     821    932       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:10380929}.
FT                                /FTId=VSP_008683.
FT   CONFLICT    331    331       A -> P (in Ref. 4; BAA21135).
FT                                {ECO:0000305}.
SQ   SEQUENCE   932 AA;  100955 MW;  8BDA90084785D746 CRC64;
     MIPARLHRDY KGLVLLGILL GTLWETGCTQ IRYSVPEELE KGSRVGDISR DLGLEPRELA
     ERGVRIIPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI KCQLNLDILM EDKVKIYGVE
     VEVRDINDNA PYFRESELEI KISENAATEM RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL
     IVQNGADGSK YPELVLKRAL DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP
     AFAQPEYRAS VPENLALGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT
     ISTIGELDHE ESGFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT SLASSVPENS
     PRGTLIALLN VNDQDSEENG QVICFIQGNL PFKLEKSYGN YYSLVTDIVL DREQVPSYNI
     TVTATDRGTP PLSTETHISL NVADTNDNPP VFPQASYSAY IPENNPRGVS LVSVTAHDPD
     CEENAQITYS LAENTIQGAS LSSYVSINSD TGVLYALSSF DYEQFRDLQV KVMARDNGHP
     PLSSNVSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
     NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL
     TVAVADSIPQ VLADLGSLES PANSETSDLT LYLVVAVAAV SCVFLAFVIL LLALRLRRWH
     KSRLLQASGG GLTGAPASHF VGVDGVQAFL QTYSHEVSLT TDSRKSHLIF PQPNYADMLV
     SQESFEKSEP LLLSGDSVFS KDSHGLIEQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN
     NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
     NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
//