ID   L37A3_HUMAN             Reviewed;        1634 AA.
AC   O60309; Q49A01; Q49A80; Q8NB33;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   13-FEB-2019, entry version 136.
DE   RecName: Full=Leucine-rich repeat-containing protein 37A3;
DE   Flags: Precursor;
GN   Name=LRRC37A3; Synonyms=KIAA0563;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA   Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA   Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. IX.
RT   The complete sequences of 100 new cDNA clones from brain which can
RT   code for large proteins in vitro.";
RL   DNA Res. 5:31-39(1998).
RN   [2]
RP   SEQUENCE REVISION.
RA   Ohara O., Nagase T., Kikuno R., Ishikawa K.;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1019-1634.
RC   TISSUE=Fetal brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC37A family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA25489.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AB011135; BAA25489.3; ALT_INIT; mRNA.
DR   EMBL; BC043145; AAH43145.1; -; mRNA.
DR   EMBL; AK091625; BAC03710.1; ALT_INIT; mRNA.
DR   CCDS; CCDS32708.1; -.
DR   RefSeq; NP_955372.2; NM_199340.3.
DR   UniGene; Hs.551962; -.
DR   UniGene; Hs.744157; -.
DR   UniGene; Hs.744758; -.
DR   ProteinModelPortal; O60309; -.
DR   STRING; 9606.ENSP00000325713; -.
DR   iPTMnet; O60309; -.
DR   PhosphoSitePlus; O60309; -.
DR   BioMuta; LRRC37A3; -.
DR   EPD; O60309; -.
DR   jPOST; O60309; -.
DR   PaxDb; O60309; -.
DR   PeptideAtlas; O60309; -.
DR   PRIDE; O60309; -.
DR   ProteomicsDB; 49338; -.
DR   Ensembl; ENST00000319651; ENSP00000325713; ENSG00000176809.
DR   Ensembl; ENST00000584306; ENSP00000464535; ENSG00000176809.
DR   GeneID; 374819; -.
DR   KEGG; hsa:374819; -.
DR   UCSC; uc002jey.3; human.
DR   CTD; 374819; -.
DR   DisGeNET; 374819; -.
DR   EuPathDB; HostDB:ENSG00000176809.10; -.
DR   GeneCards; LRRC37A3; -.
DR   H-InvDB; HIX0026017; -.
DR   H-InvDB; HIX0027304; -.
DR   H-InvDB; HIX0027323; -.
DR   HGNC; HGNC:32427; LRRC37A3.
DR   HPA; HPA042121; -.
DR   HPA; HPA042701; -.
DR   HPA; HPA043056; -.
DR   HPA; HPA045090; -.
DR   MIM; 616557; gene.
DR   neXtProt; NX_O60309; -.
DR   OpenTargets; ENSG00000176809; -.
DR   PharmGKB; PA162394563; -.
DR   eggNOG; ENOG410IJNR; Eukaryota.
DR   eggNOG; ENOG410YV94; LUCA.
DR   GeneTree; ENSGT00530000063282; -.
DR   HOGENOM; HOG000113269; -.
DR   HOVERGEN; HBG100009; -.
DR   InParanoid; O60309; -.
DR   OMA; PENTINQ; -.
DR   OrthoDB; 181606at2759; -.
DR   PhylomeDB; O60309; -.
DR   TreeFam; TF341959; -.
DR   ChiTaRS; LRRC37A3; human.
DR   GenomeRNAi; 374819; -.
DR   PRO; PR:O60309; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000176809; Expressed in 179 organ(s), highest expression level in testis.
DR   ExpressionAtlas; O60309; baseline and differential.
DR   Genevisible; O60309; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR015753; LRRC37.
DR   InterPro; IPR032754; LRRC37_N.
DR   InterPro; IPR029423; LRRC37AB_C.
DR   PANTHER; PTHR23045; PTHR23045; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF15779; LRRC37; 6.
DR   Pfam; PF14914; LRRC37AB_C; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Polymorphism; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     35       {ECO:0000255}.
FT   CHAIN        36   1634       Leucine-rich repeat-containing protein
FT                                37A3.
FT                                /FTId=PRO_0000076244.
FT   TOPO_DOM     36   1581       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1582   1602       Helical. {ECO:0000255}.
FT   TOPO_DOM   1603   1634       Cytoplasmic. {ECO:0000255}.
FT   REPEAT      137    160       LRR 1.
FT   REPEAT      230    253       LRR 2.
FT   REPEAT      267    290       LRR 3.
FT   REPEAT      864    887       LRR 4.
FT   REPEAT      888    911       LRR 5.
FT   REPEAT      912    935       LRR 6.
FT   REPEAT      937    959       LRR 7.
FT   REPEAT      963    987       LRR 8.
FT   REPEAT     1002   1027       LRR 9.
FT   REPEAT     1124   1146       LRR 10.
FT   REPEAT     1151   1176       LRR 11.
FT   REPEAT     1359   1384       LRR 12.
FT   CARBOHYD    296    296       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1079   1079       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VARIANT    1215   1215       K -> E (in dbSNP:rs9893710).
FT                                /FTId=VAR_051088.
FT   VARIANT    1590   1590       G -> A (in dbSNP:rs28532307).
FT                                /FTId=VAR_061672.
FT   CONFLICT     51     51       S -> P (in Ref. 3; AAH43145).
FT                                {ECO:0000305}.
FT   CONFLICT   1086   1086       I -> T (in Ref. 3; AAH43145).
FT                                {ECO:0000305}.
FT   CONFLICT   1417   1417       T -> A (in Ref. 3; AAH43145).
FT                                {ECO:0000305}.
FT   CONFLICT   1419   1419       Y -> H (in Ref. 4; BAC03710).
FT                                {ECO:0000305}.
FT   CONFLICT   1619   1619       S -> P (in Ref. 4; BAC03710).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1634 AA;  180621 MW;  84C8F93290B29EB1 CRC64;
     MTSAQCPALA CVMSPLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPEPW
     SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGELP
     LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGIIHQL STPQSQKQTL
     QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
     EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
     PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
     QQPVQPSESS REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
     IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
     QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
     QATVQPLDLG FTITPESMTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
     PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
     ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
     LDLELTITTK PTTEVKPSPT TEETSTQLPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV
     QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
     LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
     LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
     HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIV
     PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
     TSTELIIEPE EPSDSSGINL SGFGSEQLDT NDESDVTSTL SYILPYFSAV NLDVKSLLLP
     FIKLPTTGNS LAKIQTVGKN RQRLNRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENT
     AEEKRLGSPA PRELKQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGAPSTSS
     PAKALPQVRD RWKDLTHAIS ILESAKARVT NMKTSKPIVH SRKKYRFHKT RSRMTHRTPK
     VKKSPKVRKK SYLSRLMLSN RLPFSAAKSL INSPSQGAFS SLRDLSPQEN PFLEVSAPSE
     HFIENNNTKD TTARNAFEEN VFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ
     TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSVIPNNNV RRLIAHVIRT
     LKMDCSGAHV QVTCAKLVSR TGHLMKLLSG QQEVKASKIE WDTDQWKTEN YINESTEAQS
     EQKEKSLEFT KELPGYGYTK KLILALIVTG ILTILIILLC LIEICCHRRS LQEDEEGFSR
     DSEAPTEEES EALP
//