ID CCL22_HUMAN Reviewed; 93 AA. AC O00626; A0N0Q6; B2R4W2; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 02-NOV-2010, sequence version 2. DT 13-FEB-2019, entry version 160. DE RecName: Full=C-C motif chemokine 22; DE AltName: Full=CC chemokine STCP-1; DE AltName: Full=MDC(1-69); DE AltName: Full=Macrophage-derived chemokine; DE AltName: Full=Small-inducible cytokine A22; DE AltName: Full=Stimulated T-cell chemotactic protein 1; DE Contains: DE RecName: Full=MDC(3-69); DE Contains: DE RecName: Full=MDC(5-69); DE Contains: DE RecName: Full=MDC(7-69); DE Flags: Precursor; GN Name=CCL22; Synonyms=MDC, SCYA22; ORFNames=A-152E5.1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-2. RC TISSUE=Macrophage; RX PubMed=9312138; DOI=10.1074/jbc.272.40.25229; RA Chang M.-S., McNinch J., Elias C. III, Manthey C.L., Grosshans D., RA Meng T., Boone T., Andrew D.P.; RT "Molecular cloning and functional characterization of a novel CC RT chemokine, stimulated T cell chemotactic protein (STCP-1) that RT specifically acts on activated T lymphocytes."; RL J. Biol. Chem. 272:25229-25237(1997). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35, AND VARIANT RP ALA-2. RC TISSUE=Macrophage; RX PubMed=9151897; DOI=10.1084/jem.185.9.1595; RA Godiska R., Chantry D., Raport C.J., Sozzani S., Allavena P., RA Leviten D., Mantovani A., Gray P.W.; RT "Human macrophage-derived chemokine (MDC), a novel chemoattractant for RT monocytes, monocyte-derived dendritic cells, and natural killer RT cells."; RL J. Exp. Med. 185:1595-1604(1997). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-2. RA Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., RA Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., RA Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., RA Nickerson D.A.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Peripheral blood; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-2. RX PubMed=10493829; DOI=10.1006/geno.1999.5927; RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., RA Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., RA Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., RA Harris P.C., Venter J.C., Adams M.D.; RT "Genome duplications and other features in 12 Mb of DNA sequence from RT human chromosome 16p and 16q."; RL Genomics 60:295-308(1999). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-2. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-2. RC TISSUE=Pancreas, and Spleen; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP RECEPTOR INTERACTION. RX PubMed=9430724; DOI=10.1074/jbc.273.3.1764; RA Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., RA Yoshie O., Gray P.W.; RT "Macrophage-derived chemokine is a functional ligand for the CC RT chemokine receptor 4."; RL J. Biol. Chem. 273:1764-1768(1998). RN [10] RP TISSUE SPECIFICITY, PROTEOLYTIC PROCESSING OF N-TERMINUS, AND RP IDENTIFICATION OF MDC(3-69); MDC(5-69) AND MDC(7-69). RC TISSUE=Dendritic cell; RX PubMed=11241286; RX DOI=10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L; RA Vulcano M., Albanesi C., Stoppacciaro A., Bagnati R., D'Amico G., RA Struyf S., Transidico P., Bonecchi R., Del Prete A., Allavena P., RA Ruco L.P., Chiabrando C., Girolomoni G., Mantovani A., Sozzani S.; RT "Dendritic cells as a major source of macrophage-derived RT chemokine/CCL22 in vitro and in vivo."; RL Eur. J. Immunol. 31:812-822(2001). CC -!- FUNCTION: May play a role in the trafficking of activated/effector CC T-lymphocytes to inflammatory sites and other aspects of activated CC T-lymphocyte physiology. Chemotactic for monocytes, dendritic CC cells and natural killer cells. Mild chemoattractant for primary CC activated T-lymphocytes and a potent chemoattractant for CC chronically activated T-lymphocytes but has no chemoattractant CC activity for neutrophils, eosinophils, and resting T-lymphocytes. CC Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) CC seem not be active. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Highly expressed in macrophage and in CC monocyte-derived dendritic cells, and thymus. Also found in lymph CC node, appendix, activated monocytes, resting and activated CC macrophages. Lower expression in lung and spleen. Very weak CC expression in small intestine. In lymph node expressed in a mature CC subset of Langerhans' cells (CD1a+ and CD83+). Expressed in CC Langerhans' cell histiocytosis but not in dermatopathic CC lymphadenopathy. Expressed in atopic dermatitis, allergic contact CC dermatitis skin, and psoriasis, in both the epidermis and dermis. CC {ECO:0000269|PubMed:11241286}. CC -!- PTM: The N-terminal processed forms MDC(3-69), MDC(5-69) and CC MDC(7-69) are produced by proteolytic cleavage after secretion CC from monocyte derived dendrocytes. {ECO:0000269|PubMed:11241286}. CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=Wikipedia; Note=CCL22 entry; CC URL="https://en.wikipedia.org/wiki/CCL22"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; U83239; AAB53372.1; -; mRNA. DR EMBL; U83171; AAB58360.1; -; mRNA. DR EMBL; EF064764; ABK41947.1; -; Genomic_DNA. DR EMBL; AK311970; BAG34909.1; -; mRNA. DR EMBL; AC004382; AAC24306.1; -; Genomic_DNA. DR EMBL; AC009052; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471092; EAW82918.1; -; Genomic_DNA. DR EMBL; BC027952; AAH27952.1; -; mRNA. DR CCDS; CCDS10778.1; -. DR RefSeq; NP_002981.2; NM_002990.4. DR RefSeq; XP_016879020.1; XM_017023531.1. DR UniGene; Hs.534347; -. DR ProteinModelPortal; O00626; -. DR SMR; O00626; -. DR BioGrid; 112270; 40. DR DIP; DIP-5849N; -. DR IntAct; O00626; 6. DR MINT; O00626; -. DR STRING; 9606.ENSP00000219235; -. DR iPTMnet; O00626; -. DR PhosphoSitePlus; O00626; -. DR BioMuta; CCL22; -. DR PaxDb; O00626; -. DR PeptideAtlas; O00626; -. DR PRIDE; O00626; -. DR ProteomicsDB; 48000; -. DR DNASU; 6367; -. DR Ensembl; ENST00000219235; ENSP00000219235; ENSG00000102962. DR GeneID; 6367; -. DR KEGG; hsa:6367; -. DR UCSC; uc002elh.4; human. DR CTD; 6367; -. DR DisGeNET; 6367; -. DR EuPathDB; HostDB:ENSG00000102962.4; -. DR GeneCards; CCL22; -. DR H-InvDB; HIX0013071; -. DR HGNC; HGNC:10621; CCL22. DR MIM; 602957; gene. DR neXtProt; NX_O00626; -. DR OpenTargets; ENSG00000102962; -. DR PharmGKB; PA35553; -. DR eggNOG; ENOG410J20K; Eukaryota. DR eggNOG; ENOG41113E8; LUCA. DR GeneTree; ENSGT00940000153084; -. DR HOGENOM; HOG000036685; -. DR HOVERGEN; HBG017871; -. DR InParanoid; O00626; -. DR KO; K21095; -. DR OMA; VEDSICC; -. DR OrthoDB; 1575018at2759; -. DR PhylomeDB; O00626; -. DR TreeFam; TF334888; -. DR Reactome; R-HSA-6783783; Interleukin-10 signaling. DR Reactome; R-HSA-6785807; Interleukin-4 and Interleukin-13 signaling. DR ChiTaRS; CCL22; human. DR GeneWiki; CCL22; -. DR GenomeRNAi; 6367; -. DR PRO; PR:O00626; -. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000102962; Expressed in 90 organ(s), highest expression level in heart right ventricle. DR Genevisible; O00626; HS. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central. DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central. DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central. DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0006935; P:chemotaxis; TAS:ProtInc. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome. DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0006955; P:immune response; TAS:ProtInc. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB. DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central. DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central. DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central. DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central. DR GO; GO:0009615; P:response to virus; TAS:ProtInc. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR InterPro; IPR030598; CCL22. DR InterPro; IPR039809; Chemokine_b/g/d. DR InterPro; IPR000827; Chemokine_CC_CS. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR12015; PTHR12015; 1. DR PANTHER; PTHR12015:SF102; PTHR12015:SF102; 1. DR Pfam; PF00048; IL8; 1. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; SSF54117; 1. DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1. PE 1: Evidence at protein level; KW Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing; KW Disulfide bond; Polymorphism; Reference proteome; Secreted; Signal. FT SIGNAL 1 24 {ECO:0000269|PubMed:9151897}. FT CHAIN 25 93 C-C motif chemokine 22. FT /FTId=PRO_0000005224. FT CHAIN 27 93 MDC(3-69). FT /FTId=PRO_0000005225. FT CHAIN 29 93 MDC(5-69). FT /FTId=PRO_0000005226. FT CHAIN 31 93 MDC(7-69). FT /FTId=PRO_0000005227. FT DISULFID 36 60 {ECO:0000250}. FT DISULFID 37 76 {ECO:0000250}. FT VARIANT 2 2 D -> A (in dbSNP:rs4359426). FT {ECO:0000269|PubMed:10493829, FT ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9151897, FT ECO:0000269|PubMed:9312138, FT ECO:0000269|Ref.3, ECO:0000269|Ref.7}. FT /FTId=VAR_055117. SQ SEQUENCE 93 AA; 10625 MW; 641FCE999586A7D2 CRC64; MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV KHFYWTSDSC PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ //