ID NET3_HUMAN Reviewed; 580 AA. AC O00634; DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 13-FEB-2019, entry version 151. DE RecName: Full=Netrin-3; DE AltName: Full=Netrin-2-like protein; DE Flags: Precursor; GN Name=NTN3; Synonyms=NTN2L; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8828041; DOI=10.1101/gr.6.6.525; RA Burn T.C., Connors T.D., Van Raay T.J., Dackowski W.R., RA Millholland J.M., Klinger K.W., Landes G.M.; RT "Generation of a transcriptional map for a 700-kb region surrounding RT the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis RT type 2 (TSC2) disease genes on human chromosome 16p3.3."; RL Genome Res. 6:525-537(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY. RX PubMed=9143507; DOI=10.1006/geno.1997.4659; RA Van Raay T.J., Foskett S.M., Connors T.D., Klinger K.W., Landes G.M., RA Burn T.C.; RT "The NTN2L gene encoding a novel human netrin maps to the autosomal RT dominant polycystic kidney disease region on chromosome 16p13.3."; RL Genomics 41:279-282(1997). CC -!- FUNCTION: Netrins control guidance of CNS commissural axons and CC peripheral motor axons. {ECO:0000250}. CC -!- INTERACTION: CC Q8NBI3:DRAXIN; NbExp=2; IntAct=EBI-10831998, EBI-10827752; CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Spinal cord. {ECO:0000269|PubMed:9143507}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U86759; AAC51247.1; -; mRNA. DR EMBL; U86758; AAC51246.1; -; Genomic_DNA. DR CCDS; CCDS10469.1; -. DR RefSeq; NP_006172.1; NM_006181.2. DR UniGene; Hs.158336; -. DR ProteinModelPortal; O00634; -. DR SMR; O00634; -. DR IntAct; O00634; 1. DR STRING; 9606.ENSP00000293973; -. DR GlyConnect; 1543; -. DR iPTMnet; O00634; -. DR PhosphoSitePlus; O00634; -. DR BioMuta; NTN3; -. DR PaxDb; O00634; -. DR PeptideAtlas; O00634; -. DR PRIDE; O00634; -. DR ProteomicsDB; 48004; -. DR Ensembl; ENST00000293973; ENSP00000293973; ENSG00000162068. DR GeneID; 4917; -. DR KEGG; hsa:4917; -. DR UCSC; uc002cqj.3; human. DR CTD; 4917; -. DR EuPathDB; HostDB:ENSG00000162068.1; -. DR GeneCards; NTN3; -. DR HGNC; HGNC:8030; NTN3. DR HPA; HPA050817; -. DR MIM; 602349; gene. DR neXtProt; NX_O00634; -. DR OpenTargets; ENSG00000162068; -. DR PharmGKB; PA164724231; -. DR eggNOG; KOG3512; Eukaryota. DR eggNOG; ENOG410XS7U; LUCA. DR GeneTree; ENSGT00940000153882; -. DR HOGENOM; HOG000286017; -. DR HOVERGEN; HBG006464; -. DR InParanoid; O00634; -. DR KO; K06844; -. DR OMA; CVKTPVP; -. DR OrthoDB; 858946at2759; -. DR PhylomeDB; O00634; -. DR TreeFam; TF352481; -. DR Reactome; R-HSA-375170; CDO in myogenesis. DR GenomeRNAi; 4917; -. DR PRO; PR:O00634; -. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000162068; Expressed in 28 organ(s), highest expression level in heart left ventricle. DR Genevisible; O00634; HS. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl. DR GO; GO:0007411; P:axon guidance; NAS:UniProtKB. DR Gene3D; 2.60.120.1490; -; 1. DR InterPro; IPR002049; Laminin_EGF. DR InterPro; IPR008211; Laminin_N. DR InterPro; IPR038684; Laminin_N_sf. DR InterPro; IPR001134; Netrin_domain. DR InterPro; IPR018933; Netrin_module_non-TIMP. DR InterPro; IPR008993; TIMP-like_OB-fold. DR Pfam; PF00053; Laminin_EGF; 3. DR Pfam; PF00055; Laminin_N; 1. DR Pfam; PF01759; NTR; 1. DR SMART; SM00643; C345C; 1. DR SMART; SM00180; EGF_Lam; 3. DR SMART; SM00136; LamNT; 1. DR SUPFAM; SSF50242; SSF50242; 1. DR PROSITE; PS00022; EGF_1; 2. DR PROSITE; PS01248; EGF_LAM_1; 3. DR PROSITE; PS50027; EGF_LAM_2; 3. DR PROSITE; PS51117; LAMININ_NTER; 1. DR PROSITE; PS50189; NTR; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; KW Laminin EGF-like domain; Polymorphism; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 27 {ECO:0000255}. FT CHAIN 28 580 Netrin-3. FT /FTId=PRO_0000017085. FT DOMAIN 36 254 Laminin N-terminal. {ECO:0000255|PROSITE- FT ProRule:PRU00466}. FT DOMAIN 255 308 Laminin EGF-like 1. {ECO:0000255|PROSITE- FT ProRule:PRU00460}. FT DOMAIN 311 371 Laminin EGF-like 2. {ECO:0000255|PROSITE- FT ProRule:PRU00460}. FT DOMAIN 374 421 Laminin EGF-like 3. {ECO:0000255|PROSITE- FT ProRule:PRU00460}. FT DOMAIN 441 577 NTR. {ECO:0000255|PROSITE- FT ProRule:PRU00295}. FT MOTIF 500 502 Cell attachment site; atypical. FT {ECO:0000255}. FT CARBOHYD 104 104 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 387 387 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 92 125 {ECO:0000250}. FT DISULFID 255 264 {ECO:0000250}. FT DISULFID 257 274 {ECO:0000250}. FT DISULFID 276 285 {ECO:0000250}. FT DISULFID 288 308 {ECO:0000250}. FT DISULFID 311 320 {ECO:0000250}. FT DISULFID 313 338 {ECO:0000250}. FT DISULFID 341 350 {ECO:0000250}. FT DISULFID 353 371 {ECO:0000250}. FT DISULFID 374 386 {ECO:0000250}. FT DISULFID 376 393 {ECO:0000250}. FT DISULFID 395 404 {ECO:0000250}. FT DISULFID 407 421 {ECO:0000250}. FT DISULFID 441 514 {ECO:0000250}. FT DISULFID 460 577 {ECO:0000250}. FT VARIANT 425 425 P -> S (in dbSNP:rs34818219). FT /FTId=VAR_050086. SQ SEQUENCE 580 AA; 61466 MW; 15F99643E74C644C CRC64; MPGWPWGLLL TAGTLFAALS PGPPAPADPC HDEGGAPRGC VPGLVNAALG REVLASSTCG RPATRACDAS DPRRAHSPAL LTSPGGTASP LCWRSESLPR APLNVTLTVP LGKAFELVFV SLRFCSAPPA SVALLKSQDH GRSWAPLGFF SSHCDLDYGR LPAPANGPAG PGPEALCFPA PLAQPDGSGL LAFSMQDSSP PGLDLDSSPV LQDWVTATDV RVVLTRPSTA GDPRDMEAVV PYSYAATDLQ VGGRCKCNGH ASRCLLDTQG HLICDCRHGT EGPDCGRCKP FYCDRPWQRA TARESHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC HYCREGFYRD PGRALSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT GLTCNRCAPG FQQSRSPVAP CVKTPIPGPT EDSSPVQPQD CDSHCKPARG SYRISLKKFC KKDYAVQVAV GARGEARGAW TRFPVAVLAV FRSGEERARR GSSALWVPAG DAACGCPRLL PGRRYLLLGG GPGAAAGGAG GRGPGLIAAR GSLVLPWRDA WTRRLRRLQR RERRGRCSAA //