ID   O43469_HUMAN            Unreviewed;       382 AA.
AC   O43469; A0A1W2PRN0;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   13-FEB-2019, entry version 139.
DE   SubName: Full=KIR3DS1 {ECO:0000313|EMBL:AAV32445.1};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 2DL5A {ECO:0000313|Ensembl:ENSP00000491829};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 2DL5B {ECO:0000313|Ensembl:ENSP00000492575};
DE   SubName: Full=Killer cell immunoglobulin-like receptor 3DS1 {ECO:0000313|Ensembl:ENSP00000477819};
DE   SubName: Full=Killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 {ECO:0000313|EMBL:AAH98288.1};
DE   SubName: Full=Natural killer cell receptor KIR3DS1 variant {ECO:0000313|EMBL:AAB95317.1};
GN   Name=KIR2DL5B {ECO:0000313|Ensembl:ENSP00000492575};
GN   Synonyms=KIR2DL5A {ECO:0000313|Ensembl:ENSP00000491829},
GN   KIR3DS1 {ECO:0000313|EMBL:AAH98288.1,
GN   ECO:0000313|Ensembl:ENSP00000477819};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAB95317.1};
RN   [1] {ECO:0000313|EMBL:AAB95317.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9430220; DOI=10.1016/S1074-7613(00)80393-3;
RA   Valiante N.M., Uhrberg M., Shilling H.G., Lienert-Weidenbach K.,
RA   Arnett K.L., D'Andrea A., Phillips J.H., Lanier L.L., Parham P.;
RT   "Functionally and structurally distinct NK cell receptor repertoires
RT   in the peripheral blood of two human donors.";
RL   Immunity 7:739-751(1997).
RN   [2] {ECO:0000313|EMBL:AAB95317.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9430221; DOI=10.1016/S1074-7613(00)80394-5;
RA   Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G.,
RA   Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P.;
RT   "Human diversity in killer cell inhibitory receptor genes.";
RL   Immunity 7:753-763(1997).
RN   [3] {ECO:0000313|EMBL:AAB95317.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Shilling H.G.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAH98288.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5] {ECO:0000313|Ensembl:ENSP00000477819, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [6] {ECO:0000313|EMBL:AAV32445.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Norman P.J., Pando M., Yawata N., Yawata M., Tyan D., Parham P.;
RT   "Diversity of KIR3DL1. i. allele confirmation; genomic DNA from
RT   individuals other than original donor.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AAX89526.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17694054; DOI=10.1038/ng2111;
RA   Norman P.J., Abi-Rached L., Gendzekhadze K., Korbel D., Gleimer M.,
RA   Rowley D., Bruno D., Carrington C.V., Chandanayingyong D., Chang Y.H.,
RA   Crespi C., Saruhan-Direskeneli G., Fraser P.A., Hameed K.,
RA   Kamkamidze G., Koram K.A., Layrisse Z., Matamoros N., Mila J.,
RA   Park M.H., Pitchappan R.M., Ramdath D.D., Shiau M.Y., Stephens H.A.,
RA   Struik S., Verity D.H., Vaughan R.W., Tyan D., Davis R.W., Riley E.M.,
RA   Ronaghi M., Parham P.;
RT   "Unusual selection on the KIR3DL1/S1 natural killer cell receptor in
RT   Africans.";
RL   Nat. Genet. 39:1092-1099(2007).
RN   [8] {ECO:0000313|EMBL:ABX88986.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hou L., Hurley C.K., Steiner N.K., Belle I.;
RT   "Investigation of killer cell immunoglobulin-like receptor diversity
RT   in KIR3DL1 and KIR3DS1 in a transplant population.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AFV74754.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Pyo C.-W., Wang R., Vu Q.C., Geraghty D.E.;
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AFV74754.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23394822; DOI=10.1186/1471-2164-14-89;
RA   Pyo C.W., Wang R., Vu Q., Cereb N., Yang S.Y., Duh F.M., Wolinsky S.,
RA   Martin M.P., Carrington M., Geraghty D.E.;
RT   "Recombinant structures expand and contract inter and intragenic
RT   diversification at the KIR locus.";
RL   BMC Genomics 14:89-89(2013).
RN   [11] {ECO:0000313|Ensembl:ENSP00000477819}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [12] {ECO:0000313|Ensembl:ENSP00000491829}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2017) to UniProtKB.
RN   [13] {ECO:0000313|Ensembl:ENSP00000493624}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; AL133414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GU182359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KP420440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KU645196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KU645197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF022044; AAB95317.1; -; mRNA.
DR   EMBL; BC098288; AAH98288.1; -; mRNA.
DR   EMBL; AY760032; AAV32445.1; -; Genomic_DNA.
DR   EMBL; AY760055; AAX89526.1; -; Genomic_DNA.
DR   EMBL; AY760056; AAX89527.1; -; Genomic_DNA.
DR   EMBL; EU156175; ABX88986.1; -; Genomic_DNA.
DR   EMBL; JX008028; AFV74754.1; -; Genomic_DNA.
DR   RefSeq; NP_001077008.1; NM_001083539.2.
DR   UniGene; Hs.743496; -.
DR   Ensembl; ENST00000610716; ENSP00000482441; ENSG00000274283.
DR   Ensembl; ENST00000614429; ENSP00000480225; ENSG00000275608.
DR   Ensembl; ENST00000618890; ENSP00000477819; ENSG00000276534.
DR   Ensembl; ENST00000620498; ENSP00000482507; ENSG00000274465.
DR   Ensembl; ENST00000620926; ENSP00000484872; ENSG00000276498.
DR   Ensembl; ENST00000621178; ENSP00000478122; ENSG00000275037.
DR   Ensembl; ENST00000639016; ENSP00000491829; ENSG00000283889.
DR   Ensembl; ENST00000640177; ENSP00000492553; ENSG00000284111.
DR   Ensembl; ENST00000640772; ENSP00000492717; ENSG00000283719.
DR   Ensembl; ENST00000640919; ENSP00000492575; ENSG00000284301.
DR   Ensembl; ENST00000644102; ENSP00000494812; ENSG00000283889.
DR   Ensembl; ENST00000644389; ENSP00000493624; ENSG00000284301.
DR   Ensembl; ENST00000646860; ENSP00000496090; ENSG00000284111.
DR   Ensembl; ENST00000647019; ENSP00000494270; ENSG00000283719.
DR   GeneID; 3813; -.
DR   KEGG; hsa:3813; -.
DR   UCSC; uc032ltq.2; human.
DR   CTD; 3813; -.
DR   HGNC; HGNC:16345; KIR2DL5A.
DR   HGNC; HGNC:16346; KIR2DL5B.
DR   HGNC; HGNC:6340; KIR3DS1.
DR   PharmGKB; PA30125; -.
DR   eggNOG; ENOG410JAMM; Eukaryota.
DR   eggNOG; ENOG410ZT7K; LUCA.
DR   HOVERGEN; HBG074353; -.
DR   OrthoDB; 466470at2759; -.
DR   GenomeRNAi; 3813; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 3.
DR   SMART; SM00409; IG; 3.
DR   SUPFAM; SSF48726; SSF48726; 3.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AAB95317.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    382       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015096775.
FT   TRANSMEM    339    360       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    118       IG. {ECO:0000259|SMART:SM00409}.
FT   DOMAIN      129    209       IG. {ECO:0000259|SMART:SM00409}.
FT   DOMAIN      229    316       IG. {ECO:0000259|SMART:SM00409}.
SQ   SEQUENCE   382 AA;  42447 MW;  2153DECC96455417 CRC64;
     MLLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML
     YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPMVIMVTGN
     HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEWI SKDPSRLVGQ IHDGVSKANF
     SIGSMMRALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGL YEKPSLSAQP GPKVQAGESV
     TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
     PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI PFTILLFFLL
     HRWCSNKKKC CCNGPRACRE QK
//