ID   TMG2_HUMAN              Reviewed;         202 AA.
AC   O14669; Q6IBF8;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   13-FEB-2019, entry version 151.
DE   RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 2;
DE   AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 2;
DE            Short=Proline-rich Gla protein 2;
DE   Flags: Precursor;
GN   Name=PRRG2; Synonyms=PRGP2, TMG2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9256434; DOI=10.1073/pnas.94.17.9058;
RA   Kulman J.D., Harris J.E., Haldeman B.A., Davie E.W.;
RT   "Primary structure and tissue distribution of two novel proline-rich
RT   gamma-carboxyglutamic acid proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:9058-9062(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with NEDD4. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P46937:YAP1; NbExp=5; IntAct=EBI-9824765, EBI-1044059;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the thyroid.
CC   -!- PTM: Gla residues are produced after subsequent post-translational
CC       modifications of glutamate by a vitamin K-dependent gamma-
CC       carboxylase.
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DR   EMBL; AF009243; AAB67071.1; -; mRNA.
DR   EMBL; CR456846; CAG33127.1; -; mRNA.
DR   CCDS; CCDS12773.1; -.
DR   RefSeq; NP_000942.1; NM_000951.2.
DR   RefSeq; XP_006723349.1; XM_006723286.2.
DR   UniGene; Hs.35101; -.
DR   ProteinModelPortal; O14669; -.
DR   SMR; O14669; -.
DR   BioGrid; 111622; 4.
DR   DIP; DIP-60947N; -.
DR   IntAct; O14669; 2.
DR   MINT; O14669; -.
DR   STRING; 9606.ENSP00000246794; -.
DR   iPTMnet; O14669; -.
DR   PhosphoSitePlus; O14669; -.
DR   BioMuta; PRRG2; -.
DR   PaxDb; O14669; -.
DR   PeptideAtlas; O14669; -.
DR   PRIDE; O14669; -.
DR   ProteomicsDB; 48161; -.
DR   Ensembl; ENST00000246794; ENSP00000246794; ENSG00000126460.
DR   GeneID; 5639; -.
DR   KEGG; hsa:5639; -.
DR   UCSC; uc002pon.4; human.
DR   CTD; 5639; -.
DR   EuPathDB; HostDB:ENSG00000126460.10; -.
DR   GeneCards; PRRG2; -.
DR   HGNC; HGNC:9470; PRRG2.
DR   HPA; HPA010702; -.
DR   MIM; 604429; gene.
DR   neXtProt; NX_O14669; -.
DR   OpenTargets; ENSG00000126460; -.
DR   PharmGKB; PA33825; -.
DR   eggNOG; ENOG410J02V; Eukaryota.
DR   eggNOG; ENOG4111S2Z; LUCA.
DR   GeneTree; ENSGT00940000157077; -.
DR   HOGENOM; HOG000115997; -.
DR   HOVERGEN; HBG018454; -.
DR   InParanoid; O14669; -.
DR   OMA; SLGAFWY; -.
DR   OrthoDB; 1420559at2759; -.
DR   PhylomeDB; O14669; -.
DR   TreeFam; TF332123; -.
DR   ChiTaRS; PRRG2; human.
DR   GenomeRNAi; 5639; -.
DR   PRO; PR:O14669; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000126460; Expressed in 105 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; O14669; baseline and differential.
DR   Genevisible; O14669; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 4.10.740.10; -; 1.
DR   InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   Pfam; PF00594; Gla; 1.
DR   PRINTS; PR00001; GLABLOOD.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Disulfide bond; Membrane; Polymorphism;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   PROPEP       24     49
FT                                /FTId=PRO_0000022543.
FT   CHAIN        50    202       Transmembrane gamma-carboxyglutamic acid
FT                                protein 2.
FT                                /FTId=PRO_0000022544.
FT   TOPO_DOM     50    109       Extracellular. {ECO:0000255}.
FT   TRANSMEM    110    132       Helical. {ECO:0000255}.
FT   TOPO_DOM    133    202       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       50     96       Gla. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00463}.
FT   COMPBIAS    161    173       Poly-Pro.
FT   COMPBIAS    191    194       Poly-Pro.
FT   DISULFID     67     72       {ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   VARIANT      22     22       P -> S (in dbSNP:rs35016366).
FT                                /FTId=VAR_051442.
FT   VARIANT     116    116       G -> C (in dbSNP:rs2288920).
FT                                /FTId=VAR_020332.
SQ   SEQUENCE   202 AA;  22393 MW;  BC79400C98492060 CRC64;
     MRGHPSLLLL YMALTTCLDT SPSEETDQEV FLGPPEAQSF LSSHTRIPRA NHWDLELLTP
     GNLERECLEE RCSWEEAREY FEDNTLTERF WESYIYNGKG GRGRVDVASL AVGLTGGILL
     IVLAGLGAFW YLRWRQHRGQ QPCPQEAGLI SPLSPLNPLG PPTPLPPPPP PPPGLPTYEQ
     ALAASGVHDA PPPPYTSLRR PH
//