ID   M9MMK9_HUMAN            Unreviewed;       148 AA.
AC   M9MMK9;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   16-JAN-2019, entry version 37.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase C {ECO:0000313|Ensembl:ENSP00000356349};
DE   Flags: Fragment;
GN   Name=PTPRC {ECO:0000313|Ensembl:ENSP00000356349};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356349, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000356349, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000356349}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2013) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL157402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; M9MMK9; -.
DR   jPOST; M9MMK9; -.
DR   PeptideAtlas; M9MMK9; -.
DR   PRIDE; M9MMK9; -.
DR   Ensembl; ENST00000367379; ENSP00000356349; ENSG00000081237.
DR   UCSC; uc057oen.1; human.
DR   EuPathDB; HostDB:ENSG00000081237.18; -.
DR   HGNC; HGNC:9666; PTPRC.
DR   OpenTargets; ENSG00000081237; -.
DR   eggNOG; KOG4228; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000159457; -.
DR   ChiTaRS; PTPRC; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000081237; Expressed in 219 organ(s), highest expression level in blood.
DR   ExpressionAtlas; M9MMK9; baseline and differential.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR024739; PTP_recept_N.
DR   InterPro; IPR016335; Ptprc.
DR   Pfam; PF12567; CD45; 1.
DR   Pfam; PF12453; PTP_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:M9MMK9,
KW   ECO:0000213|PeptideAtlas:M9MMK9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    148       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004101124.
FT   DOMAIN        7     32       PTP_N. {ECO:0000259|Pfam:PF12453}.
FT   NON_TER     148    148       {ECO:0000313|Ensembl:ENSP00000356349}.
SQ   SEQUENCE   148 AA;  16119 MW;  2D5EF2A5100317B9 CRC64;
     MTMYLWLKLL AFGFAFLDTE VFVTGQSPTP SPTDAYLNAS ETTTLSPSGS AVISTTTIAT
     TPSKPTCDEK YANITVDYLY NKETKLFTAK LNVNENVECG NNTCTNNEVH NLTECKNASV
     SISHNSCTAP DKTLILDVPP GVEKFQLH
//