ID   CXL11_HUMAN             Reviewed;          94 AA.
AC   O14625; Q53YA3; Q92840;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   13-FEB-2019, entry version 177.
DE   RecName: Full=C-X-C motif chemokine 11;
DE   AltName: Full=Beta-R1;
DE   AltName: Full=H174;
DE   AltName: Full=Interferon gamma-inducible protein 9;
DE            Short=IP-9;
DE   AltName: Full=Interferon-inducible T-cell alpha chemoattractant;
DE            Short=I-TAC;
DE   AltName: Full=Small-inducible cytokine B11;
DE   Flags: Precursor;
GN   Name=CXCL11; Synonyms=ITAC, SCYB11, SCYB9B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Astrocyte;
RX   PubMed=8798467; DOI=10.1074/jbc.271.37.22878;
RA   Rani M.R.S., Foster G.R., Leung S., Leaman D., Stark G.R.,
RA   Ransohoff R.M.;
RT   "Characterization of beta-R1, a gene that is selectively induced by
RT   interferon beta (IFN-beta) compared with IFN-alpha.";
RL   J. Biol. Chem. 271:22878-22884(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Peripheral blood monocyte;
RX   PubMed=9370294; DOI=10.1016/S0378-1119(97)00330-2;
RA   Jacobs K.A., Collins-Racie L.A., Colbert M., Duckett M.,
RA   Golden-Fleet M., Kelleher K., Kriz R., LaVallie E.R., Merberg D.,
RA   Spaulding V., Stover J., Williamson M.J., McCoy J.M.;
RT   "A genetic selection for isolating cDNAs encoding secreted proteins.";
RL   Gene 198:289-296(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal astrocyte;
RX   PubMed=9625760; DOI=10.1084/jem.187.12.2009;
RA   Cole K.E., Strick C.A., Paradis T.J., Ogborne K.T., Loetscher M.,
RA   Gladue R.P., Lin W., Boyd J.G., Moser B., Wood D.E., Sahagan B.G.,
RA   Neote K.;
RT   "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel
RT   non-ELR CXC chemokine with potent activity on activated T cells
RT   through selective high affinity binding to CXCR3.";
RL   J. Exp. Med. 187:2009-2021(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-38, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Keratinocyte;
RX   PubMed=10233762; DOI=10.1046/j.1523-1747.1999.00581.x;
RA   Tensen C.P., Flier J., van der Raaij-Helmer E.M.H.,
RA   Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J.,
RA   Boorsma D.M., Willemze R.;
RT   "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand
RT   for the IP-10/Mig receptor (CXCR3).";
RL   J. Invest. Dermatol. 112:716-722(1999).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Myeloma;
RX   PubMed=10386863; DOI=10.1089/107999099313956;
RA   Laich A.M., Meyer M., Werner E.R., Werner-Felmayer G.;
RT   "Structure and expression of the human small cytokine B subfamily
RT   member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-
RT   gamma-treated human monocytes (THP-1).";
RL   J. Interferon Cytokine Res. 19:505-513(1999).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Keratinocyte;
RX   PubMed=10395932; DOI=10.1016/S0167-4781(99)00084-6;
RA   Tensen C.P., Flier J., Rampersad S., Sampat-Sardjoepersad S.,
RA   Scheper R.J., Boorsma D.M., Willemze R.;
RT   "Genomic organization, sequence and transcriptional regulation of the
RT   human CXCL 11 gene.";
RL   Biochim. Biophys. Acta 1446:167-172(1999).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow, Brain, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 28-84.
RX   PubMed=9730616;
RA   Erdel M., Laich A., Utermann G., Werner E.R., Werner-Felmayer G.;
RT   "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps
RT   to human chromosome 4q21 like the closely related genes for MIG
RT   (SCYB9) and INP10 (SCYB10).";
RL   Cytogenet. Cell Genet. 81:271-272(1998).
RN   [10]
RP   CITRULLINATION AT ARG-27.
RX   PubMed=18645041; DOI=10.1182/blood-2008-04-149039;
RA   Loos T., Mortier A., Gouwy M., Ronsse I., Put W., Lenaerts J.P.,
RA   Van Damme J., Proost P.;
RT   "Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a
RT   naturally occurring posttranslational modification of chemokines and
RT   new dimension of immunoregulation.";
RL   Blood 112:2648-2656(2008).
RN   [11]
RP   STRUCTURE BY NMR OF 22-94, AND DISULFIDE BONDS.
RX   PubMed=15273303; DOI=10.1110/ps.04791404;
RA   Booth V., Clark-Lewis I., Sykes B.D.;
RT   "NMR structure of CXCR3 binding chemokine CXCL11 (ITAC).";
RL   Protein Sci. 13:2022-2028(2004).
CC   -!- FUNCTION: Chemotactic for interleukin-activated T-cells but not
CC       unstimulated T-cells, neutrophils or monocytes. Induces calcium
CC       release in activated T-cells. Binds to CXCR3. May play an
CC       important role in CNS diseases which involve T-cell recruitment.
CC       May play a role in skin immune responses.
CC   -!- INTERACTION:
CC       Q99616:CCL13; NbExp=2; IntAct=EBI-2871971, EBI-725342;
CC       O00175:CCL24; NbExp=2; IntAct=EBI-2871971, EBI-16803966;
CC       Q9Y258:CCL26; NbExp=2; IntAct=EBI-2871971, EBI-7783416;
CC       P13501:CCL5; NbExp=2; IntAct=EBI-2871971, EBI-2848366;
CC       P48061:CXCL12; NbExp=3; IntAct=EBI-2871971, EBI-3913254;
CC       O95715:CXCL14; NbExp=2; IntAct=EBI-2871971, EBI-2798068;
CC       P27487:DPP4; NbExp=2; IntAct=EBI-2871971, EBI-2871277;
CC       Q5JR59:MTUS2; NbExp=3; IntAct=EBI-2871971, EBI-742948;
CC       P02776:PF4; NbExp=2; IntAct=EBI-2871971, EBI-2565740;
CC       P10720:PF4V1; NbExp=2; IntAct=EBI-2871971, EBI-1223944;
CC       P98066:TNFAIP6; NbExp=2; IntAct=EBI-11711364, EBI-11700693;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: High levels in peripheral blood leukocytes,
CC       pancreas and liver astrocytes. Moderate levels in thymus, spleen
CC       and lung. Low levels in placenta, prostate and small intestine.
CC       Also found in epidermal basal layer keratinocytes in skin
CC       disorders.
CC   -!- INDUCTION: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by
CC       IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts
CC       and endothelial cells, and by IL1/interleukin-1 in astrocytes.
CC   -!- MASS SPECTROMETRY: Mass=8303; Method=MALDI; Range=22-94;
CC       Evidence={ECO:0000269|PubMed:10233762};
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB17374.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=CXCL11 entry;
CC       URL="https://en.wikipedia.org/wiki/CXCL11";
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DR   EMBL; U59286; AAB17374.1; ALT_INIT; mRNA.
DR   EMBL; AF002985; AAC51845.1; -; mRNA.
DR   EMBL; AF030514; AAC39775.1; -; mRNA.
DR   EMBL; Y15220; CAA75510.1; -; mRNA.
DR   EMBL; U66096; AAD38867.1; -; mRNA.
DR   EMBL; AF077867; AAD38327.1; -; Genomic_DNA.
DR   EMBL; Y15221; CAB51859.1; -; Genomic_DNA.
DR   EMBL; BT006787; AAP35433.1; -; mRNA.
DR   EMBL; BC005292; AAH05292.1; -; mRNA.
DR   EMBL; BC012532; AAH12532.1; -; mRNA.
DR   EMBL; BC110986; AAI10987.1; -; mRNA.
DR   EMBL; AF053972; AAD10206.1; -; Genomic_DNA.
DR   CCDS; CCDS3574.1; -.
DR   RefSeq; NP_001289052.1; NM_001302123.1.
DR   RefSeq; NP_005400.1; NM_005409.4.
DR   UniGene; Hs.632592; -.
DR   PDB; 1RJT; NMR; -; A=22-94.
DR   PDBsum; 1RJT; -.
DR   ProteinModelPortal; O14625; -.
DR   SMR; O14625; -.
DR   BioGrid; 112275; 3.
DR   DIP; DIP-5890N; -.
DR   IntAct; O14625; 25.
DR   MINT; O14625; -.
DR   STRING; 9606.ENSP00000306884; -.
DR   iPTMnet; O14625; -.
DR   PhosphoSitePlus; O14625; -.
DR   BioMuta; CXCL11; -.
DR   PaxDb; O14625; -.
DR   PeptideAtlas; O14625; -.
DR   PRIDE; O14625; -.
DR   ProteomicsDB; 48123; -.
DR   DNASU; 6373; -.
DR   Ensembl; ENST00000306621; ENSP00000306884; ENSG00000169248.
DR   Ensembl; ENST00000503860; ENSP00000425819; ENSG00000169248.
DR   GeneID; 6373; -.
DR   KEGG; hsa:6373; -.
DR   UCSC; uc003hjm.4; human.
DR   CTD; 6373; -.
DR   DisGeNET; 6373; -.
DR   EuPathDB; HostDB:ENSG00000169248.12; -.
DR   GeneCards; CXCL11; -.
DR   HGNC; HGNC:10638; CXCL11.
DR   HPA; CAB009921; -.
DR   MIM; 604852; gene.
DR   neXtProt; NX_O14625; -.
DR   OpenTargets; ENSG00000169248; -.
DR   PharmGKB; PA35569; -.
DR   eggNOG; ENOG410JDG9; Eukaryota.
DR   eggNOG; ENOG41117T8; LUCA.
DR   GeneTree; ENSGT00530000064263; -.
DR   HOVERGEN; HBG107789; -.
DR   InParanoid; O14625; -.
DR   KO; K12672; -.
DR   OMA; GGRCLCI; -.
DR   OrthoDB; 1542450at2759; -.
DR   PhylomeDB; O14625; -.
DR   TreeFam; TF333433; -.
DR   Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   EvolutionaryTrace; O14625; -.
DR   GeneWiki; CXCL11; -.
DR   GenomeRNAi; 6373; -.
DR   PMAP-CutDB; O14625; -.
DR   PRO; PR:O14625; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000169248; Expressed in 101 organ(s), highest expression level in epithelium of bronchus.
DR   Genevisible; O14625; HS.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IDA:UniProtKB.
DR   GO; GO:0048248; F:CXCR3 chemokine receptor binding; IDA:UniProtKB.
DR   GO; GO:0008201; F:heparin binding; IMP:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IMP:UniProtKB.
DR   GO; GO:0006935; P:chemotaxis; IDA:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB.
DR   GO; GO:0030595; P:leukocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   GO; GO:0010818; P:T cell chemotaxis; IMP:UniProtKB.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR027221; CXCL11.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   PANTHER; PTHR10179:SF28; PTHR10179:SF28; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chemotaxis; Citrullination; Complete proteome; Cytokine;
KW   Direct protein sequencing; Disulfide bond; Inflammatory response;
KW   Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     21       {ECO:0000269|PubMed:10233762}.
FT   CHAIN        22     94       C-X-C motif chemokine 11.
FT                                /FTId=PRO_0000005106.
FT   MOD_RES      27     27       Citrulline; by PAD2.
FT                                {ECO:0000269|PubMed:18645041}.
FT   DISULFID     30     57       {ECO:0000269|PubMed:15273303}.
FT   DISULFID     32     74       {ECO:0000269|PubMed:15273303}.
FT   VARIANT      55     55       N -> S (in dbSNP:rs4859596).
FT                                /FTId=VAR_048700.
FT   CONFLICT     69     72       NKGQ -> IRK (in Ref. 1; AAB17374).
FT                                {ECO:0000305}.
FT   CONFLICT     78     78       K -> NRA (in Ref. 1; AAB17374).
FT                                {ECO:0000305}.
FT   CONFLICT     89     89       V -> A (in Ref. 1; AAB17374).
FT                                {ECO:0000305}.
FT   TURN         54     56       {ECO:0000244|PDB:1RJT}.
FT   STRAND       57     59       {ECO:0000244|PDB:1RJT}.
FT   STRAND       67     69       {ECO:0000244|PDB:1RJT}.
FT   HELIX        82     89       {ECO:0000244|PDB:1RJT}.
SQ   SEQUENCE   94 AA;  10365 MW;  9D9D8585749EA4CE CRC64;
     MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI
     EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
//