ID   CCL16_HUMAN             Reviewed;         120 AA.
AC   O15467; Q4KKU0;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   13-FEB-2019, entry version 153.
DE   RecName: Full=C-C motif chemokine 16;
DE   AltName: Full=Chemokine CC-4;
DE            Short=HCC-4;
DE   AltName: Full=Chemokine LEC;
DE   AltName: Full=IL-10-inducible chemokine;
DE   AltName: Full=LCC-1;
DE   AltName: Full=Liver-expressed chemokine;
DE   AltName: Full=Lymphocyte and monocyte chemoattractant;
DE            Short=LMC;
DE   AltName: Full=Monotactin-1;
DE            Short=MTN-1;
DE   AltName: Full=NCC-4;
DE   AltName: Full=Small-inducible cytokine A16;
DE   Flags: Precursor;
GN   Name=CCL16; Synonyms=ILINCK, NCC4, SCYA16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC   TISSUE=Liver;
RX   PubMed=9596672;
RA   Hedrick J.A., Helms A., Vicari A., Zlotnik A.;
RT   "Characterization of a novel CC chemokine, HCC-4, whose expression is
RT   increased by interleukin-10.";
RL   Blood 91:4242-4247(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=9545580; DOI=10.1016/S0167-4781(97)00235-2;
RA   Shoudai K., Hieshima K., Fukuda S., Iio M., Miura R., Imai T.,
RA   Yoshie O., Nomiyama H.;
RT   "Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC.";
RL   Biochim. Biophys. Acta 1396:273-277(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10213461; DOI=10.1089/107999099314153;
RA   Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.;
RT   "Organization of the chemokine gene cluster on human chromosome
RT   17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and
RT   RANTES.";
RL   J. Interferon Cytokine Res. 19:227-234(1999).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9642106; DOI=10.1006/bbrc.1998.8762;
RA   Youn B.-S., Zhang S., Broxmeyer H.E., Antol K., Fraser M.J. Jr.,
RA   Hangoc G., Kwon B.S.;
RT   "Isolation and characterization of LMC, a novel lymphocyte and
RT   monocyte chemoattractant human CC chemokine, with myelosuppressive
RT   activity.";
RL   Biochem. Biophys. Res. Commun. 247:217-222(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=10235110; DOI=10.1089/104454999315330;
RA   Fukuda S., Hanano Y., Iio M., Miura R., Yoshie O., Nomiyama H.;
RT   "Genomic organization of the genes for human and mouse CC chemokine
RT   LEC.";
RL   DNA Cell Biol. 18:275-283(1999).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Liver;
RX   PubMed=10671294; DOI=10.1006/cyto.1999.0548;
RA   Yang J.-Y., Spanaus K.S., Widmer U.;
RT   "Cloning, characterization and genomic organization of LCC-1 (scya16),
RT   a novel human CC chemokine expressed in liver.";
RL   Cytokine 12:101-109(2000).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Shows chemotactic activity for lymphocytes and monocytes
CC       but not neutrophils. Also shows potent myelosuppressive activity,
CC       suppresses proliferation of myeloid progenitor cells. Recombinant
CC       SCYA16 shows chemotactic activity for monocytes and THP-1
CC       monocytes, but not for resting lymphocytes and neutrophils.
CC       Induces a calcium flux in THP-1 cells that were desensitized by
CC       prior expression to RANTES.
CC   -!- INTERACTION:
CC       P13501:CCL5; NbExp=2; IntAct=EBI-12204739, EBI-2848366;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in liver, also found in
CC       spleen and thymus. Highly expressed in LPS- and IFN-gamma-
CC       activated monocytes, weakly in some lymphocytes, including natural
CC       killer cells, gamma-delta T-cells, and some T-cell clones.
CC   -!- INDUCTION: By IL10/interleukin-10.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=CCL16 entry;
CC       URL="https://en.wikipedia.org/wiki/CCL16";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; U91746; AAC05587.1; -; mRNA.
DR   EMBL; AB007454; BAA24057.1; -; mRNA.
DR   EMBL; AF088219; AAC63330.1; -; Genomic_DNA.
DR   EMBL; AF055467; AAC28844.1; -; mRNA.
DR   EMBL; AB018249; BAA35138.1; -; Genomic_DNA.
DR   EMBL; AF039954; AAC97450.1; -; Genomic_DNA.
DR   EMBL; AF039955; AAC97451.1; -; mRNA.
DR   EMBL; BC099662; AAH99662.1; -; mRNA.
DR   CCDS; CCDS11303.1; -.
DR   PIR; JE0177; JE0177.
DR   RefSeq; NP_004581.1; NM_004590.3.
DR   RefSeq; XP_005258077.1; XM_005258020.4.
DR   UniGene; Hs.10458; -.
DR   PDB; 5LTL; X-ray; 1.45 A; A/B=24-120.
DR   PDBsum; 5LTL; -.
DR   ProteinModelPortal; O15467; -.
DR   SMR; O15467; -.
DR   DIP; DIP-5831N; -.
DR   IntAct; O15467; 2.
DR   STRING; 9606.ENSP00000293275; -.
DR   BioMuta; CCL16; -.
DR   PaxDb; O15467; -.
DR   PeptideAtlas; O15467; -.
DR   PRIDE; O15467; -.
DR   ProteomicsDB; 48683; -.
DR   TopDownProteomics; O15467; -.
DR   Ensembl; ENST00000611905; ENSP00000478024; ENSG00000275152.
DR   Ensembl; ENST00000621559; ENSP00000482168; ENSG00000275095.
DR   GeneID; 6360; -.
DR   KEGG; hsa:6360; -.
DR   UCSC; uc002hkl.4; human.
DR   CTD; 6360; -.
DR   DisGeNET; 6360; -.
DR   EuPathDB; HostDB:ENSG00000275152.4; -.
DR   GeneCards; CCL16; -.
DR   HGNC; HGNC:10614; CCL16.
DR   MIM; 601394; gene.
DR   neXtProt; NX_O15467; -.
DR   OpenTargets; ENSG00000275152; -.
DR   PharmGKB; PA35547; -.
DR   eggNOG; ENOG410J14J; Eukaryota.
DR   eggNOG; ENOG41119S1; LUCA.
DR   GeneTree; ENSGT00940000153494; -.
DR   HOGENOM; HOG000036685; -.
DR   InParanoid; O15467; -.
DR   KO; K21093; -.
DR   OMA; KKNREVC; -.
DR   OrthoDB; 1575018at2759; -.
DR   PhylomeDB; O15467; -.
DR   TreeFam; TF334888; -.
DR   Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   GenomeRNAi; 6360; -.
DR   PRO; PR:O15467; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000275152; Expressed in 71 organ(s), highest expression level in liver.
DR   ExpressionAtlas; O15467; baseline and differential.
DR   Genevisible; O15467; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IDA:UniProtKB.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0007154; P:cell communication; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chemotaxis; Complete proteome; Cytokine;
KW   Direct protein sequencing; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000269|PubMed:9596672}.
FT   CHAIN        24    120       C-C motif chemokine 16.
FT                                /FTId=PRO_0000005209.
FT   DISULFID     37     60       {ECO:0000250}.
FT   DISULFID     38     76       {ECO:0000250}.
FT   STRAND       35     37       {ECO:0000244|PDB:5LTL}.
FT   HELIX        48     50       {ECO:0000244|PDB:5LTL}.
FT   STRAND       51     57       {ECO:0000244|PDB:5LTL}.
FT   STRAND       59     62       {ECO:0000244|PDB:5LTL}.
FT   STRAND       64     69       {ECO:0000244|PDB:5LTL}.
FT   STRAND       74     77       {ECO:0000244|PDB:5LTL}.
FT   HELIX        82     89       {ECO:0000244|PDB:5LTL}.
SQ   SEQUENCE   120 AA;  13600 MW;  373D73016134D894 CRC64;
     MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL VVGYRKALNC
     HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN LSTVKIITAK NGQPQLLNSQ
//