ID   UPK2_HUMAN              Reviewed;         184 AA.
AC   O00526; B0YJ92; O00457; Q53YV0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   13-FEB-2019, entry version 140.
DE   RecName: Full=Uroplakin-2;
DE            Short=UP2;
DE   AltName: Full=Uroplakin II;
DE            Short=UPII;
DE   Flags: Precursor;
GN   Name=UPK2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Ureter;
RX   PubMed=9846985; DOI=10.1016/S0002-9440(10)65709-4;
RA   Lobban E.D., Smith B.A., Hall G.D., Harnden P., Roberts P.,
RA   Selby P.J., Trejdosiewicz L.K., Southgate J.;
RT   "Uroplakin gene expression by normal and neoplastic human
RT   urothelium.";
RL   Am. J. Pathol. 153:1957-1967(1998).
RN   [2]
RP   SEQUENCE REVISION TO 163.
RA   Smith B.A.;
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=12792753;
RA   Hirata H., Hisatomi H., Kawakita M., Nagao K., Yamamoto S., Hikiji K.,
RA   Nakamoto T., Harasawa H., Kaneko N., Matsuda T., Yamamoto M.,
RA   Kanamaru T.;
RT   "Genetic detection for hematogenous micrometastasis in patients with
RT   various types of malignant tumors using Uroplakin II derived primers
RT   in polymerase chain reaction.";
RL   Oncol. Rep. 10:963-966(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Urinary bladder;
RA   Tong Q.S., Zheng L.D., Chen F.M., Zeng F.Q., Zhao J., Wang L.,
RA   Lu G.C.;
RT   "Cloning of human uroplakin II gene from Chinese transitional cell
RT   carcinoma of bladder patients.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   NHLBI resequencing and genotyping service (RS&G);
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 146-184.
RC   TISSUE=Urinary bladder carcinoma;
RA   Su S.L.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a
CC       highly specialized biomembrane elaborated by terminally
CC       differentiated urothelial cells. May play an important role in
CC       regulating the assembly of the AUM (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with uroplakin-1a (UPK1A). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N6L0:CCDC155; NbExp=3; IntAct=EBI-10179682, EBI-749265;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
CC       type I membrane protein {ECO:0000305}. Note=Heterodimer formation
CC       with UPK1A is a prerequisite to exit out of the endoplasmic
CC       reticulum (ER). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in ureter.
CC       {ECO:0000269|PubMed:9846985}.
CC   -!- SIMILARITY: Belongs to the uroplakin-2 family. {ECO:0000305}.
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DR   EMBL; Y13645; CAA73996.1; -; mRNA.
DR   EMBL; AB078607; BAB84089.1; -; Genomic_DNA.
DR   EMBL; AY455312; AAR19396.1; -; mRNA.
DR   EMBL; EF445028; ACA06070.1; -; Genomic_DNA.
DR   EMBL; BC113900; AAI13901.1; -; mRNA.
DR   EMBL; AF000562; AAB58416.1; -; mRNA.
DR   CCDS; CCDS8404.1; -.
DR   PIR; T09609; T09609.
DR   RefSeq; NP_006751.1; NM_006760.3.
DR   UniGene; Hs.379613; -.
DR   ProteinModelPortal; O00526; -.
DR   BioGrid; 113225; 42.
DR   IntAct; O00526; 28.
DR   STRING; 9606.ENSP00000264031; -.
DR   TCDB; 8.A.90.1.1; the uroplakin 2/3 (upk2/3) family.
DR   iPTMnet; O00526; -.
DR   PhosphoSitePlus; O00526; -.
DR   BioMuta; UPK2; -.
DR   MaxQB; O00526; -.
DR   PaxDb; O00526; -.
DR   PeptideAtlas; O00526; -.
DR   PRIDE; O00526; -.
DR   ProteomicsDB; 47956; -.
DR   TopDownProteomics; O00526; -.
DR   Ensembl; ENST00000264031; ENSP00000264031; ENSG00000110375.
DR   GeneID; 7379; -.
DR   KEGG; hsa:7379; -.
DR   UCSC; uc001puh.4; human.
DR   CTD; 7379; -.
DR   DisGeNET; 7379; -.
DR   EuPathDB; HostDB:ENSG00000110375.2; -.
DR   GeneCards; UPK2; -.
DR   HGNC; HGNC:12579; UPK2.
DR   HPA; HPA043312; -.
DR   HPA; HPA061106; -.
DR   MIM; 611558; gene.
DR   neXtProt; NX_O00526; -.
DR   OpenTargets; ENSG00000110375; -.
DR   PharmGKB; PA37211; -.
DR   eggNOG; ENOG410J8ZD; Eukaryota.
DR   eggNOG; ENOG4111EC7; LUCA.
DR   GeneTree; ENSGT00390000006115; -.
DR   HOGENOM; HOG000132917; -.
DR   HOVERGEN; HBG016837; -.
DR   InParanoid; O00526; -.
DR   OMA; PRRNMES; -.
DR   OrthoDB; 1415812at2759; -.
DR   PhylomeDB; O00526; -.
DR   TreeFam; TF337797; -.
DR   GeneWiki; UPK2; -.
DR   GenomeRNAi; 7379; -.
DR   PRO; PR:O00526; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110375; Expressed in 55 organ(s), highest expression level in urinary bladder.
DR   Genevisible; O00526; HS.
DR   GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0030855; P:epithelial cell differentiation; IDA:UniProtKB.
DR   GO; GO:0007275; P:multicellular organism development; TAS:ProtInc.
DR   CDD; cd09967; UP_II; 1.
DR   InterPro; IPR009952; Uroplakin-2.
DR   PANTHER; PTHR17573; PTHR17573; 1.
DR   Pfam; PF07353; Uroplakin_II; 1.
DR   PIRSF; PIRSF016439; Uroplakin_II; 1.
DR   ProDom; PD022112; Uroplakin_II; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cleavage on pair of basic residues; Complete proteome;
KW   Glycoprotein; Membrane; Polymorphism; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   PROPEP       26     84       {ECO:0000250}.
FT                                /FTId=PRO_0000022630.
FT   CHAIN        85    184       Uroplakin-2.
FT                                /FTId=PRO_0000022631.
FT   TOPO_DOM     85    155       Lumenal. {ECO:0000255}.
FT   TRANSMEM    156    176       Helical. {ECO:0000255}.
FT   TOPO_DOM    177    184       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     28     28       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     57     57       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     66     66       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VARIANT      47     47       A -> S (in dbSNP:rs3886020).
FT                                /FTId=VAR_051473.
FT   VARIANT     160    160       T -> M (in dbSNP:rs45530531).
FT                                /FTId=VAR_062246.
FT   CONFLICT    149    149       G -> A (in Ref. 7; AAB58416).
FT                                {ECO:0000305}.
SQ   SEQUENCE   184 AA;  19438 MW;  83D963F06050A585 CRC64;
     MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL
     MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL
     VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL
     GSRK
//