ID   SUSD5_HUMAN             Reviewed;         629 AA.
AC   O60279;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 3.
DT   13-FEB-2019, entry version 120.
DE   RecName: Full=Sushi domain-containing protein 5;
DE   Flags: Precursor;
GN   Name=SUSD5; Synonyms=KIAA0527;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-40 AND
RP   ASP-378.
RC   TISSUE=Brain;
RX   PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA   Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA   Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. IX.
RT   The complete sequences of 100 new cDNA clones from brain which can
RT   code for large proteins in vitro.";
RL   DNA Res. 5:31-39(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA25453.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB011099; BAA25453.1; ALT_INIT; mRNA.
DR   EMBL; AC123900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46787.1; -.
DR   PIR; T00073; T00073.
DR   RefSeq; NP_056366.1; NM_015551.1.
DR   UniGene; Hs.196647; -.
DR   ProteinModelPortal; O60279; -.
DR   SMR; O60279; -.
DR   BioGrid; 117498; 10.
DR   iPTMnet; O60279; -.
DR   PhosphoSitePlus; O60279; -.
DR   SwissPalm; O60279; -.
DR   BioMuta; SUSD5; -.
DR   EPD; O60279; -.
DR   MaxQB; O60279; -.
DR   PaxDb; O60279; -.
DR   PeptideAtlas; O60279; -.
DR   PRIDE; O60279; -.
DR   ProteomicsDB; 49308; -.
DR   Ensembl; ENST00000309558; ENSP00000308727; ENSG00000173705.
DR   GeneID; 26032; -.
DR   KEGG; hsa:26032; -.
DR   UCSC; uc003cfo.2; human.
DR   CTD; 26032; -.
DR   EuPathDB; HostDB:ENSG00000173705.8; -.
DR   GeneCards; SUSD5; -.
DR   H-InvDB; HIX0003154; -.
DR   HGNC; HGNC:29061; SUSD5.
DR   HPA; HPA052788; -.
DR   neXtProt; NX_O60279; -.
DR   OpenTargets; ENSG00000173705; -.
DR   PharmGKB; PA143485627; -.
DR   eggNOG; ENOG410IFAC; Eukaryota.
DR   eggNOG; ENOG410YBQZ; LUCA.
DR   GeneTree; ENSGT00390000009163; -.
DR   HOGENOM; HOG000154451; -.
DR   HOVERGEN; HBG108521; -.
DR   InParanoid; O60279; -.
DR   OMA; AETFHKP; -.
DR   OrthoDB; 393645at2759; -.
DR   PhylomeDB; O60279; -.
DR   TreeFam; TF336259; -.
DR   ChiTaRS; SUSD5; human.
DR   GenomeRNAi; 26032; -.
DR   PRO; PR:O60279; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000173705; Expressed in 173 organ(s), highest expression level in descending thoracic aorta.
DR   ExpressionAtlas; O60279; baseline and differential.
DR   Genevisible; O60279; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IBA:GO_Central.
DR   CDD; cd00033; CCP; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR000538; Link_dom.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00193; Xlink; 1.
DR   SMART; SM00445; LINK; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   SUPFAM; SSF57535; SSF57535; 1.
DR   PROSITE; PS50963; LINK_2; 1.
DR   PROSITE; PS50923; SUSHI; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Disulfide bond; Membrane; Polymorphism;
KW   Reference proteome; Signal; Sushi; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     35       {ECO:0000255}.
FT   CHAIN        36    629       Sushi domain-containing protein 5.
FT                                /FTId=PRO_0000274247.
FT   TOPO_DOM     36    574       Extracellular. {ECO:0000255}.
FT   TRANSMEM    575    595       Helical. {ECO:0000255}.
FT   TOPO_DOM    596    629       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       39    134       Link. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00323}.
FT   DOMAIN      138    199       Sushi. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00302}.
FT   DISULFID     61    132       {ECO:0000250}.
FT   DISULFID    140    184       {ECO:0000250}.
FT   DISULFID    167    197       {ECO:0000250}.
FT   VARIANT      40     40       F -> L (in dbSNP:rs9637517).
FT                                {ECO:0000269|PubMed:9628581}.
FT                                /FTId=VAR_051391.
FT   VARIANT      52     52       L -> F (in dbSNP:rs9637517).
FT                                /FTId=VAR_030217.
FT   VARIANT     216    216       R -> K (in dbSNP:rs9872477).
FT                                /FTId=VAR_051392.
FT   VARIANT     228    228       R -> K (in dbSNP:rs9872477).
FT                                /FTId=VAR_030218.
FT   VARIANT     378    378       E -> D (in dbSNP:rs6810039).
FT                                {ECO:0000269|PubMed:9628581}.
FT                                /FTId=VAR_051393.
FT   CONFLICT    272    272       L -> S (in Ref. 1; BAA25453).
FT                                {ECO:0000305}.
SQ   SEQUENCE   629 AA;  68021 MW;  51CB3C12D932FD9E CRC64;
     MTAEGPSPPA RWHRRLPGLW AAALLLLGLP RLSVRADGKF FVLESQNGSQ GLQLEAARLS
     CKSRGAHLAS ADELRRVVQD CSFAVCTTGW LADGTLGTTV CSKGSGEQQI MRAVDVRIES
     NPVPGGTYSA LCIKDEEKPC GDPPSFPHTI LQGRTGLEMG DELLYVCAPG HIMGHRETAF
     TLLCNSCGEW YGLVQACGKD EAEAHIDYED NFPDDRSVSF RELMEDSRTE ADEDRGQGDS
     SEEAPKQDRL VSISVGRENI ARDKVFVPTT GLPGAGSSVP ADSPGSRLLQ KHLFWFPAEA
     FHKPGLEKEV DDDTKKQFSA GDNHSGVKLV PGEPETKVIY GNTDGPSGPF VGKNDSKAGD
     PVVSSSDESW LDGYPVTEGA WRKTEAEEEE DGDRGDGSVG LDENVLVTPD QPILVEVKKP
     KSSTLTPSEG MTHSSVLPSQ MLDVEALALR PVNASETEGI GDGDLTKYQS TLPWRFITEE
     SPMATLSYEL TSSTLEILTV NTVKQTPNHI PSTIMATTQP PVETTVPEIQ DSFPYLLSED
     FFGQEGPGPG ASEELHPTLE SCVGDGCPGL SRGPVIATIV TVLCLLLLLA GVGMVWGYRK
     CQHKSSVYKL NVGQRQARHY HQQIEMEKV
//