ID LRRT2_HUMAN Reviewed; 516 AA. AC O43300; A0AVL3; A8K4U9; B7ZLN8; Q7L770; DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot. DT 19-JUL-2004, sequence version 3. DT 13-FEB-2019, entry version 145. DE RecName: Full=Leucine-rich repeat transmembrane neuronal protein 2; DE AltName: Full=Leucine-rich repeat neuronal 2 protein; DE Flags: Precursor; GN Name=LRRTM2; Synonyms=KIAA0416, LRRN2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=12676565; DOI=10.1016/S0888-7543(03)00030-2; RA Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.; RT "A novel gene family encoding leucine-rich repeat transmembrane RT proteins differentially expressed in the nervous system."; RL Genomics 81:411-421(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=9455477; DOI=10.1093/dnares/4.5.307; RA Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., RA Tanaka A., Kotani H., Nomura N., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. VIII. RT 78 new cDNA clones from brain which code for large proteins in RT vitro."; RL DNA Res. 4:307-313(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Involved in the development and maintenance of CC excitatory synapse in the vertebrate nervous system. Regulates CC surface expression of AMPA receptors and instructs the development CC of functional glutamate release sites. Acts as a ligand for the CC presynaptic receptors NRXN1-A and NRXN1-B (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with DLG4 and NRXN1. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane CC protein. Cell junction, synapse, postsynaptic cell membrane CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. CC Note=Localized to excitatory synapses. {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed in neuronal tissues. CC {ECO:0000269|PubMed:12676565}. CC -!- DOMAIN: Synaptogenic effects are mediated by the extracellular LRR CC region. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the LRRTM family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAA24846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AY182026; AAO67547.1; -; mRNA. DR EMBL; AB007876; BAA24846.2; ALT_INIT; mRNA. DR EMBL; AK291064; BAF83753.1; -; mRNA. DR EMBL; BC126408; AAI26409.1; -; mRNA. DR EMBL; BC126410; AAI26411.1; -; mRNA. DR EMBL; BC143926; AAI43927.1; -; mRNA. DR CCDS; CCDS47272.1; -. DR RefSeq; NP_056379.1; NM_015564.2. DR UniGene; Hs.656653; -. DR PDB; 5Z8X; X-ray; 3.15 A; A/B/C/D=34-373. DR PDB; 5Z8Y; X-ray; 3.40 A; A/C/E/G=34-371. DR PDBsum; 5Z8X; -. DR PDBsum; 5Z8Y; -. DR ProteinModelPortal; O43300; -. DR SMR; O43300; -. DR BioGrid; 117508; 12. DR IntAct; O43300; 1. DR STRING; 9606.ENSP00000274711; -. DR iPTMnet; O43300; -. DR PhosphoSitePlus; O43300; -. DR BioMuta; LRRTM2; -. DR PaxDb; O43300; -. DR PeptideAtlas; O43300; -. DR PRIDE; O43300; -. DR ProteomicsDB; 48875; -. DR DNASU; 26045; -. DR Ensembl; ENST00000274711; ENSP00000274711; ENSG00000146006. DR GeneID; 26045; -. DR KEGG; hsa:26045; -. DR UCSC; uc011cyz.2; human. DR CTD; 26045; -. DR DisGeNET; 26045; -. DR EuPathDB; HostDB:ENSG00000146006.7; -. DR GeneCards; LRRTM2; -. DR HGNC; HGNC:19409; LRRTM2. DR MIM; 610868; gene. DR neXtProt; NX_O43300; -. DR OpenTargets; ENSG00000146006; -. DR PharmGKB; PA134993038; -. DR eggNOG; KOG0619; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00940000160581; -. DR HOGENOM; HOG000290681; -. DR HOVERGEN; HBG052362; -. DR InParanoid; O43300; -. DR KO; K16665; -. DR OMA; AMATTYR; -. DR OrthoDB; 953344at2759; -. DR PhylomeDB; O43300; -. DR TreeFam; TF332659; -. DR Reactome; R-HSA-6794361; Neurexins and neuroligins. DR GenomeRNAi; 26045; -. DR PRO; PR:O43300; -. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000146006; Expressed in 138 organ(s), highest expression level in frontal cortex. DR ExpressionAtlas; O43300; baseline and differential. DR Genevisible; O43300; HS. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0060076; C:excitatory synapse; IEA:Ensembl. DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO. DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl. DR GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; IEA:Ensembl. DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl. DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IDA:SynGO. DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl. DR GO; GO:0042043; F:neurexin family protein binding; IEA:Ensembl. DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl. DR GO; GO:0002091; P:negative regulation of receptor internalization; IEA:Ensembl. DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl. DR GO; GO:0099151; P:regulation of postsynaptic density assembly; IEA:Ensembl. DR GO; GO:0050808; P:synapse organization; IEA:Ensembl. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR Pfam; PF13855; LRR_8; 3. DR SMART; SM00369; LRR_TYP; 9. DR PROSITE; PS51450; LRR; 10. PE 1: Evidence at protein level; KW 3D-structure; Cell junction; Cell membrane; Complete proteome; KW Glycoprotein; Leucine-rich repeat; Membrane; KW Postsynaptic cell membrane; Reference proteome; Repeat; Signal; KW Synapse; Transmembrane; Transmembrane helix. FT SIGNAL 1 33 {ECO:0000255}. FT CHAIN 34 516 Leucine-rich repeat transmembrane FT neuronal protein 2. FT /FTId=PRO_0000018353. FT TOPO_DOM 34 422 Extracellular. {ECO:0000255}. FT TRANSMEM 423 443 Helical. {ECO:0000255}. FT TOPO_DOM 444 516 Cytoplasmic. {ECO:0000255}. FT DOMAIN 34 61 LRRNT. FT REPEAT 63 83 LRR 1. FT REPEAT 86 107 LRR 2. FT REPEAT 110 131 LRR 3. FT REPEAT 134 155 LRR 4. FT REPEAT 158 179 LRR 5. FT REPEAT 182 203 LRR 6. FT REPEAT 206 227 LRR 7. FT REPEAT 230 251 LRR 8. FT REPEAT 254 275 LRR 9. FT REPEAT 278 299 LRR 10. FT DOMAIN 311 362 LRRCT. FT MOTIF 513 516 Involved in DLG4-binding. {ECO:0000250}. FT CARBOHYD 57 57 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 126 126 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 243 243 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 362 362 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CONFLICT 334 334 E -> G (in Ref. 3; BAF83753). FT {ECO:0000305}. FT STRAND 41 46 {ECO:0000244|PDB:5Z8X}. FT STRAND 64 67 {ECO:0000244|PDB:5Z8X}. FT TURN 78 81 {ECO:0000244|PDB:5Z8X}. FT STRAND 88 91 {ECO:0000244|PDB:5Z8X}. FT TURN 102 107 {ECO:0000244|PDB:5Z8X}. FT STRAND 113 115 {ECO:0000244|PDB:5Z8X}. FT TURN 126 131 {ECO:0000244|PDB:5Z8Y}. FT STRAND 137 139 {ECO:0000244|PDB:5Z8X}. FT TURN 150 155 {ECO:0000244|PDB:5Z8X}. FT STRAND 161 163 {ECO:0000244|PDB:5Z8X}. FT TURN 174 179 {ECO:0000244|PDB:5Z8X}. FT STRAND 185 187 {ECO:0000244|PDB:5Z8X}. FT TURN 198 203 {ECO:0000244|PDB:5Z8Y}. FT STRAND 209 211 {ECO:0000244|PDB:5Z8X}. FT STRAND 219 221 {ECO:0000244|PDB:5Z8X}. FT HELIX 222 225 {ECO:0000244|PDB:5Z8X}. FT STRAND 233 235 {ECO:0000244|PDB:5Z8X}. FT STRAND 243 245 {ECO:0000244|PDB:5Z8X}. FT STRAND 257 259 {ECO:0000244|PDB:5Z8X}. FT TURN 270 275 {ECO:0000244|PDB:5Z8X}. FT STRAND 281 283 {ECO:0000244|PDB:5Z8X}. FT HELIX 294 297 {ECO:0000244|PDB:5Z8X}. FT STRAND 304 307 {ECO:0000244|PDB:5Z8X}. FT HELIX 317 319 {ECO:0000244|PDB:5Z8X}. FT HELIX 320 328 {ECO:0000244|PDB:5Z8X}. FT STRAND 331 335 {ECO:0000244|PDB:5Z8Y}. FT TURN 343 347 {ECO:0000244|PDB:5Z8X}. FT HELIX 350 356 {ECO:0000244|PDB:5Z8X}. SQ SEQUENCE 516 AA; 59076 MW; F2EDD45C854BC3A6 CRC64; MGLHFKWPLG APMLAAIYAM SMVLKMLPAL GMACPPKCRC EKLLFYCDSQ GFHSVPNATD KGSLGLSLRH NHITELERDQ FASFSQLTWL HLDHNQISTV KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMEW TWGTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL RSLTTVGLSG NLWECSARIC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI LDAVHGFQLC WNLSTTVTVM ATTYRDPTTE YTKRISSSSY HVGDKEIPTT AGIAVTTEEH FPEPDNAIFT QRVITGTMAL LFSFFFIIFI VFISRKCCPP TLRRIRQCSM VQNHRQLRSQ TRLHMSNMSD QGPYNEYEPT HEGPFIIING YGQCKCQQLP YKECEV //