ID FGF10_HUMAN Reviewed; 208 AA. AC O15520; C7FDY0; Q6FHR3; Q6FHT6; Q96P59; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 13-FEB-2019, entry version 168. DE RecName: Full=Fibroblast growth factor 10; DE Short=FGF-10; DE AltName: Full=Keratinocyte growth factor 2; DE Flags: Precursor; GN Name=FGF10; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RX PubMed=9287324; DOI=10.1074/jbc.272.37.23191; RA Emoto H., Tagashira S., Mattei M.-G., Yamasaki M., Hashimoto G., RA Katsumata T., Negoro T., Nakatsuka M., Birnbaum D., Coulier F., RA Itoh N.; RT "Structure and expression of human fibroblast growth factor-10."; RL J. Biol. Chem. 272:23191-23194(1997). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RA Jimenez P.A., Gruber J.R., Liu B., Feng P., Florence C., Blunt A., RA Huddleston K.A., Teliska M., Alfonso P., Coleman T.A., Ornitz D.M., RA Dillon P.A., Duan R.D.; RT "Cutaneous wound healing by keratinocyte growth factor 2."; RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Nakhla A.M., Hryb D.J., Kahn S.M., Romas N.A., Rosner W.; RT "Expression of FGF10 in human prostate stromal cells."; RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RG NIEHS SNPs program; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP INTERACTION WITH FGFBP1. RX PubMed=15806171; DOI=10.1038/sj.onc.1208560; RA Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., RA Werner S.; RT "The fibroblast growth factor binding protein is a novel interaction RT partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: RT implications for epithelial repair."; RL Oncogene 24:5269-5277(2005). RN [10] RP INTERACTION WITH FGFR1 AND FGFR2, AND FUNCTION IN STIMULATION OF CELL RP PROLIFERATION. RX PubMed=16597617; DOI=10.1074/jbc.M601252200; RA Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., RA Ornitz D.M.; RT "Receptor specificity of the fibroblast growth factor family. The RT complete mammalian FGF family."; RL J. Biol. Chem. 281:15694-15700(2006). RN [11] RP REVIEW. RX PubMed=20094046; DOI=10.1038/nrc2780; RA Turner N., Grose R.; RT "Fibroblast growth factor signalling: from development to cancer."; RL Nat. Rev. Cancer 10:116-129(2010). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2. RX PubMed=12591959; DOI=10.1073/pnas.0436500100; RA Yeh B.K., Igarashi M., Eliseenkova A.V., Plotnikov A.N., Sher I., RA Ron D., Aaronson S.A., Mohammadi M.; RT "Structural basis by which alternative splicing confers specificity in RT fibroblast growth factor receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003). RN [13] RP INVOLVEMENT IN ALSG. RX PubMed=15654336; DOI=10.1038/ng1507; RA Entesarian M., Matsson H., Klar J., Bergendal B., Olson L., RA Arakaki R., Hayashi Y., Ohuchi H., Falahat B., Bolstad A.I., RA Jonsson R., Wahren-Herlenius M., Dahl N.; RT "Mutations in the gene encoding fibroblast growth factor 10 are RT associated with aplasia of lacrimal and salivary glands."; RL Nat. Genet. 37:125-127(2005). RN [14] RP VARIANT LADDS ARG-156. RX PubMed=16630169; DOI=10.1111/j.1399-0004.2006.00597.x; RA Milunsky J.M., Zhao G., Maher T.A., Colby R., Everman D.B.; RT "LADD syndrome is caused by FGF10 mutations."; RL Clin. Genet. 69:349-354(2006). RN [15] RP VARIANT LADDS PHE-106. RX PubMed=16501574; DOI=10.1038/ng1757; RA Rohmann E., Brunner H.G., Kayserili H., Uyguner O., Nuernberg G., RA Lew E.D., Dobbie A., Eswarakumar V.P., Uzumcu A., Ulubil-Emeroglu M., RA Leroy J.G., Li Y., Becker C., Lehnerdt K., Cremers C.W.R.J., RA Yueksel-Apak M., Nuernberg P., Kubisch C., Schlessinger J., RA van Bokhoven H., Wollnik B.; RT "Mutations in different components of FGF signaling in LADD RT syndrome."; RL Nat. Genet. 38:414-417(2006). CC -!- FUNCTION: Plays an important role in the regulation of embryonic CC development, cell proliferation and cell differentiation. Required CC for normal branching morphogenesis. May play a role in wound CC healing. {ECO:0000269|PubMed:16597617}. CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. CC {ECO:0000269|PubMed:12591959, ECO:0000269|PubMed:15806171, CC ECO:0000269|PubMed:16597617}. CC -!- INTERACTION: CC P21802:FGFR2; NbExp=2; IntAct=EBI-1035684, EBI-1028658; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- DISEASE: Aplasia of lacrimal and salivary glands (ALSG) CC [MIM:180920]: A rare condition characterized by dry conjunctival CC mucosae, irritable eyes, epiphora (constant tearing), and CC xerostomia (dryness of the mouth), which increases risk of dental CC erosion, dental caries, periodontal disease, and oral infections. CC ALSG has variable expressivity, and affected individuals may have CC aplasia or hypoplasia of the lacrimal, parotid, submandibular, and CC sublingual glands and absence of the lacrimal puncta. CC {ECO:0000269|PubMed:15654336}. Note=The disease is caused by CC mutations affecting the gene represented in this entry. CC -!- DISEASE: Lacrimo-auriculo-dento-digital syndrome (LADDS) CC [MIM:149730]: An autosomal dominant ectodermal dysplasia, a CC heterogeneous group of disorders due to abnormal development of CC two or more ectodermal structures. Lacrimo-auriculo-dento-digital CC syndrome is characterized by aplastic/hypoplastic lacrimal and CC salivary glands and ducts, cup-shaped ears, hearing loss, CC hypodontia and enamel hypoplasia, and distal limb segments CC anomalies. In addition to these cardinal features, facial CC dysmorphism, malformations of the kidney and respiratory system CC and abnormal genitalia have been reported. Craniosynostosis and CC severe syndactyly are not observed. {ECO:0000269|PubMed:16501574, CC ECO:0000269|PubMed:16630169}. Note=The disease is caused by CC mutations affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/fgf10/"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AB002097; BAA22331.1; -; mRNA. DR EMBL; U67918; AAB61991.1; -; mRNA. DR EMBL; AF411527; AAL05875.1; -; mRNA. DR EMBL; GQ351295; ACU00617.1; -; mRNA. DR EMBL; CR541665; CAG46466.1; -; mRNA. DR EMBL; CR541688; CAG46489.1; -; mRNA. DR EMBL; AY604046; AAS99733.1; -; Genomic_DNA. DR EMBL; CH471119; EAW56075.1; -; Genomic_DNA. DR EMBL; BC069561; AAH69561.1; -; mRNA. DR EMBL; BC105021; AAI05022.1; -; mRNA. DR EMBL; BC105023; AAI05024.1; -; mRNA. DR CCDS; CCDS3950.1; -. DR RefSeq; NP_004456.1; NM_004465.1. DR RefSeq; XP_005248321.1; XM_005248264.3. DR UniGene; Hs.248049; -. DR UniGene; Hs.664499; -. DR PDB; 1NUN; X-ray; 2.90 A; A=64-208. DR PDBsum; 1NUN; -. DR ProteinModelPortal; O15520; -. DR SMR; O15520; -. DR BioGrid; 108546; 8. DR DIP; DIP-6037N; -. DR IntAct; O15520; 5. DR STRING; 9606.ENSP00000264664; -. DR iPTMnet; O15520; -. DR PhosphoSitePlus; O15520; -. DR BioMuta; FGF10; -. DR EPD; O15520; -. DR jPOST; O15520; -. DR PaxDb; O15520; -. DR PeptideAtlas; O15520; -. DR PRIDE; O15520; -. DR ProteomicsDB; 48721; -. DR DNASU; 2255; -. DR Ensembl; ENST00000264664; ENSP00000264664; ENSG00000070193. DR GeneID; 2255; -. DR KEGG; hsa:2255; -. DR UCSC; uc003jog.2; human. DR CTD; 2255; -. DR DisGeNET; 2255; -. DR EuPathDB; HostDB:ENSG00000070193.4; -. DR GeneCards; FGF10; -. DR HGNC; HGNC:3666; FGF10. DR HPA; CAB010315; -. DR MalaCards; FGF10; -. DR MIM; 149730; phenotype. DR MIM; 180920; phenotype. DR MIM; 602115; gene. DR neXtProt; NX_O15520; -. DR OpenTargets; ENSG00000070193; -. DR Orphanet; 86815; Aplasia of lacrimal and salivary glands. DR Orphanet; 2363; Lacrimoauriculodentodigital syndrome. DR PharmGKB; PA28106; -. DR eggNOG; KOG3885; Eukaryota. DR eggNOG; ENOG4111IPH; LUCA. DR GeneTree; ENSGT00940000158907; -. DR HOGENOM; HOG000236341; -. DR HOVERGEN; HBG007580; -. DR InParanoid; O15520; -. DR KO; K04358; -. DR OMA; KENCPYX; -. DR OrthoDB; 1340221at2759; -. DR PhylomeDB; O15520; -. DR TreeFam; TF317805; -. DR Reactome; R-HSA-109704; PI3K Cascade. DR Reactome; R-HSA-1257604; PIP3 activates AKT signaling. DR Reactome; R-HSA-190370; FGFR1b ligand binding and activation. DR Reactome; R-HSA-190377; FGFR2b ligand binding and activation. DR Reactome; R-HSA-2033519; Activated point mutants of FGFR2. DR Reactome; R-HSA-210747; Regulation of gene expression in early pancreatic precursor cells. DR Reactome; R-HSA-2219530; Constitutive Signaling by Aberrant PI3K in Cancer. DR Reactome; R-HSA-5654219; Phospholipase C-mediated cascade: FGFR1. DR Reactome; R-HSA-5654221; Phospholipase C-mediated cascade, FGFR2. DR Reactome; R-HSA-5654687; Downstream signaling of activated FGFR1. DR Reactome; R-HSA-5654688; SHC-mediated cascade:FGFR1. DR Reactome; R-HSA-5654689; PI-3K cascade:FGFR1. DR Reactome; R-HSA-5654693; FRS-mediated FGFR1 signaling. DR Reactome; R-HSA-5654695; PI-3K cascade:FGFR2. DR Reactome; R-HSA-5654699; SHC-mediated cascade:FGFR2. DR Reactome; R-HSA-5654700; FRS-mediated FGFR2 signaling. DR Reactome; R-HSA-5654726; Negative regulation of FGFR1 signaling. DR Reactome; R-HSA-5654727; Negative regulation of FGFR2 signaling. DR Reactome; R-HSA-5655253; Signaling by FGFR2 in disease. DR Reactome; R-HSA-5658623; FGFRL1 modulation of FGFR1 signaling. DR Reactome; R-HSA-5673001; RAF/MAP kinase cascade. DR Reactome; R-HSA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. DR SignaLink; O15520; -. DR SIGNOR; O15520; -. DR EvolutionaryTrace; O15520; -. DR GeneWiki; FGF10; -. DR GenomeRNAi; 2255; -. DR PRO; PR:O15520; -. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000070193; Expressed in 119 organ(s), highest expression level in buccal mucosa cell. DR ExpressionAtlas; O15520; baseline and differential. DR Genevisible; O15520; HS. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; TAS:Reactome. DR GO; GO:0042056; F:chemoattractant activity; IDA:UniProtKB. DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IDA:UniProtKB. DR GO; GO:0008083; F:growth factor activity; IDA:UniProtKB. DR GO; GO:0008201; F:heparin binding; IDA:UniProtKB. DR GO; GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome. DR GO; GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome. DR GO; GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome. DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IPI:UniProtKB. DR GO; GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB. DR GO; GO:0000187; P:activation of MAPK activity; IDA:UniProtKB. DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl. DR GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl. DR GO; GO:0060667; P:branch elongation involved in salivary gland morphogenesis; IEA:Ensembl. DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IDA:UniProtKB. DR GO; GO:0060436; P:bronchiole morphogenesis; IEA:Ensembl. DR GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl. DR GO; GO:0060447; P:bud outgrowth involved in lung branching; IDA:MGI. DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl. DR GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl. DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl. DR GO; GO:0030538; P:embryonic genitalia morphogenesis; IEA:Ensembl. DR GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl. DR GO; GO:0010631; P:epithelial cell migration; IEA:Ensembl. DR GO; GO:0050673; P:epithelial cell proliferation; IDA:UniProtKB. DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IEA:Ensembl. DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IDA:UniProtKB. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl. DR GO; GO:0048807; P:female genitalia morphogenesis; IEA:Ensembl. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome. DR GO; GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; IDA:MGI. DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl. DR GO; GO:0070384; P:Harderian gland development; IEA:Ensembl. DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl. DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl. DR GO; GO:0032808; P:lacrimal gland development; IMP:UniProtKB. DR GO; GO:0060174; P:limb bud formation; IEA:Ensembl. DR GO; GO:0060428; P:lung epithelium development; IDA:MGI. DR GO; GO:0061115; P:lung proximal/distal axis specification; IEA:Ensembl. DR GO; GO:0060430; P:lung saccule development; IMP:UniProtKB. DR GO; GO:0048808; P:male genitalia morphogenesis; IEA:Ensembl. DR GO; GO:0060615; P:mammary gland bud formation; IEA:Ensembl. DR GO; GO:0000165; P:MAPK cascade; TAS:Reactome. DR GO; GO:0060915; P:mesenchymal cell differentiation involved in lung development; IEA:Ensembl. DR GO; GO:0060496; P:mesenchymal-epithelial cell signaling involved in lung development; IEA:Ensembl. DR GO; GO:0001823; P:mesonephros development; IEP:UniProtKB. DR GO; GO:0001656; P:metanephros development; IEP:UniProtKB. DR GO; GO:0003338; P:metanephros morphogenesis; IEA:Ensembl. DR GO; GO:0042693; P:muscle cell fate commitment; IEA:Ensembl. DR GO; GO:0071157; P:negative regulation of cell cycle arrest; IDA:UniProtKB. DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl. DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl. DR GO; GO:0001759; P:organ induction; IEA:Ensembl. DR GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl. DR GO; GO:0031016; P:pancreas development; IEA:Ensembl. DR GO; GO:0021983; P:pituitary gland development; IEA:Ensembl. DR GO; GO:0050918; P:positive chemotaxis; IDA:UniProtKB. DR GO; GO:0032781; P:positive regulation of ATPase activity; IDA:UniProtKB. DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0045739; P:positive regulation of DNA repair; IDA:UniProtKB. DR GO; GO:0045740; P:positive regulation of DNA replication; IMP:UniProtKB. DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IDA:UniProtKB. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:UniProtKB. DR GO; GO:0060054; P:positive regulation of epithelial cell proliferation involved in wound healing; NAS:UniProtKB. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB. DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl. DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB. DR GO; GO:0071338; P:positive regulation of hair follicle cell proliferation; IDA:UniProtKB. DR GO; GO:0051549; P:positive regulation of keratinocyte migration; IDA:UniProtKB. DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IDA:UniProtKB. DR GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IDA:UniProtKB. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB. DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; TAS:Reactome. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB. DR GO; GO:0050677; P:positive regulation of urothelial cell proliferation; IDA:UniProtKB. DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl. DR GO; GO:0070352; P:positive regulation of white fat cell proliferation; IEA:Ensembl. DR GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl. DR GO; GO:0034394; P:protein localization to cell surface; IDA:UniProtKB. DR GO; GO:0060019; P:radial glial cell differentiation; ISS:UniProtKB. DR GO; GO:0032925; P:regulation of activin receptor signaling pathway; IEA:Ensembl. DR GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Ensembl. DR GO; GO:0046877; P:regulation of saliva secretion; IMP:UniProtKB. DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl. DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0007431; P:salivary gland development; IMP:UniProtKB. DR GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; IDA:UniProtKB. DR GO; GO:0060879; P:semicircular canal fusion; IEA:Ensembl. DR GO; GO:0051145; P:smooth muscle cell differentiation; IEA:Ensembl. DR GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl. DR GO; GO:0048536; P:spleen development; IEA:Ensembl. DR GO; GO:0060661; P:submandibular salivary gland formation; IEA:Ensembl. DR GO; GO:0070075; P:tear secretion; IMP:UniProtKB. DR GO; GO:0048538; P:thymus development; IDA:UniProtKB. DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl. DR GO; GO:0042246; P:tissue regeneration; IEA:Ensembl. DR GO; GO:0060510; P:type II pneumocyte differentiation; IEA:Ensembl. DR GO; GO:0050674; P:urothelial cell proliferation; IDA:UniProtKB. DR GO; GO:0050872; P:white fat cell differentiation; IEA:Ensembl. DR GO; GO:0042060; P:wound healing; IDA:UniProtKB. DR CDD; cd00058; FGF; 1. DR InterPro; IPR028252; FGF10. DR InterPro; IPR002209; Fibroblast_GF_fam. DR InterPro; IPR008996; IL1/FGF. DR PANTHER; PTHR11486; PTHR11486; 1. DR PANTHER; PTHR11486:SF21; PTHR11486:SF21; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR SMART; SM00442; FGF; 1. DR SUPFAM; SSF50353; SSF50353; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disease mutation; KW Ectodermal dysplasia; Glycoprotein; Growth factor; KW Lacrimo-auriculo-dento-digital syndrome; Reference proteome; Secreted; KW Signal. FT SIGNAL 1 37 {ECO:0000255}. FT CHAIN 38 208 Fibroblast growth factor 10. FT /FTId=PRO_0000008981. FT COMPBIAS 52 62 Poly-Ser. FT CARBOHYD 51 51 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 196 196 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT VARIANT 106 106 C -> F (in LADDS; dbSNP:rs104893885). FT {ECO:0000269|PubMed:16501574}. FT /FTId=VAR_029888. FT VARIANT 156 156 I -> R (in LADDS; dbSNP:rs104893886). FT {ECO:0000269|PubMed:16630169}. FT /FTId=VAR_029889. FT CONFLICT 43 43 D -> V (in Ref. 5; CAG46489). FT {ECO:0000305}. FT CONFLICT 120 120 V -> A (in Ref. 3; AAL05875). FT {ECO:0000305}. FT CONFLICT 134 134 M -> R (in Ref. 3; AAL05875). FT {ECO:0000305}. FT HELIX 70 73 {ECO:0000244|PDB:1NUN}. FT STRAND 76 84 {ECO:0000244|PDB:1NUN}. FT STRAND 89 92 {ECO:0000244|PDB:1NUN}. FT STRAND 98 101 {ECO:0000244|PDB:1NUN}. FT STRAND 111 117 {ECO:0000244|PDB:1NUN}. FT STRAND 120 125 {ECO:0000244|PDB:1NUN}. FT TURN 126 129 {ECO:0000244|PDB:1NUN}. FT STRAND 130 134 {ECO:0000244|PDB:1NUN}. FT STRAND 138 145 {ECO:0000244|PDB:1NUN}. FT STRAND 150 156 {ECO:0000244|PDB:1NUN}. FT STRAND 162 171 {ECO:0000244|PDB:1NUN}. FT STRAND 174 177 {ECO:0000244|PDB:1NUN}. FT HELIX 189 191 {ECO:0000244|PDB:1NUN}. FT HELIX 197 199 {ECO:0000244|PDB:1NUN}. FT STRAND 201 205 {ECO:0000244|PDB:1NUN}. SQ SEQUENCE 208 AA; 23436 MW; C0A0705C108680B3 CRC64; MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL NGKGAPRRGQ KTRRKNTSAH FLPMVVHS //