ID   GON2_HUMAN              Reviewed;         120 AA.
AC   O43555; Q14C68; Q14C69; Q9BYN9; Q9BYP0;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   13-FEB-2019, entry version 142.
DE   RecName: Full=Progonadoliberin-2;
DE   AltName: Full=Progonadoliberin II;
DE   Contains:
DE     RecName: Full=Gonadoliberin-2;
DE     AltName: Full=Gonadoliberin II;
DE     AltName: Full=Gonadotropin-releasing hormone II;
DE              Short=GnRH II;
DE     AltName: Full=Luliberin II;
DE     AltName: Full=Luteinizing hormone-releasing hormone II;
DE              Short=LH-RH II;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 2;
DE     AltName: Full=GnRH-associated peptide II;
DE   Flags: Precursor;
GN   Name=GNRH2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX   PubMed=9419371; DOI=10.1073/pnas.95.1.305;
RA   White R.B., Eisen J.A., Kasten T.L., Fernald R.D.;
RT   "Second gene for gonadotropin-releasing hormone in humans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:305-309(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins; it stimulates
CC       the secretion of both luteinizing and follicle-stimulating
CC       hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Experimental confirmation may be lacking for some
CC         isoforms.;
CC       Name=1;
CC         IsoId=O43555-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O43555-2; Sequence=VSP_001825;
CC       Name=3;
CC         IsoId=O43555-3; Sequence=VSP_001826;
CC   -!- TISSUE SPECIFICITY: Midbrain; expressed at significantly higher
CC       levels outside the brain (up to 30-fold), particularly in the
CC       kidney, bone marrow and prostate.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; AF036329; AAC02980.1; -; Genomic_DNA.
DR   EMBL; AF036330; AAC02981.1; -; mRNA.
DR   EMBL; AL121905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471133; EAX10559.1; -; Genomic_DNA.
DR   EMBL; BC069362; AAH69362.1; -; mRNA.
DR   EMBL; BC115399; AAI15400.1; -; mRNA.
DR   EMBL; BC115400; AAI15401.1; -; mRNA.
DR   CCDS; CCDS13040.1; -. [O43555-1]
DR   CCDS; CCDS13041.1; -. [O43555-3]
DR   CCDS; CCDS13042.1; -. [O43555-2]
DR   RefSeq; NP_001297149.1; NM_001310220.1. [O43555-1]
DR   RefSeq; NP_001492.1; NM_001501.1. [O43555-1]
DR   RefSeq; NP_847901.1; NM_178331.1. [O43555-3]
DR   RefSeq; NP_847902.1; NM_178332.1. [O43555-2]
DR   RefSeq; XP_016883312.1; XM_017027823.1. [O43555-3]
DR   UniGene; Hs.129715; -.
DR   ProteinModelPortal; O43555; -.
DR   BioGrid; 109059; 1.
DR   STRING; 9606.ENSP00000245983; -.
DR   iPTMnet; O43555; -.
DR   PhosphoSitePlus; O43555; -.
DR   BioMuta; GNRH2; -.
DR   PaxDb; O43555; -.
DR   PeptideAtlas; O43555; -.
DR   PRIDE; O43555; -.
DR   ProteomicsDB; 49045; -.
DR   ProteomicsDB; 49046; -. [O43555-2]
DR   ProteomicsDB; 49047; -. [O43555-3]
DR   Ensembl; ENST00000245983; ENSP00000245983; ENSG00000125787. [O43555-1]
DR   Ensembl; ENST00000359100; ENSP00000352003; ENSG00000125787. [O43555-3]
DR   Ensembl; ENST00000380346; ENSP00000369704; ENSG00000125787. [O43555-2]
DR   Ensembl; ENST00000380347; ENSP00000369705; ENSG00000125787. [O43555-3]
DR   GeneID; 2797; -.
DR   KEGG; hsa:2797; -.
DR   UCSC; uc002whp.2; human. [O43555-1]
DR   CTD; 2797; -.
DR   DisGeNET; 2797; -.
DR   EuPathDB; HostDB:ENSG00000125787.11; -.
DR   GeneCards; GNRH2; -.
DR   HGNC; HGNC:4420; GNRH2.
DR   HPA; HPA004338; -.
DR   MIM; 602352; gene.
DR   neXtProt; NX_O43555; -.
DR   OpenTargets; ENSG00000125787; -.
DR   PharmGKB; PA28799; -.
DR   eggNOG; ENOG410J4MH; Eukaryota.
DR   eggNOG; ENOG4111DTA; LUCA.
DR   GeneTree; ENSGT00390000005119; -.
DR   HOGENOM; HOG000112757; -.
DR   HOVERGEN; HBG005044; -.
DR   InParanoid; O43555; -.
DR   KO; K05252; -.
DR   OMA; PSEAQHW; -.
DR   OrthoDB; 1325349at2759; -.
DR   PhylomeDB; O43555; -.
DR   TreeFam; TF353529; -.
DR   Reactome; R-HSA-375281; Hormone ligand-binding receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   GeneWiki; GNRH2; -.
DR   GenomeRNAi; 2797; -.
DR   PRO; PR:O43555; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000125787; Expressed in 81 organ(s), highest expression level in cerebellar hemisphere.
DR   Genevisible; O43555; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IBA:GO_Central.
DR   GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; TAS:ProtInc.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
DR   GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin_I.
DR   PANTHER; PTHR10522; PTHR10522; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Complete proteome; Hormone; Polymorphism; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    120       Progonadoliberin-2.
FT                                /FTId=PRO_0000012456.
FT   PEPTIDE      24     33       Gonadoliberin-2.
FT                                /FTId=PRO_0000012457.
FT   PEPTIDE      37    120       GnRH-associated peptide 2.
FT                                /FTId=PRO_0000012458.
FT   MOD_RES      33     33       Glycine amide. {ECO:0000250}.
FT   VAR_SEQ      52     59       Missing (in isoform 2). {ECO:0000305}.
FT                                /FTId=VSP_001825.
FT   VAR_SEQ      52     58       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_001826.
FT   VARIANT      16     16       A -> V (in dbSNP:rs6051545).
FT                                /FTId=VAR_053109.
SQ   SEQUENCE   120 AA;  12918 MW;  D58CDA14B6D6FB8D CRC64;
     MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGRALDTAAG
     SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA RTLLTAAREP RPAPPSSNKV
//