ID   SUPYN_HUMAN             Reviewed;         160 AA.
AC   M5A8F1;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 1.
DT   16-JAN-2019, entry version 19.
DE   RecName: Full=Suppressyn;
DE   AltName: Full=Endogenous retrovirus group 48 member 1;
DE   AltName: Full=NDUFV3 antisense RNA 1;
DE   AltName: Full=endogenous retrovirus group Fb member 1;
DE   Flags: Precursor;
GN   Name=ERVH48-1; Synonyms=C21orf105, HERV-Fb1, NDUFV3-AS1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SLC1A5,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Placenta;
RX   PubMed=23492904; DOI=10.1038/srep01462;
RA   Sugimoto J., Sugimoto M., Bernstein H., Jinno Y., Schust D.;
RT   "A novel human endogenous retroviral protein inhibits cell-cell
RT   fusion.";
RL   Sci. Rep. 3:1462-1462(2013).
CC   -!- FUNCTION: May play a role in trophoblasts syncytialization, the
CC       spontaneous fusion of their plasma membranes, an essential process
CC       in placental development. May negatively regulate cell-cell fusion
CC       by interacting with SLC1A5, the probable receptor on the cell
CC       surface of the fusogenic syncytin-1/ERVW-1.
CC       {ECO:0000269|PubMed:23492904}.
CC   -!- SUBUNIT: Interacts (secreted) with SLC1A5; mainly at cell surface.
CC       {ECO:0000269|PubMed:23492904}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23492904}.
CC       Note=Also found in cell lysates.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in placenta by
CC       extravillous trophoblasts and syncytiotrophoblasts (at protein
CC       level). {ECO:0000269|PubMed:23492904}.
CC   -!- MISCELLANEOUS: The human genome contains a high percentage of
CC       proviral-like elements, also called endogenous retroviruses (ERVs)
CC       that are the genomic traces of ancient infections of the germline
CC       by exogenous retroviruses. Although most of these elements are
CC       defective, some have conserved a functional envelope (env) gene,
CC       most probably diverted by the host for its benefit.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AB610407; BAN04646.1; -; mRNA.
DR   RefSeq; NP_001295420.1; NM_001308491.1.
DR   ProteinModelPortal; M5A8F1; -.
DR   BioMuta; HGNC:17216; -.
DR   EPD; M5A8F1; -.
DR   PRIDE; M5A8F1; -.
DR   GeneID; 90625; -.
DR   KEGG; hsa:90625; -.
DR   CTD; 90625; -.
DR   DisGeNET; 90625; -.
DR   GeneCards; ERVH48-1; -.
DR   HGNC; HGNC:17216; ERVH48-1.
DR   neXtProt; NX_M5A8F1; -.
DR   OrthoDB; 1320409at2759; -.
DR   GenomeRNAi; 90625; -.
DR   PRO; PR:M5A8F1; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0006949; P:syncytium formation; IMP:UniProtKB.
PE   1: Evidence at protein level;
KW   Complete proteome; ERV; Reference proteome; Secreted; Signal;
KW   Transposable element.
FT   SIGNAL        1     39       {ECO:0000255}.
FT   CHAIN        40    160       Suppressyn.
FT                                /FTId=PRO_0000430056.
SQ   SEQUENCE   160 AA;  18128 MW;  9D4F8B810EE9583A CRC64;
     MACIYPTTFY TSLPTKSLNM GISLTTILIL SVAVLLSTAA PPSCRECYQS LHYRGEMQQY
     FTYHTHIERS CYGNLIEECV ESGKSYYKVK NLGVCGSRNG AICPRGKQWL CFTKIGQWGV
     NTQVLEDIKR EQIIAKAKAS KPTTPPENRP RHFHSFIQKL
//