ID CXL13_HUMAN Reviewed; 109 AA. AC O43927; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1998, sequence version 1. DT 13-FEB-2019, entry version 162. DE RecName: Full=C-X-C motif chemokine 13; DE AltName: Full=Angie; DE AltName: Full=B cell-attracting chemokine 1; DE Short=BCA-1; DE AltName: Full=B lymphocyte chemoattractant; DE AltName: Full=CXC chemokine BLC; DE AltName: Full=Small-inducible cytokine B13; DE Flags: Precursor; GN Name=CXCL13; Synonyms=BCA1, BLC, SCYB13; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=9486651; DOI=10.1038/35876; RA Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., RA Williams L.T.; RT "A B-cell-homing chemokine made in lymphoid follicles activates RT Burkitt's lymphoma receptor-1."; RL Nature 391:799-803(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Peripheral blood leukocyte; RX PubMed=9463416; DOI=10.1084/jem.187.4.655; RA Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., RA Baggiolini M., Moser B.; RT "B cell-attracting chemokine 1, a human CXC chemokine expressed in RT lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."; RL J. Exp. Med. 187:655-660(1998). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Peripheral blood; RA Napolitano M., Spinetti G., Gaetano C., Capogrossi C.M.; RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skeletal muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Chemotactic for B-lymphocytes but not for T-lymphocytes, CC monocytes and neutrophils. Does not induce calcium release in B- CC lymphocytes. Binds to BLR1/CXCR5. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Highest levels in liver, followed by spleen, CC lymph node, appendix and stomach. Low levels in salivary gland, CC mammary gland and fetal spleen. CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) CC family. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Wikipedia; Note=CXCL13 entry; CC URL="https://en.wikipedia.org/wiki/CXCL13"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AF044197; AAC14402.1; -; mRNA. DR EMBL; AJ002211; CAA05250.1; -; mRNA. DR EMBL; AF029894; AAC17980.1; -; mRNA. DR EMBL; BC012589; AAH12589.1; -; mRNA. DR CCDS; CCDS3582.1; -. DR RefSeq; NP_006410.1; NM_006419.2. DR RefSeq; XP_006714126.1; XM_006714063.3. DR UniGene; Hs.100431; -. DR PDB; 4ZAI; X-ray; 1.95 A; A=23-109. DR PDB; 5CBA; X-ray; 2.50 A; E/F=23-109. DR PDB; 5CBE; X-ray; 2.40 A; E/F=23-109. DR PDBsum; 4ZAI; -. DR PDBsum; 5CBA; -. DR PDBsum; 5CBE; -. DR ProteinModelPortal; O43927; -. DR SMR; O43927; -. DR BioGrid; 115814; 4. DR DIP; DIP-5914N; -. DR IntAct; O43927; 9. DR MINT; O43927; -. DR STRING; 9606.ENSP00000286758; -. DR iPTMnet; O43927; -. DR PhosphoSitePlus; O43927; -. DR BioMuta; CXCL13; -. DR jPOST; O43927; -. DR PaxDb; O43927; -. DR PeptideAtlas; O43927; -. DR PRIDE; O43927; -. DR ProteomicsDB; 49240; -. DR DNASU; 10563; -. DR Ensembl; ENST00000286758; ENSP00000286758; ENSG00000156234. DR GeneID; 10563; -. DR KEGG; hsa:10563; -. DR CTD; 10563; -. DR DisGeNET; 10563; -. DR EuPathDB; HostDB:ENSG00000156234.7; -. DR GeneCards; CXCL13; -. DR HGNC; HGNC:10639; CXCL13. DR HPA; HPA052613; -. DR MIM; 605149; gene. DR neXtProt; NX_O43927; -. DR OpenTargets; ENSG00000156234; -. DR PharmGKB; PA35570; -. DR eggNOG; ENOG410JEN1; Eukaryota. DR eggNOG; ENOG4111E5H; LUCA. DR GeneTree; ENSGT00530000064292; -. DR HOGENOM; HOG000220915; -. DR HOVERGEN; HBG098474; -. DR InParanoid; O43927; -. DR KO; K10032; -. DR OMA; GCPNTEI; -. DR OrthoDB; 1510748at2759; -. DR PhylomeDB; O43927; -. DR TreeFam; TF335204; -. DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR ChiTaRS; CXCL13; human. DR GeneWiki; CXCL13; -. DR GenomeRNAi; 10563; -. DR PRO; PR:O43927; -. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000156234; Expressed in 139 organ(s), highest expression level in tonsil. DR ExpressionAtlas; O43927; baseline and differential. DR Genevisible; O43927; HS. DR GO; GO:0005623; C:cell; IEA:GOC. DR GO; GO:0005576; C:extracellular region; IDA:BHF-UCL. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0031735; F:CCR10 chemokine receptor binding; IDA:BHF-UCL. DR GO; GO:0008009; F:chemokine activity; IDA:BHF-UCL. DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; IPI:BHF-UCL. DR GO; GO:0031724; F:CXCR5 chemokine receptor binding; IDA:BHF-UCL. DR GO; GO:0017134; F:fibroblast growth factor binding; IDA:BHF-UCL. DR GO; GO:0008201; F:heparin binding; IDA:BHF-UCL. DR GO; GO:0046982; F:protein heterodimerization activity; IDA:BHF-UCL. DR GO; GO:0048018; F:receptor ligand activity; IDA:BHF-UCL. DR GO; GO:0090630; P:activation of GTPase activity; ISS:BHF-UCL. DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB. DR GO; GO:0035754; P:B cell chemotaxis; IDA:BHF-UCL. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:BHF-UCL. DR GO; GO:0007267; P:cell-cell signaling; IDA:BHF-UCL. DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0002544; P:chronic inflammatory response; NAS:BHF-UCL. DR GO; GO:0042742; P:defense response to bacterium; IDA:BHF-UCL. DR GO; GO:0035768; P:endothelial cell chemotaxis to fibroblast growth factor; IDA:BHF-UCL. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome. DR GO; GO:0002467; P:germinal center formation; NAS:BHF-UCL. DR GO; GO:0006955; P:immune response; IBA:GO_Central. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB. DR GO; GO:0030595; P:leukocyte chemotaxis; IBA:GO_Central. DR GO; GO:0002518; P:lymphocyte chemotaxis across high endothelial venule; ISS:BHF-UCL. DR GO; GO:2000545; P:negative regulation of endothelial cell chemotaxis to fibroblast growth factor; IDA:BHF-UCL. DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central. DR GO; GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; ISS:BHF-UCL. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:BHF-UCL. DR GO; GO:0033625; P:positive regulation of integrin activation; ISS:BHF-UCL. DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:BHF-UCL. DR GO; GO:0045765; P:regulation of angiogenesis; NAS:BHF-UCL. DR GO; GO:0002920; P:regulation of humoral immune response; NAS:BHF-UCL. DR CDD; cd00273; Chemokine_CXC; 1. DR InterPro; IPR001089; Chemokine_CXC. DR InterPro; IPR018048; Chemokine_CXC_CS. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR033899; CXC_Chemokine_domain. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR10179; PTHR10179; 1. DR Pfam; PF00048; IL8; 1. DR PRINTS; PR00437; SMALLCYTKCXC. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; SSF54117; 1. DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1. PE 1: Evidence at protein level; KW 3D-structure; Chemotaxis; Complete proteome; Cytokine; Disulfide bond; KW Inflammatory response; Reference proteome; Secreted; Signal. FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 109 C-X-C motif chemokine 13. FT /FTId=PRO_0000005113. FT DISULFID 33 60 {ECO:0000250}. FT DISULFID 35 76 {ECO:0000250}. FT STRAND 23 26 {ECO:0000244|PDB:4ZAI}. FT STRAND 35 37 {ECO:0000244|PDB:5CBE}. FT HELIX 45 47 {ECO:0000244|PDB:4ZAI}. FT STRAND 48 54 {ECO:0000244|PDB:4ZAI}. FT STRAND 60 62 {ECO:0000244|PDB:5CBE}. FT STRAND 64 69 {ECO:0000244|PDB:4ZAI}. FT STRAND 74 77 {ECO:0000244|PDB:4ZAI}. FT HELIX 82 93 {ECO:0000244|PDB:4ZAI}. SQ SEQUENCE 109 AA; 12664 MW; 4057FCA8EFF658A8 CRC64; MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR IQILPRGNGC PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP VPVFKRKIP //